Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3

Alice Branton; Snehasis Jana

doi:doi:10.11648/j.ajpp.20170201.12

| Peer-Reviewed

Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D₃ [25(OH)D₃] in Rats After a Single Oral Dose of Vitamin D₃

Alice Branton, Snehasis Jana

Published in American Journal of Pharmacology and Phytotherapy (Volume 2, Issue 1)

Received: 20 May 2017 Accepted: 12 June 2017 Published: 14 July 2017

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Abstract

There are numerous scientific studies on vitamin D₃ reported to have many important roles viz. in bone metabolism, osteoporosis, immunity, and useful in several diseases, e.g., cancers, cardio-vascular, and neurodegenerative diseases. Surprisingly, there is little information available about the concentration of 25-hydroxyvitamin D₃in the blood, which is the best indicator of vitamin D₃ status after its oral absorption. However, the biological activity of vit-D₃ is mediated via the formation of the active metabolite, 1-α, 25-dihydroxyvitamin D₃. There are several factors which affect its absorption and first-pass metabolism that lead to have very low plasma concentrations of both the metabolites (25-hydroxyvitamin D₃ and 1-α, 25-dihydroxyvitamin D₃) following an oral administration. Therefore, the present study was performed to determine the effects of The Trivedi Effect^®-Energy of Consciousness Healing Treatment on vit-D₃ and rats through the measurement of plasma 25-hydroxyvitamin D₃ concentrations after the oral administration of vit-D₃ in rats. The test item, vit-D₃ was divided into two parts. One part was denoted as the control (without Biofield Energy Healing Treatment), while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Alice Branton. Additionally, one group of animals also received Consciousness Energy Healing Treatment per se by the Healer under similar conditions. Vitamin D₃ oral formulations were administrated by oral gavage at a dose of 500 µg per kg in groups viz. G1 (untreated Vitamin D₃), G2 (Biofield Treated Vitamin D₃) and G3 (Biofield Treated animals received untreated Vitamin D₃) group. The Biofield Energy Healing Treatment significantly altered the relative oral exposure (AUC_0–t) of 25-hydroxyvitamin D₃ by 54.62% in G2 group compared to the control group, G1. The Biofield Energy Treatment also altered plasma peak concentration (C_max) of 25-hydroxyvitamin D₃ by 53.8% and 7.6% in G2 and G3 groups, respectively compared to the control group. After oral administration, plasma concentrations of 25-hydroxyvitamin D₃ in control group (G1) declined with slow excretion rate and the elimination half-life (T_1/2) was 100.59 hours. The oral elimination half-life (T_1/2) of 25-hydroxyvitamin D₃ in G2 and G3 were 69.09 hours and 55.76 hours, respectively. The mean residence time (MRT_last) and elimination rate constant (K_el) remained unaltered in all three groups. The Trivedi Effect^®-Energy of Consciousness Healing Treatment could be an innovative strategy which opens new avenues to overcome poorly absorbed pharmaceuticals/nutraceuticals/herbal extracts and can improve the therapeutic performance of orally active molecules.

Published in	American Journal of Pharmacology and Phytotherapy (Volume 2, Issue 1)
DOI	10.11648/j.ajpp.20170201.12
Page(s)	11-18
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2017. Published by Science Publishing Group

Keywords

Vitamin D, 25-hydroxyvitamin D₃, Ergocalciferol, Cholecalciferol, Biofield Energy Healing Treatment, Pharmacokinetics, Bioavailability, LC-MS/MS

References

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[36]	Trivedi MK, Nayak G, Patil S, Tallapragada RM, Jana S, Mishra R (2015) Bio-field treatment: An effective strategy to improve the quality of beef extract and meat infusion powder. J Nutr Food Sci 5: 389.
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[38]	Trivedi MK, Branton A, Trivedi D, Nayak G, Gangwar M, Jana S (2015) Effect of biofield energy treatment on chlorophyll content, pathological study, and molecular analysis of cashew plant (Anacardium occidentale L.). Journal of Plant Sciences 3: 372-382.
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Alice Branton, Snehasis Jana. (2017). Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3. American Journal of Pharmacology and Phytotherapy, 2(1), 11-18. https://doi.org/10.11648/j.ajpp.20170201.12

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ACS Style

Alice Branton; Snehasis Jana. Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3. Am. J. Pharmacol. Phytother. 2017, 2(1), 11-18. doi: 10.11648/j.ajpp.20170201.12

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AMA Style

Alice Branton, Snehasis Jana. Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3. Am J Pharmacol Phytother. 2017;2(1):11-18. doi: 10.11648/j.ajpp.20170201.12

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@article{10.11648/j.ajpp.20170201.12,
  author = {Alice Branton and Snehasis Jana},
  title = {Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3},
  journal = {American Journal of Pharmacology and Phytotherapy},
  volume = {2},
  number = {1},
  pages = {11-18},
  doi = {10.11648/j.ajpp.20170201.12},
  url = {https://doi.org/10.11648/j.ajpp.20170201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpp.20170201.12},
  abstract = {There are numerous scientific studies on vitamin D3 reported to have many important roles viz. in bone metabolism, osteoporosis, immunity, and useful in several diseases, e.g., cancers, cardio-vascular, and neurodegenerative diseases. Surprisingly, there is little information available about the concentration of 25-hydroxyvitamin D3 in the blood, which is the best indicator of vitamin D3 status after its oral absorption. However, the biological activity of vit-D3 is mediated via the formation of the active metabolite, 1-α, 25-dihydroxyvitamin D3. There are several factors which affect its absorption and first-pass metabolism that lead to have very low plasma concentrations of both the metabolites (25-hydroxyvitamin D3 and 1-α, 25-dihydroxyvitamin D3) following an oral administration. Therefore, the present study was performed to determine the effects of The Trivedi Effect®-Energy of Consciousness Healing Treatment on vit-D3 and rats through the measurement of plasma 25-hydroxyvitamin D3 concentrations after the oral administration of vit-D3 in rats. The test item, vit-D3 was divided into two parts. One part was denoted as the control (without Biofield Energy Healing Treatment), while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Alice Branton. Additionally, one group of animals also received Consciousness Energy Healing Treatment per se by the Healer under similar conditions. Vitamin D3 oral formulations were administrated by oral gavage at a dose of 500 µg per kg in groups viz. G1 (untreated Vitamin D3), G2 (Biofield Treated Vitamin D3) and G3 (Biofield Treated animals received untreated Vitamin D3) group. The Biofield Energy Healing Treatment significantly altered the relative oral exposure (AUC0–t) of 25-hydroxyvitamin D3 by 54.62% in G2 group compared to the control group, G1. The Biofield Energy Treatment also altered plasma peak concentration (Cmax) of 25-hydroxyvitamin D3 by 53.8% and 7.6% in G2 and G3 groups, respectively compared to the control group. After oral administration, plasma concentrations of 25-hydroxyvitamin D3 in control group (G1) declined with slow excretion rate and the elimination half-life (T1/2) was 100.59 hours. The oral elimination half-life (T1/2) of 25-hydroxyvitamin D3 in G2 and G3 were 69.09 hours and 55.76 hours, respectively. The mean residence time (MRTlast) and elimination rate constant (Kel) remained unaltered in all three groups. The Trivedi Effect®-Energy of Consciousness Healing Treatment could be an innovative strategy which opens new avenues to overcome poorly absorbed pharmaceuticals/nutraceuticals/herbal extracts and can improve the therapeutic performance of orally active molecules.},
 year = {2017}
}

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TY  - JOUR
T1  - Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3
AU  - Alice Branton
AU  - Snehasis Jana
Y1  - 2017/07/14
PY  - 2017
N1  - https://doi.org/10.11648/j.ajpp.20170201.12
DO  - 10.11648/j.ajpp.20170201.12
T2  - American Journal of Pharmacology and Phytotherapy
JF  - American Journal of Pharmacology and Phytotherapy
JO  - American Journal of Pharmacology and Phytotherapy
SP  - 11
EP  - 18
PB  - Science Publishing Group
UR  - https://doi.org/10.11648/j.ajpp.20170201.12
AB  - There are numerous scientific studies on vitamin D3 reported to have many important roles viz. in bone metabolism, osteoporosis, immunity, and useful in several diseases, e.g., cancers, cardio-vascular, and neurodegenerative diseases. Surprisingly, there is little information available about the concentration of 25-hydroxyvitamin D3 in the blood, which is the best indicator of vitamin D3 status after its oral absorption. However, the biological activity of vit-D3 is mediated via the formation of the active metabolite, 1-α, 25-dihydroxyvitamin D3. There are several factors which affect its absorption and first-pass metabolism that lead to have very low plasma concentrations of both the metabolites (25-hydroxyvitamin D3 and 1-α, 25-dihydroxyvitamin D3) following an oral administration. Therefore, the present study was performed to determine the effects of The Trivedi Effect®-Energy of Consciousness Healing Treatment on vit-D3 and rats through the measurement of plasma 25-hydroxyvitamin D3 concentrations after the oral administration of vit-D3 in rats. The test item, vit-D3 was divided into two parts. One part was denoted as the control (without Biofield Energy Healing Treatment), while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Alice Branton. Additionally, one group of animals also received Consciousness Energy Healing Treatment per se by the Healer under similar conditions. Vitamin D3 oral formulations were administrated by oral gavage at a dose of 500 µg per kg in groups viz. G1 (untreated Vitamin D3), G2 (Biofield Treated Vitamin D3) and G3 (Biofield Treated animals received untreated Vitamin D3) group. The Biofield Energy Healing Treatment significantly altered the relative oral exposure (AUC0–t) of 25-hydroxyvitamin D3 by 54.62% in G2 group compared to the control group, G1. The Biofield Energy Treatment also altered plasma peak concentration (Cmax) of 25-hydroxyvitamin D3 by 53.8% and 7.6% in G2 and G3 groups, respectively compared to the control group. After oral administration, plasma concentrations of 25-hydroxyvitamin D3 in control group (G1) declined with slow excretion rate and the elimination half-life (T1/2) was 100.59 hours. The oral elimination half-life (T1/2) of 25-hydroxyvitamin D3 in G2 and G3 were 69.09 hours and 55.76 hours, respectively. The mean residence time (MRTlast) and elimination rate constant (Kel) remained unaltered in all three groups. The Trivedi Effect®-Energy of Consciousness Healing Treatment could be an innovative strategy which opens new avenues to overcome poorly absorbed pharmaceuticals/nutraceuticals/herbal extracts and can improve the therapeutic performance of orally active molecules.
VL  - 2
IS  - 1
ER  -

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Author Information

Alice Branton

Trivedi Global, Inc., Henderson, Nevada, USA
Snehasis Jana

Trivedi Science Research Laboratory Pvt. Ltd., Bhopal, Madhya Pradesh, India

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Alice Branton, Snehasis Jana. (2017). Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3. American Journal of Pharmacology and Phytotherapy, 2(1), 11-18. https://doi.org/10.11648/j.ajpp.20170201.12

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ACS Style

Alice Branton; Snehasis Jana. Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3. Am. J. Pharmacol. Phytother. 2017, 2(1), 11-18. doi: 10.11648/j.ajpp.20170201.12

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AMA Style

Alice Branton, Snehasis Jana. Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3. Am J Pharmacol Phytother. 2017;2(1):11-18. doi: 10.11648/j.ajpp.20170201.12

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@article{10.11648/j.ajpp.20170201.12,
  author = {Alice Branton and Snehasis Jana},
  title = {Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3},
  journal = {American Journal of Pharmacology and Phytotherapy},
  volume = {2},
  number = {1},
  pages = {11-18},
  doi = {10.11648/j.ajpp.20170201.12},
  url = {https://doi.org/10.11648/j.ajpp.20170201.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajpp.20170201.12},
  abstract = {There are numerous scientific studies on vitamin D3 reported to have many important roles viz. in bone metabolism, osteoporosis, immunity, and useful in several diseases, e.g., cancers, cardio-vascular, and neurodegenerative diseases. Surprisingly, there is little information available about the concentration of 25-hydroxyvitamin D3 in the blood, which is the best indicator of vitamin D3 status after its oral absorption. However, the biological activity of vit-D3 is mediated via the formation of the active metabolite, 1-α, 25-dihydroxyvitamin D3. There are several factors which affect its absorption and first-pass metabolism that lead to have very low plasma concentrations of both the metabolites (25-hydroxyvitamin D3 and 1-α, 25-dihydroxyvitamin D3) following an oral administration. Therefore, the present study was performed to determine the effects of The Trivedi Effect®-Energy of Consciousness Healing Treatment on vit-D3 and rats through the measurement of plasma 25-hydroxyvitamin D3 concentrations after the oral administration of vit-D3 in rats. The test item, vit-D3 was divided into two parts. One part was denoted as the control (without Biofield Energy Healing Treatment), while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Alice Branton. Additionally, one group of animals also received Consciousness Energy Healing Treatment per se by the Healer under similar conditions. Vitamin D3 oral formulations were administrated by oral gavage at a dose of 500 µg per kg in groups viz. G1 (untreated Vitamin D3), G2 (Biofield Treated Vitamin D3) and G3 (Biofield Treated animals received untreated Vitamin D3) group. The Biofield Energy Healing Treatment significantly altered the relative oral exposure (AUC0–t) of 25-hydroxyvitamin D3 by 54.62% in G2 group compared to the control group, G1. The Biofield Energy Treatment also altered plasma peak concentration (Cmax) of 25-hydroxyvitamin D3 by 53.8% and 7.6% in G2 and G3 groups, respectively compared to the control group. After oral administration, plasma concentrations of 25-hydroxyvitamin D3 in control group (G1) declined with slow excretion rate and the elimination half-life (T1/2) was 100.59 hours. The oral elimination half-life (T1/2) of 25-hydroxyvitamin D3 in G2 and G3 were 69.09 hours and 55.76 hours, respectively. The mean residence time (MRTlast) and elimination rate constant (Kel) remained unaltered in all three groups. The Trivedi Effect®-Energy of Consciousness Healing Treatment could be an innovative strategy which opens new avenues to overcome poorly absorbed pharmaceuticals/nutraceuticals/herbal extracts and can improve the therapeutic performance of orally active molecules.},
 year = {2017}
}

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TY  - JOUR
T1  - Effect of The Biofield Energy Healing Treatment on the Pharmacokinetics of 25-Hydroxyvitamin D3 [25(OH)D3] in Rats After a Single Oral Dose of Vitamin D3
AU  - Alice Branton
AU  - Snehasis Jana
Y1  - 2017/07/14
PY  - 2017
N1  - https://doi.org/10.11648/j.ajpp.20170201.12
DO  - 10.11648/j.ajpp.20170201.12
T2  - American Journal of Pharmacology and Phytotherapy
JF  - American Journal of Pharmacology and Phytotherapy
JO  - American Journal of Pharmacology and Phytotherapy
SP  - 11
EP  - 18
PB  - Science Publishing Group
UR  - https://doi.org/10.11648/j.ajpp.20170201.12
AB  - There are numerous scientific studies on vitamin D3 reported to have many important roles viz. in bone metabolism, osteoporosis, immunity, and useful in several diseases, e.g., cancers, cardio-vascular, and neurodegenerative diseases. Surprisingly, there is little information available about the concentration of 25-hydroxyvitamin D3 in the blood, which is the best indicator of vitamin D3 status after its oral absorption. However, the biological activity of vit-D3 is mediated via the formation of the active metabolite, 1-α, 25-dihydroxyvitamin D3. There are several factors which affect its absorption and first-pass metabolism that lead to have very low plasma concentrations of both the metabolites (25-hydroxyvitamin D3 and 1-α, 25-dihydroxyvitamin D3) following an oral administration. Therefore, the present study was performed to determine the effects of The Trivedi Effect®-Energy of Consciousness Healing Treatment on vit-D3 and rats through the measurement of plasma 25-hydroxyvitamin D3 concentrations after the oral administration of vit-D3 in rats. The test item, vit-D3 was divided into two parts. One part was denoted as the control (without Biofield Energy Healing Treatment), while the other part was defined as the Biofield Energy Treated sample, which received the Biofield Energy Healing Treatment by renowned Biofield Energy Healer, Alice Branton. Additionally, one group of animals also received Consciousness Energy Healing Treatment per se by the Healer under similar conditions. Vitamin D3 oral formulations were administrated by oral gavage at a dose of 500 µg per kg in groups viz. G1 (untreated Vitamin D3), G2 (Biofield Treated Vitamin D3) and G3 (Biofield Treated animals received untreated Vitamin D3) group. The Biofield Energy Healing Treatment significantly altered the relative oral exposure (AUC0–t) of 25-hydroxyvitamin D3 by 54.62% in G2 group compared to the control group, G1. The Biofield Energy Treatment also altered plasma peak concentration (Cmax) of 25-hydroxyvitamin D3 by 53.8% and 7.6% in G2 and G3 groups, respectively compared to the control group. After oral administration, plasma concentrations of 25-hydroxyvitamin D3 in control group (G1) declined with slow excretion rate and the elimination half-life (T1/2) was 100.59 hours. The oral elimination half-life (T1/2) of 25-hydroxyvitamin D3 in G2 and G3 were 69.09 hours and 55.76 hours, respectively. The mean residence time (MRTlast) and elimination rate constant (Kel) remained unaltered in all three groups. The Trivedi Effect®-Energy of Consciousness Healing Treatment could be an innovative strategy which opens new avenues to overcome poorly absorbed pharmaceuticals/nutraceuticals/herbal extracts and can improve the therapeutic performance of orally active molecules.
VL  - 2
IS  - 1
ER  -

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