Pharmaceutical Science and Technology

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Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare

Received: 02 August 2019    Accepted: 21 August 2019    Published: 03 September 2019
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Abstract

This study was conducted to investigate the antiemetic, antimicrobial and anti-radical activity of methanolic extracts of Foeniculum vulgare. The antiemetic assay was carried out by using chick emetic model with minor modifications by calculating the mean decrease in the number of retching. The antimicrobial activity of the crude extract was performed by Disc Diffusion method. The anti-radical activity was determined by the 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) method. The anti-emetic activity of Foeniculum vulgare leaves on young chicks revealed that these extracts have a less anti-emetic effect. The group of chicks treated with Chlorpromazine was found to have 60.6 retches as compared to the 66 retches of the control group, thus Chlorpromazine reduced the retches by 7.93%. The chickens treated with leaves extracts inhibited the retches up to 2.03%. The minimum antimicrobial effect was found in this methanol crude extract. The extract did not appear potent in terms of both zones of inhibition and spectrum of activity. In anti-radical activity test, the extract showed moderate free radical scavenging activity with IC50 value 240.39μg/ml. while compared to that of the reference standard ascorbic acid. Methanolic extract of Foeniculum vulgare leaves have minimum anti-emetic and anti-microbial activities and moderate anti-radical properties.

DOI 10.11648/j.pst.20190301.14
Published in Pharmaceutical Science and Technology (Volume 3, Issue 1, June 2019)
Page(s) 27-33
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antiemetic, Antimicrobial, Antioxidant, Foeniculum vulgare

References
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Author Information
  • Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh

  • Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh; Department of Pharmacy, University of Asia Pacific, Dhaka, Bangladesh

  • Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh; Pratyasha Health Biomedical Research Center, Dhaka, Bangladesh

  • Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh

  • Department of Pharmaceutical Sciences, North South University, Dhaka, Bangladesh

  • Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh

  • Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh

  • Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh

  • Department of Applied Chemistry and Chemical Engineering, Noakhali Science and Technology University, Noakhali, Bangladesh

  • Department of Pharmacy, Atish Dipankar University of Science and Technology, Dhaka, Bangladesh

Cite This Article
  • APA Style

    Md. Ruhul Amin, Md. Abdullah-Al-Masum, Asma Kabir, Tofazzal Hossain Rubel, Md. Omar Faruqe, et al. (2019). Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare. Pharmaceutical Science and Technology, 3(1), 27-33. https://doi.org/10.11648/j.pst.20190301.14

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    ACS Style

    Md. Ruhul Amin; Md. Abdullah-Al-Masum; Asma Kabir; Tofazzal Hossain Rubel; Md. Omar Faruqe, et al. Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare. Pharm. Sci. Technol. 2019, 3(1), 27-33. doi: 10.11648/j.pst.20190301.14

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    AMA Style

    Md. Ruhul Amin, Md. Abdullah-Al-Masum, Asma Kabir, Tofazzal Hossain Rubel, Md. Omar Faruqe, et al. Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare. Pharm Sci Technol. 2019;3(1):27-33. doi: 10.11648/j.pst.20190301.14

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  • @article{10.11648/j.pst.20190301.14,
      author = {Md. Ruhul Amin and Md. Abdullah-Al-Masum and Asma Kabir and Tofazzal Hossain Rubel and Md. Omar Faruqe and Md. Shahadat Hossain and Md Abu Torab and Md. Afjal Hossain and Md. Shahadat Hossain and Shafayet Ahmed Siddiqui},
      title = {Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare},
      journal = {Pharmaceutical Science and Technology},
      volume = {3},
      number = {1},
      pages = {27-33},
      doi = {10.11648/j.pst.20190301.14},
      url = {https://doi.org/10.11648/j.pst.20190301.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.pst.20190301.14},
      abstract = {This study was conducted to investigate the antiemetic, antimicrobial and anti-radical activity of methanolic extracts of Foeniculum vulgare. The antiemetic assay was carried out by using chick emetic model with minor modifications by calculating the mean decrease in the number of retching. The antimicrobial activity of the crude extract was performed by Disc Diffusion method. The anti-radical activity was determined by the 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) method. The anti-emetic activity of Foeniculum vulgare leaves on young chicks revealed that these extracts have a less anti-emetic effect. The group of chicks treated with Chlorpromazine was found to have 60.6 retches as compared to the 66 retches of the control group, thus Chlorpromazine reduced the retches by 7.93%. The chickens treated with leaves extracts inhibited the retches up to 2.03%. The minimum antimicrobial effect was found in this methanol crude extract. The extract did not appear potent in terms of both zones of inhibition and spectrum of activity. In anti-radical activity test, the extract showed moderate free radical scavenging activity with IC50 value 240.39μg/ml. while compared to that of the reference standard ascorbic acid. Methanolic extract of Foeniculum vulgare leaves have minimum anti-emetic and anti-microbial activities and moderate anti-radical properties.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Pharmacological Study on a Potential Medicinal Herb-Foeniculum vulgare
    AU  - Md. Ruhul Amin
    AU  - Md. Abdullah-Al-Masum
    AU  - Asma Kabir
    AU  - Tofazzal Hossain Rubel
    AU  - Md. Omar Faruqe
    AU  - Md. Shahadat Hossain
    AU  - Md Abu Torab
    AU  - Md. Afjal Hossain
    AU  - Md. Shahadat Hossain
    AU  - Shafayet Ahmed Siddiqui
    Y1  - 2019/09/03
    PY  - 2019
    N1  - https://doi.org/10.11648/j.pst.20190301.14
    DO  - 10.11648/j.pst.20190301.14
    T2  - Pharmaceutical Science and Technology
    JF  - Pharmaceutical Science and Technology
    JO  - Pharmaceutical Science and Technology
    SP  - 27
    EP  - 33
    PB  - Science Publishing Group
    SN  - 2640-4540
    UR  - https://doi.org/10.11648/j.pst.20190301.14
    AB  - This study was conducted to investigate the antiemetic, antimicrobial and anti-radical activity of methanolic extracts of Foeniculum vulgare. The antiemetic assay was carried out by using chick emetic model with minor modifications by calculating the mean decrease in the number of retching. The antimicrobial activity of the crude extract was performed by Disc Diffusion method. The anti-radical activity was determined by the 2, 2-diphenyl-2-picrylhydrazyl hydrate (DPPH) method. The anti-emetic activity of Foeniculum vulgare leaves on young chicks revealed that these extracts have a less anti-emetic effect. The group of chicks treated with Chlorpromazine was found to have 60.6 retches as compared to the 66 retches of the control group, thus Chlorpromazine reduced the retches by 7.93%. The chickens treated with leaves extracts inhibited the retches up to 2.03%. The minimum antimicrobial effect was found in this methanol crude extract. The extract did not appear potent in terms of both zones of inhibition and spectrum of activity. In anti-radical activity test, the extract showed moderate free radical scavenging activity with IC50 value 240.39μg/ml. while compared to that of the reference standard ascorbic acid. Methanolic extract of Foeniculum vulgare leaves have minimum anti-emetic and anti-microbial activities and moderate anti-radical properties.
    VL  - 3
    IS  - 1
    ER  - 

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