Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options

Zhendong Yang; Xuding Sun; Jihong Wu; Gaojun Zhou; Yingyang Xu; Xiong Xie; Kai Guan

doi:doi:10.11648/j.ajp.20190504.32

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Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options

Zhendong Yang, Xuding Sun, Jihong Wu, Gaojun Zhou, Yingyang Xu, Xiong Xie, Kai Guan

Published in American Journal of Pediatrics (Volume 5, Issue 4)

Received: 12 November 2019 Accepted: 12 December 2019 Published: 24 December 2019

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Abstract

Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.

Published in	American Journal of Pediatrics (Volume 5, Issue 4)
DOI	10.11648/j.ajp.20190504.32
Page(s)	291-298
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Vitamin D, VDD, Asthma, Children, Vitamin D Adjuvant Therapy

References

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Zhendong Yang, Xuding Sun, Jihong Wu, Gaojun Zhou, Yingyang Xu, et al. (2019). Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options. American Journal of Pediatrics, 5(4), 291-298. https://doi.org/10.11648/j.ajp.20190504.32

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ACS Style

Zhendong Yang; Xuding Sun; Jihong Wu; Gaojun Zhou; Yingyang Xu, et al. Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options. Am. J. Pediatr. 2019, 5(4), 291-298. doi: 10.11648/j.ajp.20190504.32

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AMA Style

Zhendong Yang, Xuding Sun, Jihong Wu, Gaojun Zhou, Yingyang Xu, et al. Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options. Am J Pediatr. 2019;5(4):291-298. doi: 10.11648/j.ajp.20190504.32

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@article{10.11648/j.ajp.20190504.32,
  author = {Zhendong Yang and Xuding Sun and Jihong Wu and Gaojun Zhou and Yingyang Xu and Xiong Xie and Kai Guan},
  title = {Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {4},
  pages = {291-298},
  doi = {10.11648/j.ajp.20190504.32},
  url = {https://doi.org/10.11648/j.ajp.20190504.32},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.32},
  abstract = {Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.},
 year = {2019}
}

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TY  - JOUR
T1  - Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options
AU  - Zhendong Yang
AU  - Xuding Sun
AU  - Jihong Wu
AU  - Gaojun Zhou
AU  - Yingyang Xu
AU  - Xiong Xie
AU  - Kai Guan
Y1  - 2019/12/24
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190504.32
DO  - 10.11648/j.ajp.20190504.32
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 291
EP  - 298
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190504.32
AB  - Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.
VL  - 5
IS  - 4
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Author Information

Zhendong Yang

Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China
Xuding Sun

Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China
Jihong Wu

Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China
Gaojun Zhou

Department of Respiratory Asthma, Beijing Jingdu Children's Hospital, Beijing, China
Yingyang Xu

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, China
Xiong Xie

Department of Pediatrics, Third Clinical Medical College of Three Gorges University (Gezhouba Central Hospital), Yichang, China
Kai Guan

Department of Allergy, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; Beijing Key Laboratory of Precision Medicine for Diagnosis and Treatment of Allergic Diseases, Clinical Immunology Center, Chinese Academy of Medical Sciences, Beijing, China

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Zhendong Yang, Xuding Sun, Jihong Wu, Gaojun Zhou, Yingyang Xu, et al. (2019). Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options. American Journal of Pediatrics, 5(4), 291-298. https://doi.org/10.11648/j.ajp.20190504.32

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Zhendong Yang; Xuding Sun; Jihong Wu; Gaojun Zhou; Yingyang Xu, et al. Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options. Am. J. Pediatr. 2019, 5(4), 291-298. doi: 10.11648/j.ajp.20190504.32

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AMA Style

Zhendong Yang, Xuding Sun, Jihong Wu, Gaojun Zhou, Yingyang Xu, et al. Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options. Am J Pediatr. 2019;5(4):291-298. doi: 10.11648/j.ajp.20190504.32

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@article{10.11648/j.ajp.20190504.32,
  author = {Zhendong Yang and Xuding Sun and Jihong Wu and Gaojun Zhou and Yingyang Xu and Xiong Xie and Kai Guan},
  title = {Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options},
  journal = {American Journal of Pediatrics},
  volume = {5},
  number = {4},
  pages = {291-298},
  doi = {10.11648/j.ajp.20190504.32},
  url = {https://doi.org/10.11648/j.ajp.20190504.32},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajp.20190504.32},
  abstract = {Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.},
 year = {2019}
}

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TY  - JOUR
T1  - Exploration of Vitamin D Supplementation Adjuvant Therapy for Childhood Asthma and the Best Treatment Options
AU  - Zhendong Yang
AU  - Xuding Sun
AU  - Jihong Wu
AU  - Gaojun Zhou
AU  - Yingyang Xu
AU  - Xiong Xie
AU  - Kai Guan
Y1  - 2019/12/24
PY  - 2019
N1  - https://doi.org/10.11648/j.ajp.20190504.32
DO  - 10.11648/j.ajp.20190504.32
T2  - American Journal of Pediatrics
JF  - American Journal of Pediatrics
JO  - American Journal of Pediatrics
SP  - 291
EP  - 298
PB  - Science Publishing Group
SN  - 2472-0909
UR  - https://doi.org/10.11648/j.ajp.20190504.32
AB  - Vitamin D not only promotes the health of human bones and muscles but also has an important impact on the metabolism of extraskeletal tissues. As a steroid hormone, vitamin D possesses important physiological functions, including cell differentiation and proliferation and immune regulation. Research has shown that vitamin D insufficiency (VDI) or vitamin D deficiency (VDD) can make children susceptible to asthma. Vitamin D has important immunoregulatory functions associated with preventing the occurrence of asthma or the worsening of its symptoms, improving lung function and enhancing glucocorticoid (GCS) action. An increasing number of randomized controlled intervention studies have confirmed that vitamin D affects the occurrence and development of asthmatic diseases. In recent years, accumulating laboratory and clinical research has supported the use of vitamin D as an adjuvant treatment for asthma and has achieved good clinical results. But the clinical outcome of vitamin D in the treatment of asthma is not as impressive as experimental studies. In addition to the complexity of clinical research, it may be related to clinical application methods. In order to combine theory with clinical practice, focused on exploring and selecting the most effective vitamin D adjuvant treatment of asthma, and comprehensively optimizing and applying these methods is beneficial to improve the therapeutic effect. However, there are different opinions regarding the results of the studies.
VL  - 5
IS  - 4
ER  -

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