The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate

Núñez Domínguez L. A.; Barrado Los Arcos L.; Saiz García H.; López Olmo N.; Arbeo Ruiz O.; García Nicolás M.

doi:doi:10.11648/j.ijdd.20170201.12

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The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate

Núñez Domínguez L. A., Barrado Los Arcos L., Saiz García H., López Olmo N., Arbeo Ruiz O., García Nicolás M.

Published in International Journal of Dual Diagnosis (Volume 2, Issue 1)

Received: 28 February 2017 Accepted: 4 March 2017 Published: 21 March 2017

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Abstract

The psychopharmacological treatment of psychotic dual disorders is a real challenge for the clinicians, due to the low level of adherence to the treatment in many cases. For this reason, in some recent guides (Cochrane, Nice) it had been proposed the use of Long-term antipsychotic treatment (LAI-APS) as a way to improve the adherence and increase the efficacy of the treatment. Paliperidone Palmitate is one the most recent LAI-APS, with very good results in the treatment of psychotic disorder, with low number of drop-outs due to the good tolerability to these effects. The authors carry-out a preliminary study comparing the tolerability and efficacy of this LAI-APS in two samples of schizophrenic patients, one of them with comorbid drug use. Our results shows that the treatment permits in both groups the decrease of dosage and/or number of concomitant oral antipsychotic treatment, decrease the number of psychiatric admissions and the use of drug, with no drop-out during a period of one years, comparing with the previous year. We conclude that Paliperidone Palmitate could be a useful treatment in the group of patients suffering psychotic disorder with comorbid drug use.

Published in	International Journal of Dual Diagnosis (Volume 2, Issue 1)
DOI	10.11648/j.ijdd.20170201.12
Page(s)	8-12
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Dual Disorders, Schizophrenia, Paliperidone Palmitate

References

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Núñez Domínguez L. A., Barrado Los Arcos L., Saiz García H., López Olmo N., Arbeo Ruiz O., et al. (2017). The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate. International Journal of Dual Diagnosis, 2(1), 8-12. https://doi.org/10.11648/j.ijdd.20170201.12

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ACS Style

Núñez Domínguez L. A.; Barrado Los Arcos L.; Saiz García H.; López Olmo N.; Arbeo Ruiz O., et al. The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate. Int. J. Dual Diagn. 2017, 2(1), 8-12. doi: 10.11648/j.ijdd.20170201.12

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AMA Style

Núñez Domínguez L. A., Barrado Los Arcos L., Saiz García H., López Olmo N., Arbeo Ruiz O., et al. The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate. Int J Dual Diagn. 2017;2(1):8-12. doi: 10.11648/j.ijdd.20170201.12

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@article{10.11648/j.ijdd.20170201.12,
  author = {Núñez Domínguez L. A. and Barrado Los Arcos L. and Saiz García H. and López Olmo N. and Arbeo Ruiz O. and García Nicolás M.},
  title = {The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate},
  journal = {International Journal of Dual Diagnosis},
  volume = {2},
  number = {1},
  pages = {8-12},
  doi = {10.11648/j.ijdd.20170201.12},
  url = {https://doi.org/10.11648/j.ijdd.20170201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijdd.20170201.12},
  abstract = {The psychopharmacological treatment of psychotic dual disorders is a real challenge for the clinicians, due to the low level of adherence to the treatment in many cases. For this reason, in some recent guides (Cochrane, Nice) it had been proposed the use of Long-term antipsychotic treatment (LAI-APS) as a way to improve the adherence and increase the efficacy of the treatment. Paliperidone Palmitate is one the most recent LAI-APS, with very good results in the treatment of psychotic disorder, with low number of drop-outs due to the good tolerability to these effects. The authors carry-out a preliminary study comparing the tolerability and efficacy of this LAI-APS in two samples of schizophrenic patients, one of them with comorbid drug use. Our results shows that the treatment permits in both groups the decrease of dosage and/or number of concomitant oral antipsychotic treatment, decrease the number of psychiatric admissions and the use of drug, with no drop-out during a period of one years, comparing with the previous year. We conclude that Paliperidone Palmitate could be a useful treatment in the group of patients suffering psychotic disorder with comorbid drug use.},
 year = {2017}
}

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TY - JOUR
T1 - The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate
AU - Núñez Domínguez L. A.
AU - Barrado Los Arcos L.
AU - Saiz García H.
AU - López Olmo N.
AU - Arbeo Ruiz O.
AU - García Nicolás M.
Y1 - 2017/03/21
PY - 2017
N1 - https://doi.org/10.11648/j.ijdd.20170201.12
DO - 10.11648/j.ijdd.20170201.12
T2 - International Journal of Dual Diagnosis
JF - International Journal of Dual Diagnosis
JO - International Journal of Dual Diagnosis
SP - 8
EP - 12
PB - Science Publishing Group
UR - https://doi.org/10.11648/j.ijdd.20170201.12
AB - The psychopharmacological treatment of psychotic dual disorders is a real challenge for the clinicians, due to the low level of adherence to the treatment in many cases. For this reason, in some recent guides (Cochrane, Nice) it had been proposed the use of Long-term antipsychotic treatment (LAI-APS) as a way to improve the adherence and increase the efficacy of the treatment. Paliperidone Palmitate is one the most recent LAI-APS, with very good results in the treatment of psychotic disorder, with low number of drop-outs due to the good tolerability to these effects. The authors carry-out a preliminary study comparing the tolerability and efficacy of this LAI-APS in two samples of schizophrenic patients, one of them with comorbid drug use. Our results shows that the treatment permits in both groups the decrease of dosage and/or number of concomitant oral antipsychotic treatment, decrease the number of psychiatric admissions and the use of drug, with no drop-out during a period of one years, comparing with the previous year. We conclude that Paliperidone Palmitate could be a useful treatment in the group of patients suffering psychotic disorder with comorbid drug use.
VL - 2
IS - 1
ER -

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Author Information

Núñez Domínguez L. A.
Barrado Los Arcos L.

Mental Health Net, Pamplona, Navarra, Spain
Saiz García H.

Mental Health Center, Pamplona, Navarra, Spain
López Olmo N.

Psychiatric Hospital, Vitoria, País Vasco, Spain
Arbeo Ruiz O.

Centro de Día Zuría, Pamplona, Navarra, Spain
García Nicolás M.

Mental Health Center, Tudela, Navarra, Spain

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Núñez Domínguez L. A., Barrado Los Arcos L., Saiz García H., López Olmo N., Arbeo Ruiz O., et al. (2017). The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate. International Journal of Dual Diagnosis, 2(1), 8-12. https://doi.org/10.11648/j.ijdd.20170201.12

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Núñez Domínguez L. A.; Barrado Los Arcos L.; Saiz García H.; López Olmo N.; Arbeo Ruiz O., et al. The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate. Int. J. Dual Diagn. 2017, 2(1), 8-12. doi: 10.11648/j.ijdd.20170201.12

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AMA Style

Núñez Domínguez L. A., Barrado Los Arcos L., Saiz García H., López Olmo N., Arbeo Ruiz O., et al. The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate. Int J Dual Diagn. 2017;2(1):8-12. doi: 10.11648/j.ijdd.20170201.12

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@article{10.11648/j.ijdd.20170201.12,
  author = {Núñez Domínguez L. A. and Barrado Los Arcos L. and Saiz García H. and López Olmo N. and Arbeo Ruiz O. and García Nicolás M.},
  title = {The Role of Long-Acting Antipsychotics in Patients Suffering a Schizophrenia and Comorbid Drug Use The Case of Paliperidone Palmitate},
  journal = {International Journal of Dual Diagnosis},
  volume = {2},
  number = {1},
  pages = {8-12},
  doi = {10.11648/j.ijdd.20170201.12},
  url = {https://doi.org/10.11648/j.ijdd.20170201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijdd.20170201.12},
  abstract = {The psychopharmacological treatment of psychotic dual disorders is a real challenge for the clinicians, due to the low level of adherence to the treatment in many cases. For this reason, in some recent guides (Cochrane, Nice) it had been proposed the use of Long-term antipsychotic treatment (LAI-APS) as a way to improve the adherence and increase the efficacy of the treatment. Paliperidone Palmitate is one the most recent LAI-APS, with very good results in the treatment of psychotic disorder, with low number of drop-outs due to the good tolerability to these effects. The authors carry-out a preliminary study comparing the tolerability and efficacy of this LAI-APS in two samples of schizophrenic patients, one of them with comorbid drug use. Our results shows that the treatment permits in both groups the decrease of dosage and/or number of concomitant oral antipsychotic treatment, decrease the number of psychiatric admissions and the use of drug, with no drop-out during a period of one years, comparing with the previous year. We conclude that Paliperidone Palmitate could be a useful treatment in the group of patients suffering psychotic disorder with comorbid drug use.},
 year = {2017}
}

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