European Journal of Clinical and Biomedical Sciences

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Expression of Vimentin in Spinal Cord Injury

Received: 28 December 2019    Accepted: 06 January 2020    Published: 17 January 2020
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Abstract

This study is to explore the expression differences of vimentin in the normal spinal cord tissues and the injured spinal cord tissues. The 15 SD rats were randomly divided into two experimental groups and sham group. Acute spinal cord injury models in experimental groups were performed with Lisa method and the injured spinal cord was collected after getting injured 72h. The method of immunohistochemical stain was applied to observe the expressions of vimentin in the normal spinal cord tissue and the injured spinal cord tissue of rats. The results showed the expression of vimentin was found in both the grey matter and white matter of the spinal cord of rats with a relatively even distribution. In addition, the protein expressions of vimentin in the medium injury group and the severe injury group were obviously higher than the sham group. In conclusion, expressions of vimentin were found in the spinal cord, and expression differences were observed after the spinal cord injury, which indicated that vimentin might play a part in the injured process of the spinal cord. It is poised to be a phase of advancement in the treatment of acute spinal cord injury and the importance of further elucidation of underlying pathophysiological mechanisms of vimentin.

DOI 10.11648/j.ejcbs.20200601.12
Published in European Journal of Clinical and Biomedical Sciences (Volume 6, Issue 1, February 2020)
Page(s) 5-8
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Vimentin, Spinal Cord Injury, Protein Expression

References
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[3] Duncan EJ, Lariviere R, Bradshaw TY, et al. Altered organization of the intermediate filament cytoskeleton and relocalization of proteostasis modulators in cells lacking the ataxia protein sacsin. Human molecular genetics 2017, 26 (16): 3130-3143.
[4] De Souza PC, Katz SG. Coexpression of cytokeratin and vimentin in mice trophoblastic giant cells. Tissue & cell 2001, 33 (1): 40-45.
[5] Ko SH, Suh SH, Kim BJ, et al. Expression of the intermediate filament vimentin in proliferating duct cells as a marker of pancreatic precursor cells. Pancreas 2004, 28 (2): 121-128.
[6] Benes P, Maceckova V, Zdrahal Z, et al. Role of vimentin in regulation of monocyte/macrophage differentiation. Differentiation; research in biological diversity 2006, 74 (6): 265-276.
[7] Dumont AS, Dumont RJ, Oskouian RJ. Will improved understanding of the pathophysiological mechanisms involved in acute spinal cord injury improve the potential for therapeutic intervention? Current opinion in neurology 2002, 15 (6): 713-720.
[8] Werner HB, Nave KA. Enhanced Actin Dynamics: A Therapeutic Strategy for Axonal Regeneration? Neuron 2019, 103 (6): 949-950.
[9] Hol EM, Capetanaki Y. Type III Intermediate Filaments Desmin, Glial Fibrillary Acidic Protein (GFAP), Vimentin, and Peripherin. Cold Spring Harbor perspectives in biology 2017, 9 (12).
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Author Information
  • Department of Orthopaedics, the 909th Hospital of PLA, Affiliated Southeast Hospital of Xiamen University, Orthopaedic Center of People's Liberation Army, Zhangzhou, China

  • Department of Orthopaedics, the 909th Hospital of PLA, Affiliated Southeast Hospital of Xiamen University, Orthopaedic Center of People's Liberation Army, Zhangzhou, China

  • Department of Orthopaedics, the 909th Hospital of PLA, Affiliated Southeast Hospital of Xiamen University, Orthopaedic Center of People's Liberation Army, Zhangzhou, China

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    Huang Yumin, Zhou Liang, Lin Weichang. (2020). Expression of Vimentin in Spinal Cord Injury. European Journal of Clinical and Biomedical Sciences, 6(1), 5-8. https://doi.org/10.11648/j.ejcbs.20200601.12

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    ACS Style

    Huang Yumin; Zhou Liang; Lin Weichang. Expression of Vimentin in Spinal Cord Injury. Eur. J. Clin. Biomed. Sci. 2020, 6(1), 5-8. doi: 10.11648/j.ejcbs.20200601.12

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    AMA Style

    Huang Yumin, Zhou Liang, Lin Weichang. Expression of Vimentin in Spinal Cord Injury. Eur J Clin Biomed Sci. 2020;6(1):5-8. doi: 10.11648/j.ejcbs.20200601.12

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  • @article{10.11648/j.ejcbs.20200601.12,
      author = {Huang Yumin and Zhou Liang and Lin Weichang},
      title = {Expression of Vimentin in Spinal Cord Injury},
      journal = {European Journal of Clinical and Biomedical Sciences},
      volume = {6},
      number = {1},
      pages = {5-8},
      doi = {10.11648/j.ejcbs.20200601.12},
      url = {https://doi.org/10.11648/j.ejcbs.20200601.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ejcbs.20200601.12},
      abstract = {This study is to explore the expression differences of vimentin in the normal spinal cord tissues and the injured spinal cord tissues. The 15 SD rats were randomly divided into two experimental groups and sham group. Acute spinal cord injury models in experimental groups were performed with Lisa method and the injured spinal cord was collected after getting injured 72h. The method of immunohistochemical stain was applied to observe the expressions of vimentin in the normal spinal cord tissue and the injured spinal cord tissue of rats. The results showed the expression of vimentin was found in both the grey matter and white matter of the spinal cord of rats with a relatively even distribution. In addition, the protein expressions of vimentin in the medium injury group and the severe injury group were obviously higher than the sham group. In conclusion, expressions of vimentin were found in the spinal cord, and expression differences were observed after the spinal cord injury, which indicated that vimentin might play a part in the injured process of the spinal cord. It is poised to be a phase of advancement in the treatment of acute spinal cord injury and the importance of further elucidation of underlying pathophysiological mechanisms of vimentin.},
     year = {2020}
    }
    

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  • TY  - JOUR
    T1  - Expression of Vimentin in Spinal Cord Injury
    AU  - Huang Yumin
    AU  - Zhou Liang
    AU  - Lin Weichang
    Y1  - 2020/01/17
    PY  - 2020
    N1  - https://doi.org/10.11648/j.ejcbs.20200601.12
    DO  - 10.11648/j.ejcbs.20200601.12
    T2  - European Journal of Clinical and Biomedical Sciences
    JF  - European Journal of Clinical and Biomedical Sciences
    JO  - European Journal of Clinical and Biomedical Sciences
    SP  - 5
    EP  - 8
    PB  - Science Publishing Group
    SN  - 2575-5005
    UR  - https://doi.org/10.11648/j.ejcbs.20200601.12
    AB  - This study is to explore the expression differences of vimentin in the normal spinal cord tissues and the injured spinal cord tissues. The 15 SD rats were randomly divided into two experimental groups and sham group. Acute spinal cord injury models in experimental groups were performed with Lisa method and the injured spinal cord was collected after getting injured 72h. The method of immunohistochemical stain was applied to observe the expressions of vimentin in the normal spinal cord tissue and the injured spinal cord tissue of rats. The results showed the expression of vimentin was found in both the grey matter and white matter of the spinal cord of rats with a relatively even distribution. In addition, the protein expressions of vimentin in the medium injury group and the severe injury group were obviously higher than the sham group. In conclusion, expressions of vimentin were found in the spinal cord, and expression differences were observed after the spinal cord injury, which indicated that vimentin might play a part in the injured process of the spinal cord. It is poised to be a phase of advancement in the treatment of acute spinal cord injury and the importance of further elucidation of underlying pathophysiological mechanisms of vimentin.
    VL  - 6
    IS  - 1
    ER  - 

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