Haptoglobin (Hp) is an acute phase protein. There exists three different Hp phenotypes that differ in their pro-inflammatory and anti-inflammatory action. Inflammation and oxidative stress are critically involved in many pathophysiological processes in childhood. We previously reported on the relationship of in-hospital clinical events and the Hp phenotype in a cohort of consecutive premature infants. This study provides follow up of childhood morbidity data and its relationship to the Hp phenotype for the previously reported study premature infant cohort. A phone questionnaire was carried out among the parents and medical history records were evaluated. The age of participants varied from eight to eleven years. The questionnaire included information about diseases with an inflammatory component in pathogenesis, infections and need for hospitalization. Of the original 122 study participants, morbidity data at eight to eleven years was available for 101 participants, and 100 were enrolled in the study. A less anti-inflammatory Hp phenotype (Hp 2-2) was more prevalent in participants who suffered from diseases with an inflammatory component in their pathogenesis (RTI, pneumonia, UTI, OM and tonsillitis) when these entities were analyzed as a group (p=0.043). Subsequent comparison of the cumulative number of episodes of these entities between Hp phenotypes during all follow up period detected a trend in the same direction. Further research involving a larger population is required for better understanding of the Hp phenotype role in infantile and pediatric morbidity.
| Published in | American Journal of Pediatrics (Volume 6, Issue 1) |
| DOI | 10.11648/j.ajp.20200601.23 |
| Page(s) | 73-77 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Childhood Morbidity, Haptoglobin Phenotype, Infection, Inflammation
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APA Style
Irena Kessel, Michal Molad, Rada Nemirovsky, Keren Lavie-Nevo, Andrew Peter Levy, et al. (2020). Haptoglobin Polymorphism and Morbidity in Children Born Prematurely. American Journal of Pediatrics, 6(1), 73-77. https://doi.org/10.11648/j.ajp.20200601.23
ACS Style
Irena Kessel; Michal Molad; Rada Nemirovsky; Keren Lavie-Nevo; Andrew Peter Levy, et al. Haptoglobin Polymorphism and Morbidity in Children Born Prematurely. Am. J. Pediatr. 2020, 6(1), 73-77. doi: 10.11648/j.ajp.20200601.23
AMA Style
Irena Kessel, Michal Molad, Rada Nemirovsky, Keren Lavie-Nevo, Andrew Peter Levy, et al. Haptoglobin Polymorphism and Morbidity in Children Born Prematurely. Am J Pediatr. 2020;6(1):73-77. doi: 10.11648/j.ajp.20200601.23
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Download@article{10.11648/j.ajp.20200601.23,
author = {Irena Kessel and Michal Molad and Rada Nemirovsky and Keren Lavie-Nevo and Andrew Peter Levy and Shany Blum and Avi Rotschild},
title = {Haptoglobin Polymorphism and Morbidity in Children Born Prematurely},
journal = {American Journal of Pediatrics},
volume = {6},
number = {1},
pages = {73-77},
doi = {10.11648/j.ajp.20200601.23},
url = {https://doi.org/10.11648/j.ajp.20200601.23},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20200601.23},
abstract = {Haptoglobin (Hp) is an acute phase protein. There exists three different Hp phenotypes that differ in their pro-inflammatory and anti-inflammatory action. Inflammation and oxidative stress are critically involved in many pathophysiological processes in childhood. We previously reported on the relationship of in-hospital clinical events and the Hp phenotype in a cohort of consecutive premature infants. This study provides follow up of childhood morbidity data and its relationship to the Hp phenotype for the previously reported study premature infant cohort. A phone questionnaire was carried out among the parents and medical history records were evaluated. The age of participants varied from eight to eleven years. The questionnaire included information about diseases with an inflammatory component in pathogenesis, infections and need for hospitalization. Of the original 122 study participants, morbidity data at eight to eleven years was available for 101 participants, and 100 were enrolled in the study. A less anti-inflammatory Hp phenotype (Hp 2-2) was more prevalent in participants who suffered from diseases with an inflammatory component in their pathogenesis (RTI, pneumonia, UTI, OM and tonsillitis) when these entities were analyzed as a group (p=0.043). Subsequent comparison of the cumulative number of episodes of these entities between Hp phenotypes during all follow up period detected a trend in the same direction. Further research involving a larger population is required for better understanding of the Hp phenotype role in infantile and pediatric morbidity.},
year = {2020}
}
TY - JOUR T1 - Haptoglobin Polymorphism and Morbidity in Children Born Prematurely AU - Irena Kessel AU - Michal Molad AU - Rada Nemirovsky AU - Keren Lavie-Nevo AU - Andrew Peter Levy AU - Shany Blum AU - Avi Rotschild Y1 - 2020/02/28 PY - 2020 N1 - https://doi.org/10.11648/j.ajp.20200601.23 DO - 10.11648/j.ajp.20200601.23 T2 - American Journal of Pediatrics JF - American Journal of Pediatrics JO - American Journal of Pediatrics SP - 73 EP - 77 PB - Science Publishing Group SN - 2472-0909 UR - https://doi.org/10.11648/j.ajp.20200601.23 AB - Haptoglobin (Hp) is an acute phase protein. There exists three different Hp phenotypes that differ in their pro-inflammatory and anti-inflammatory action. Inflammation and oxidative stress are critically involved in many pathophysiological processes in childhood. We previously reported on the relationship of in-hospital clinical events and the Hp phenotype in a cohort of consecutive premature infants. This study provides follow up of childhood morbidity data and its relationship to the Hp phenotype for the previously reported study premature infant cohort. A phone questionnaire was carried out among the parents and medical history records were evaluated. The age of participants varied from eight to eleven years. The questionnaire included information about diseases with an inflammatory component in pathogenesis, infections and need for hospitalization. Of the original 122 study participants, morbidity data at eight to eleven years was available for 101 participants, and 100 were enrolled in the study. A less anti-inflammatory Hp phenotype (Hp 2-2) was more prevalent in participants who suffered from diseases with an inflammatory component in their pathogenesis (RTI, pneumonia, UTI, OM and tonsillitis) when these entities were analyzed as a group (p=0.043). Subsequent comparison of the cumulative number of episodes of these entities between Hp phenotypes during all follow up period detected a trend in the same direction. Further research involving a larger population is required for better understanding of the Hp phenotype role in infantile and pediatric morbidity. VL - 6 IS - 1 ER -
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