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Post-Streptococcal Syndrome in a 5-Years Old Boy with Sever Vitamin D Deficiency Only Responding to Monoclonal Antibody: First Case Report
American Journal of Pediatrics
Volume 4, Issue 2, June 2018, Pages: 25-30
Received: Apr. 23, 2018; Accepted: May 16, 2018; Published: Jun. 12, 2018
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Authors
Sam Hassan, Department of Pediatrics, Mediclinic City Hospital, Dubai, United Arab Emirates
Farsheed Zakir, Department of Pediatrics, Mediclinic City Hospital, Dubai, United Arab Emirates
Sameer Sajwani, Department of Pediatrics, Mediclinic City Hospital, Dubai, United Arab Emirates
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Abstract
Despite the reduction in incidence of Group A Streptococcal (GAS) infections in the last few decades its global burden on mortality and morbidity remained significantly high and represent major concerns in many developing countries. These morbidities and mortalities can be serious in immunocompromised individuals. It has been shown for the last two decades that vitamin D plays an important role in the immune system modulation and its deficiency were associated with recurrent and sever infections. Only few literatures were written about the vitamin D deficiency and GAS infections and very scarce about its complications. One of the rarely reported complications of GAS infections is post-streptococcal systemic vasculitis. The association of this complications and the vitamin D deficiency was not reported before. We report for the first time a 5 years old boy presented with sever post-scarlet fever vasculitis with sever vitamin D deficiency, only responded to monoclonal antibody infusion. The presentation was complicated by more than one complications of GAS infection, hence difficult to diagnose initially and found to have sever vitamin D deficiency which we concluded is the causative factor for these complications. On correction of vitamin D level the deranged immunological and other factors causing the vasculitis were corrected subsequent to vitamin D correction. It is therefore recommended to check vitamin D concentration in cases of sever GAS especially in association with its complications such as the systemic vasculitis.
Keywords
Streptococcal Infection, Scarlet Fever, Vitamin D Deficiency, Vasculitis
To cite this article
Sam Hassan, Farsheed Zakir, Sameer Sajwani, Post-Streptococcal Syndrome in a 5-Years Old Boy with Sever Vitamin D Deficiency Only Responding to Monoclonal Antibody: First Case Report, American Journal of Pediatrics. Vol. 4, No. 2, 2018, pp. 25-30. doi: 10.11648/j.ajp.20180402.12
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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