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Prediction of Upper Limits of Normal Values of Anti Streptolysin ‘O’ Titres in Normal Healthy School Going Children of 6–16 Years
American Journal of Pediatrics
Volume 5, Issue 2, June 2019, Pages: 74-77
Received: Feb. 27, 2019; Accepted: Apr. 11, 2019; Published: Jun. 20, 2019
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Chikkanarasa Reddy Parthihally Sanjeevaiah, Department of Paediatrics, Bengaluru Medical College and Research institute, Bengaluru, Republic of India
Mohammedmusthaq Ahamed, Department of Paediatrics, Bengaluru Medical College and Research institute, Bengaluru, Republic of India
Basavarajaiah Doddagangavadi Mariyappa, Department of Statistics and Computer Science, Diary Science College, KVAFSU(B), Bengaluru, Republic of India
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Antistreptolysin O test, an internationally gold standard test is widely used in detection of group A streptococcal infections and their sequelae at global level. An observational study was conducted at Bengaluru city during 2015-16. A total 454 children were randomly selected from the different schools in Bangalore city. As per the results, the sex ratio was 1:1(Male 230/454, Female 224/454) with mean age 12.58±2.63 years. The titre mean ASO value was 275.93±248.73 IU, median value was 202 IU. The average cut of ASO value was 256.53IU with good specificity (95.0%), sensitivity (88.05%), PPV (85.33%), NPV (68.93%); AUC was 0.93. The resulted findings was found to be statistically significant (P<0.01) and also this mean value will help for detection of streptococcal infections at population level (p<0.01). Majority of the cases were suffering from acute rheumatic fever (80%). Test algorithms was formulated by ROC analysis, the results showed that, the AUC of non-suppurative sequelae of Group-A streptococcal (GAS) infection of the throat (63.0%). The summing of the results concludes that, the ASO is a gold standard for the investigation of the disease progression at early stage (streptococcal and rheumatic fever). This present study will help to clinician’s for diagnose streptococcal infection at greater accuracy.
ASO, Children, ULN, streptococcal, ROC
To cite this article
Chikkanarasa Reddy Parthihally Sanjeevaiah, Mohammedmusthaq Ahamed, Basavarajaiah Doddagangavadi Mariyappa, Prediction of Upper Limits of Normal Values of Anti Streptolysin ‘O’ Titres in Normal Healthy School Going Children of 6–16 Years, American Journal of Pediatrics. Vol. 5, No. 2, 2019, pp. 74-77. doi: 10.11648/j.ajp.20190502.17
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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