Design and evaluation of new chemically nano composites towards molecular imaging of malignant tumors is being considered as a kind of medical global research interests. In the current experiment novel nano-composite based on gadolinium ions and anionic linear globular Dendrimer G2 (as biocompatible biodegradable hybrid nanomaterial grafted to folic acid was developed and biophysically assayed. The results showed a very good Magnetic Resonance (MR) relaxivity data on T2 decreasing as well as a very good cellular uptake and tolerance. The complex was found toxic with employing apoptosis as main mechanism of action on cancerous cells respectively. Based on results it could be concluded that such nano-complex may be used as novel theranostic agent in further in vivo practices in near future.
| Published in | American Journal of Nanosciences (Volume 3, Issue 1) |
| DOI | 10.11648/j.ajn.20170301.12 |
| Page(s) | 9-18 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Folic Acid, Gadolinium, Anionic Linear Globular Dendrimer G2, Magnetic Resonance
| [1] | Na, H. B., I. C. Song, and T. Hyeon, Inorganic nanoparticles for MRI contrast agents. Advanced Materials, 2009. 21 (21): p. 2133-2148. |
| [2] | Lodhia, J., et al., Development and use of iron oxide nanoparticles (Part 1): Synthesis of iron oxide nanoparticles for MRI. Biomedical imaging and intervention journal, 2010. 6 (2): p. e12. |
| [3] | Wang, S. H., et al., Dendrimer-Functionalized Iron Oxide Nanoparticles for Specific Targeting and Imaging of Cancer Cells. Advanced Functional Materials, 2007. 17 (16): p. 3043-3050. |
| [4] | Peng, X.-H., et al., Targeted magnetic iron oxide nanoparticles for tumor imaging and therapy. International journal of nanomedicine, 2008. 3 (3): p. 311. |
| [5] | Choi, H., et al., Iron oxide nanoparticles as magnetic resonance contrast agent for tumor imaging via folate receptor-targeted delivery 1. Academic radiology, 2004. 11 (9): p. 996-1004. |
| [6] | Arsalani, N., H. Fattahi, and M. Nazarpoor, Synthesis and characterization of PVP-functionalized superparamagnetic Fe3O4 nanoparticles as an MRI contrast agent. Express Polym Lett, 2010. 4 (6): p. 329-38. |
| [7] | Tomalia, D., L. Reyna, and S. Svenson, Dendrimers as multi-purpose nanodevices for oncology drug delivery and diagnostic imaging. Biochemical Society Transactions, 2007. 35 (1): p. 61. |
| [8] | Landmark, K. J., et al., Synthesis, characterization, and in vitro testing of superparamagnetic iron oxide nanoparticles targeted using folic acid-conjugated dendrimers. ACS nano, 2008. 2 (4): p. 773-783. |
| [9] | Rosen, J. E., et al., Iron oxide nanoparticles for targeted cancer imaging and diagnostics. Nanomedicine: Nanotechnology, Biology and Medicine, 2012. 8 (3): p. 275-290. |
| [10] | Swanson, S. D., et al., Targeted gadolinium-loaded dendrimer nanoparticles for tumor-specific magnetic resonance contrast enhancement. International journal of nanomedicine, 2008. 3 (2): p. 201. |
| [11] | Ardestani, M. S., et al., Nanosilver based anionic linear globular dendrimer with a special significant antiretroviral activity. Journal of Materials Science: Materials in Medicine, 2015. 26 (5): p. 1-8. |
| [12] | Karimi, N., et al., Anionic Linear Globular Dendrimer-G2-Ciprofloxacin Nano-Conjugate: Novel Agent against Wilson Disease Cell Model. Letters in Drug Design & Discovery, 2014. 11 (7): p. 908-916. |
APA Style
Saeed Akbarian, Asma Keshavarz, Esmaeel Mohammadi Pargoo, Nasser Nassiri Koopaei, Hamid Moloudian, et al. (2017). Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent. American Journal of Nanosciences, 3(1), 9-18. https://doi.org/10.11648/j.ajn.20170301.12
ACS Style
Saeed Akbarian; Asma Keshavarz; Esmaeel Mohammadi Pargoo; Nasser Nassiri Koopaei; Hamid Moloudian, et al. Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent. Am. J. Nanosci. 2017, 3(1), 9-18. doi: 10.11648/j.ajn.20170301.12
AMA Style
Saeed Akbarian, Asma Keshavarz, Esmaeel Mohammadi Pargoo, Nasser Nassiri Koopaei, Hamid Moloudian, et al. Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent. Am J Nanosci. 2017;3(1):9-18. doi: 10.11648/j.ajn.20170301.12
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Download@article{10.11648/j.ajn.20170301.12,
author = {Saeed Akbarian and Asma Keshavarz and Esmaeel Mohammadi Pargoo and Nasser Nassiri Koopaei and Hamid Moloudian and Mostafa Saffari and Hadi Hejazinia and Masood Bamedi and Mehdi Shafiee Ardestani},
title = {Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent},
journal = {American Journal of Nanosciences},
volume = {3},
number = {1},
pages = {9-18},
doi = {10.11648/j.ajn.20170301.12},
url = {https://doi.org/10.11648/j.ajn.20170301.12},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajn.20170301.12},
abstract = {Design and evaluation of new chemically nano composites towards molecular imaging of malignant tumors is being considered as a kind of medical global research interests. In the current experiment novel nano-composite based on gadolinium ions and anionic linear globular Dendrimer G2 (as biocompatible biodegradable hybrid nanomaterial grafted to folic acid was developed and biophysically assayed. The results showed a very good Magnetic Resonance (MR) relaxivity data on T2 decreasing as well as a very good cellular uptake and tolerance. The complex was found toxic with employing apoptosis as main mechanism of action on cancerous cells respectively. Based on results it could be concluded that such nano-complex may be used as novel theranostic agent in further in vivo practices in near future.},
year = {2017}
}
TY - JOUR T1 - Original Research Article Novel Nano-Sized Iron Complex Application Using Folate Based Imaging Agent AU - Saeed Akbarian AU - Asma Keshavarz AU - Esmaeel Mohammadi Pargoo AU - Nasser Nassiri Koopaei AU - Hamid Moloudian AU - Mostafa Saffari AU - Hadi Hejazinia AU - Masood Bamedi AU - Mehdi Shafiee Ardestani Y1 - 2017/03/30 PY - 2017 N1 - https://doi.org/10.11648/j.ajn.20170301.12 DO - 10.11648/j.ajn.20170301.12 T2 - American Journal of Nanosciences JF - American Journal of Nanosciences JO - American Journal of Nanosciences SP - 9 EP - 18 PB - Science Publishing Group SN - 2575-4858 UR - https://doi.org/10.11648/j.ajn.20170301.12 AB - Design and evaluation of new chemically nano composites towards molecular imaging of malignant tumors is being considered as a kind of medical global research interests. In the current experiment novel nano-composite based on gadolinium ions and anionic linear globular Dendrimer G2 (as biocompatible biodegradable hybrid nanomaterial grafted to folic acid was developed and biophysically assayed. The results showed a very good Magnetic Resonance (MR) relaxivity data on T2 decreasing as well as a very good cellular uptake and tolerance. The complex was found toxic with employing apoptosis as main mechanism of action on cancerous cells respectively. Based on results it could be concluded that such nano-complex may be used as novel theranostic agent in further in vivo practices in near future. VL - 3 IS - 1 ER -
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