American Journal of Pediatrics

| Peer-Reviewed |

Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children

Received: 17 January 2020    Accepted: 06 February 2020    Published: 18 February 2020
Views:       Downloads:

Share This Article

Abstract

The number of obesity in children and adolescents is increasing. Obese children are believed to experience chronic inflammation as evidenced by high levels of inflammatory markers, especially interleukin-6 (IL-6). Obese children have high incidence of anemia caused by inflammatory process proven by high level of serum hepcidin. This study aimed to investigate correlation between interleukin 6 with serum hepcidin in obese children, aged 6-10 years old whom were recruited consecutively from elementary schools in Denpasar from November 2016 until April 2017. Obesity was established using the Body Mass Index (BMI) measurements based on the CDC 2000 chart. The correlation between serum IL-6 and serum hepcidin was tested by using pearson test. Fifty-eight subjects in this study had mean Body Mass Index (BMI) 27.3 kg/m2. The mean interleukin-6 level was 3.1 gr with standard deviation (SD) 2.9 gr. Mean level of serum hepcidin 20.5 ng/ml, standard deviation (SD) 12.5 ng/ml. Pearson’s analysis test showed strong positive correlation between IL-6 level and hepcidin serum level (r=0.748; p=0.0001). Multivariate analysis by using partial analysis showed hepcidin correlate with IL-6 serum and BMI (r=0.737 and p=<0.001; r=0.385 and p=0.004, respectively). Bivariate analysis with matrix correlation showed weak correlation between IL-6 serum and BMI (p=0.289; r=0.028). This study found that IL-6 serum had strong positive correlation with hepcidin serum in obese children.

DOI 10.11648/j.ajp.20200601.14
Published in American Journal of Pediatrics (Volume 6, Issue 1, March 2020)
Page(s) 27-30
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Interleukin-6, Hepcidin, Obese, Children

References
[1] Riskesdas. 2010. Laporan Nasional 2013. Badan Penelitian dan Pengembangan Kesehatan Kementerian Kesehatan Republik Indonesia. h. 204-20.
[2] Gary, A., Soetjiningsih. Prevalence and risk factors of overweight and obesity in adolescents. Paediatr Indones. 2002; 42: 206-11.
[3] Ratna, M. D., Sidiartha, I. G. L. Prevalensi dan faktor risiko obesitas anak sekolah dasar di daerah urban dan rural. Medicin. 2013; 44: 15-21.
[4] Cardoso, M. A., Scope, K. K. G., Muniz, P. T., Villamor, E., Ferreira, M. U. Underlying factors associated with anemia in Amazonian children: A population-based, cross-sectional study. Plus One. 2012; 7 (5): 1-8.
[5] Shamah-Levy, T., Villalpando, S., Jauregui, A., Rivera, J. A. Overview of the nutritional status of selected micronutrients in Mexican children in 2006. Salad Publica de Mexico. 2012. 54 (2): 146-51.
[6] Arslan, N., Erdue, B., Aydin, A. Hormones and cytokines in childhood obesity. Indian Pediatr. 2010; 47: 829-39.
[7] Schwarzenberg, S. J., Sinaiko, A. R. Obesity and inflammation in children. Paediatr Respir Rev. 2006; 7: 239–46.
[8] Rocha, V. Z., Folco, E. J. Inflammatory concepts of obesity. Int J inflame. 2011; 20: 11-8.
[9] Kwapisz, J., Artur, S., Ewa, Z. Hepcidin and its role in iron homeostasis. EJIFCC. 2009; 20: 124-8.
[10] McClung, J. P, Karl, J. P. Iron deficiency and obesity: the contribution of inflamation and diminished iron absorption. Nutrition Reviews. 2009; 67: 100-4.
[11] Ganz, T., Nemeth, E. Hepcidin and Iron Homeostasis. Biochimica et Biophysica Acta. 2012; 1823: 1434-43.
[12] Baker, R. D., Greer, R. R. Diagnosis and prevention of iron deficiency and iron deficiency anemia in infants and young children (0-3 years of age). Pediatrics. 2010; 126; 1040-50.
[13] Rolland-Cachera, M. F., Deheeger, M., Maillot, M., Bellisle, F. Early adiposity rebond: causes and consequencies for obesity in children and adults. International Journal of Obesity. 2006; 30: S11-S17.
[14] Ridha, N. R., Daud, D. Hubungan kadar hepcidin dengan status besi pada inflamasi akibat obesitas. Sari pediatric. 2014; 16: 161-6.
[15] Żekanowska, E. Boinska, J. Giemza-Kucharska, P. Kwapisz, J. Obesity and low-grade inflamation: a paediatric perspective. J Biotechnol. 2011; 92: 147-152.
[16] Hamza, R. T., Hamed, A. I., Kharshoum, R. R.. Iron homeostasis and serum hepcidin-25 levels in obese children and adolescents: relation to body mass indeks. Horm Res Paediatr. 2013; 80: 11-7.
[17] De Filippo, G., Rendina, D., Moccia, F., Rocco, V., Campanozzi, A. Interleukin 6, soluble interleukin 6 receptor/interleukin 6 complex and insulin resistance in obese children and adolescents. J Endocrinol Invest. 2015; 38 (3): 339-43.
[18] Sánchez, A. F., Santillán, E. M., Bautista, M., Soto, J. E., González, A. M., Chirino, C. E. Inflammation, oxidative stress and obesity. Int J Mol Sci. 2011; 12: 3117-32.
[19] Gotera, W., Mahadita, W., Bakta, I. M., Oka, A. A. G., Budiartha, A. A. G., Manuaba, P., Maliawan, S. Waist circumference increased risk of benign prostatic hyperplasia through an increase in the level of interleukin-6 and insulin resistance in abdominal obesity patients. Bali Med J. 2017; 6 (1): 2014-20.
[20] Greenberg, A. S., Obin, M. S. Obesity and the role of adipose tissue in inflammation and metabolism. Am J Clin Nutr. 2006; 83: 461S–5S.
[21] Eder, K., Baffy, N., Falus, A. The major inflammatory mediator interleukin-6 and obesity. Inflamm. Res. 2009; 58: 727-36.
Author Information
  • Department of Child Health, Udayana University School of Medicine, Sanglah Hospital, Denpasar, Indonesia

  • Department of Child Health, Udayana University School of Medicine, Sanglah Hospital, Denpasar, Indonesia

  • Department of Child Health, Udayana University School of Medicine, Sanglah Hospital, Denpasar, Indonesia

Cite This Article
  • APA Style

    Ni Komang Diah Saputri, I Gusti Lanang Sidiartha, I Made Gede Dwi Lingga Utama. (2020). Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children. American Journal of Pediatrics, 6(1), 27-30. https://doi.org/10.11648/j.ajp.20200601.14

    Copy | Download

    ACS Style

    Ni Komang Diah Saputri; I Gusti Lanang Sidiartha; I Made Gede Dwi Lingga Utama. Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children. Am. J. Pediatr. 2020, 6(1), 27-30. doi: 10.11648/j.ajp.20200601.14

    Copy | Download

    AMA Style

    Ni Komang Diah Saputri, I Gusti Lanang Sidiartha, I Made Gede Dwi Lingga Utama. Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children. Am J Pediatr. 2020;6(1):27-30. doi: 10.11648/j.ajp.20200601.14

    Copy | Download

  • @article{10.11648/j.ajp.20200601.14,
      author = {Ni Komang Diah Saputri and I Gusti Lanang Sidiartha and I Made Gede Dwi Lingga Utama},
      title = {Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children},
      journal = {American Journal of Pediatrics},
      volume = {6},
      number = {1},
      pages = {27-30},
      doi = {10.11648/j.ajp.20200601.14},
      url = {https://doi.org/10.11648/j.ajp.20200601.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajp.20200601.14},
      abstract = {The number of obesity in children and adolescents is increasing. Obese children are believed to experience chronic inflammation as evidenced by high levels of inflammatory markers, especially interleukin-6 (IL-6). Obese children have high incidence of anemia caused by inflammatory process proven by high level of serum hepcidin. This study aimed to investigate correlation between interleukin 6 with serum hepcidin in obese children, aged 6-10 years old whom were recruited consecutively from elementary schools in Denpasar from November 2016 until April 2017. Obesity was established using the Body Mass Index (BMI) measurements based on the CDC 2000 chart. The correlation between serum IL-6 and serum hepcidin was tested by using pearson test. Fifty-eight subjects in this study had mean Body Mass Index (BMI) 27.3 kg/m2. The mean interleukin-6 level was 3.1 gr with standard deviation (SD) 2.9 gr. Mean level of serum hepcidin 20.5 ng/ml, standard deviation (SD) 12.5 ng/ml. Pearson’s analysis test showed strong positive correlation between IL-6 level and hepcidin serum level (r=0.748; p=0.0001). Multivariate analysis by using partial analysis showed hepcidin correlate with IL-6 serum and BMI (r=0.737 and p=<0.001; r=0.385 and p=0.004, respectively). Bivariate analysis with matrix correlation showed weak correlation between IL-6 serum and BMI (p=0.289; r=0.028). This study found that IL-6 serum had strong positive correlation with hepcidin serum in obese children.},
     year = {2020}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Correlation Between Interleukin-6 Serum and Hepcidin Serum in Obese Children
    AU  - Ni Komang Diah Saputri
    AU  - I Gusti Lanang Sidiartha
    AU  - I Made Gede Dwi Lingga Utama
    Y1  - 2020/02/18
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ajp.20200601.14
    DO  - 10.11648/j.ajp.20200601.14
    T2  - American Journal of Pediatrics
    JF  - American Journal of Pediatrics
    JO  - American Journal of Pediatrics
    SP  - 27
    EP  - 30
    PB  - Science Publishing Group
    SN  - 2472-0909
    UR  - https://doi.org/10.11648/j.ajp.20200601.14
    AB  - The number of obesity in children and adolescents is increasing. Obese children are believed to experience chronic inflammation as evidenced by high levels of inflammatory markers, especially interleukin-6 (IL-6). Obese children have high incidence of anemia caused by inflammatory process proven by high level of serum hepcidin. This study aimed to investigate correlation between interleukin 6 with serum hepcidin in obese children, aged 6-10 years old whom were recruited consecutively from elementary schools in Denpasar from November 2016 until April 2017. Obesity was established using the Body Mass Index (BMI) measurements based on the CDC 2000 chart. The correlation between serum IL-6 and serum hepcidin was tested by using pearson test. Fifty-eight subjects in this study had mean Body Mass Index (BMI) 27.3 kg/m2. The mean interleukin-6 level was 3.1 gr with standard deviation (SD) 2.9 gr. Mean level of serum hepcidin 20.5 ng/ml, standard deviation (SD) 12.5 ng/ml. Pearson’s analysis test showed strong positive correlation between IL-6 level and hepcidin serum level (r=0.748; p=0.0001). Multivariate analysis by using partial analysis showed hepcidin correlate with IL-6 serum and BMI (r=0.737 and p=<0.001; r=0.385 and p=0.004, respectively). Bivariate analysis with matrix correlation showed weak correlation between IL-6 serum and BMI (p=0.289; r=0.028). This study found that IL-6 serum had strong positive correlation with hepcidin serum in obese children.
    VL  - 6
    IS  - 1
    ER  - 

    Copy | Download

  • Sections