Preparation of Stable Microemulsions with Different Droplet Size
American Journal of Nanosciences
Volume 5, Issue 4, December 2019, Pages: 76-82
Received: Nov. 7, 2019; Accepted: Nov. 28, 2019; Published: Dec. 10, 2019
Views 365      Downloads 112
Authors
Hu Shiyu, College of Materials and Chemistry, China Jiliang University, Hangzhou, China
Chen Jiaxuan, College of Materials and Chemistry, China Jiliang University, Hangzhou, China
Zhu Yeting, College of Materials and Chemistry, China Jiliang University, Hangzhou, China
Wei Yelu, College of Materials and Chemistry, China Jiliang University, Hangzhou, China
Di Tongtong, College of Materials and Chemistry, China Jiliang University, Hangzhou, China
Shen Hangyan, College of Materials and Chemistry, China Jiliang University, Hangzhou, China
Article Tools
Follow on us
Abstract
Microemulsion is a widely used technique for preparing nanoparticles. The droplet size in stable microemulsions is a key parameter for limiting the size and shape of the formed nanoparticles. In this paper, the stable microemulsions were synthesized by two titration methods, the water titration method and the co-surfactant titration. Six reagents with different HLB were used as surfactants, including Span-80, E-1302, EL-10, MOA-9, Triton X-114 and OP-10. Quasi ternary phase diagrams of O/W and W/O microemusions with different surfactants were established according to the composition of surfactant, co-surfactant, oil and water. The size of the microemulsions droplets was characterized by using Zetasizer Nano S90. Within the stable micromulsions region, the droplet size was systemically controlled from 1 nm to 120 nm by changing different surfactants and controlling the quality ratio of components. A complex dependence of the droplet size on the water to surfactant ratio and the co-surfactant to surfactant ratio was established. In the stable microemulsions region, the droplets size increases dramatically with increased the water to surfactant ratio and the larger droplet size is obtained with increasing the co-surfactant amount.
Keywords
Microemulsions, Quasi Ternary Phase, Droplet Size
To cite this article
Hu Shiyu, Chen Jiaxuan, Zhu Yeting, Wei Yelu, Di Tongtong, Shen Hangyan, Preparation of Stable Microemulsions with Different Droplet Size, American Journal of Nanosciences. Vol. 5, No. 4, 2019, pp. 76-82. doi: 10.11648/j.ajn.20190504.18
Copyright
Copyright © 2019 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
J. Ma and B. Wu, Effect of surfactants on preparation of nanoscale α-Al2O3 powders by oil-in-water microemulsion, Adv. Powder Technol. 24, 2013, 354-358.
[2]
D. Buceta, Y. Piñeiro, C. Vázquez-Vázquez, J. Rivas and M. López-Quintela. Metallic Clusters: Theoretical Background, Properties and Synthesis in Microemulsions. Catalysts, 2014, 4 (4): 356-374.
[3]
A. Nagy, J. P. Kennedy, P. Wang, C. Wesdemiotis and S. D. Hanton. Extent of coverage of surfaces treated with hydrophobizing microemulsions: A mass spectrometry and contact angle study. Applied Surface Science, 2006, 252 (10): 3751-3759.
[4]
P. Brown, A. Mohamed, T. Ardyani, S. E. Rogers and J. Eastoe. Magnetic and Phase Behavior of Magnetic Water-in-Oil Microemulsions. Journal of Surfactants & Detergents, 2017, 20: 1-6.
[5]
V. Volpe, D. S. Nascimento, M. Insausti and M. Grünhut. Octyl p-methoxycinnamate loaded microemulsion based on Ocimum basilicum, essential oil. Characterization and analytical studies for potential cosmetic applications. Colloids & Surfaces A Physicochemical & Engineering Aspects, 2018, 546: 285-292.
[6]
C. Souza C, L. A. Freitas. Topical Formulation Containing Beeswax-Based Nanoparticles Improved In Vivo, Skin Barrier Function. Aaps Pharmscitech, 2017, 18 (7): 1-12.
[7]
D. Pepe, J. Phelps, K. Lewis, J. Dujack, K. Scarlett, S. Jahan, E. Bonnier, T. Milic-Pasetto, M. A. Hass and L. B. Lopes. Decylglucoside-based microemulsions for cutaneous localization of lycopene and ascorbic acid. International Journal of Pharmaceutics, 2012, 434 (1-2): 420-428.
[8]
S. Talegaonkar, A. Azeem, F. J. Ahmad, R. K. Khar, S. A. Pathan and Z. I. Khan. Microemulsions: a novel approach to enhanced drug delivery. Recent Patents on Drug Delivery & Formulation, 2008, 2 (3): 238-295.
[9]
D. Senatra, C. Gambi, A. Neri and M. Vannini. Depolarization Current Analysis and Electrical Birefringence in Water-in-Oil Microemulsions. Developments in Biophysical Research. Springer US, 1980: 195-206.
[10]
N. Wang, L. Yang, L. Chen and R. Xiao. Study of the influence between magnesium ions and calcium ions on the morphology and size of coprecipitation in microemulsion. Surface Review & Letters, 2014, 9 (5): 302-307.
[11]
A. A. Derbina, A. V. Pirogov, I. D. Kargin and O. A. Shpigun. Application of water-in-oil microemulsions in microemulsion electrokinetic chromatography and as extractants of polar substances. Journal of Analytical Chemistry, 2015, 70 (10): 1271-1276.
[12]
Y. Ren Y, Y. Zhao Y, Y. Zhang, W. Tang, X. Xin, J. Shen and L. Wang. Facile synthesis of Au@SiO 2, core–shell nanoparticles with multiple Au nanodots by a reverse microemulsion (water-in-oil) method. Colloids & Surfaces A Physicochemical & Engineering Aspects, 2015, 486: 14-20.
[13]
M. R. Kaiser, Z. Ma, X. Wang, F. Han, T. Gao, X. Fan, J. Z. Wang, H.K. Liu, S. and C. Wang. Reverse Microemulsion Synthesis of Sulfur/Graphene Composite for Lithium/Sulfur Batteries. Acs Nano, 2017, 11 (9): 9048.
[14]
M. A. López-Quintela. Synthesis of nanomaterials in microemulsions: formation mechanisms and growth control. Current Opinion in Colloid & Interface Science, 2004, 8 (2): 137-144.
[15]
M. N. Krstajić Pajić, S. I. Stevanović, V. V. Radmilović, J. R. Rogan, V. R. Radmilović, S. L. Gojković and V. M. Jovanović. Pt/C nanocatalysts for methanol electrooxidation prepared by water-in-oil microemulsion method. Journal of Solid State Electrochemistry, 2016, 20 (12): 3405-3414.
[16]
R. Pichot, F. Spyropoulos and I. T. Norton. O/W emulsions stabilised by both low molecular weight surfactants and colloidal particles: The effect of surfactant type and concentration. J. Colloid Interface Sci 2010, 352: 128–135.
[17]
T. Charinpanitkul, A. Chanagul, J. Dutta, U. Rungsardthong and W. Tanthapanichakoon, Effects of cosurfactant on ZnS nanoparticle synthesis in microemulsion, Sci Technol Adv Mat, 6, 2005 266-271.
[18]
H. Araya, M. Tomita and M. Hayashi. The novel formulation design of O/W microemulsion for improving the gastrointestinal absorption of poorly water soluble compounds. Int J Pharm. 2005, 305 (1–2): 61–74.
ADDRESS
Science Publishing Group
1 Rockefeller Plaza,
10th and 11th Floors,
New York, NY 10020
U.S.A.
Tel: (001)347-983-5186