International Journal of Biomedical Engineering and Clinical Science

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Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds

Received: 08 March 2018    Accepted: 24 March 2018    Published: 12 April 2018
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Abstract

The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium timorense seeds on the blood glucose level. In addition, the effect of the plant extract on the lipid profile was determined by measuring serum total lipids (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Furthermore, the bioactive compounds were isolated and identified by chromatographic and spectrometric methods. The results showed that the methanolic extract of the seeds significantly reduced the levels of blood glucose, (TL), (TC), (TG) and (LDL-C) but no significant effect on (HDL-C) by comparing with control group. Furthermore, four phenolic compound were isolated which were identified as; catechin, gallic acid, paramethoxybenzaldehyde and pyrogallol which were isolated for the first time from the seeds of the plant. In addition sulphur -containing compound (sulpholane) was isolated for the first time from the plant and from the family. To our knowledge, this is the first study about antihyperglycaemic and antihyperlipidemic activities of the seeds of Pleiogynium timorense and its bioactive compounds. So, the methanolic extract of the seeds of Pleiogynium timorense could be a step towards the development of new antihyperglycaemic and antihyperlipidemic drugs.

DOI 10.11648/j.ijbecs.20180402.11
Published in International Journal of Biomedical Engineering and Clinical Science (Volume 4, Issue 2, June 2018)
Page(s) 30-35
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Antihyperglycaemic, Bioactive Compounds, Phenolic, Pleiogynium timorense, Seeds

References
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Author Information
  • Pharmacognosy Department, National Research Centre, Giza, Egypt

  • Pharmacognosy Department, Faculty of Pharmacy, Cairo University, Cairo, Egypt

  • Pharmacognosy Department, National Research Centre, Giza, Egypt

  • Internal Medicine Department, Medical Division, National Research Centre, Giza, Egypt

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    Ataa Said, Elsayed Ali Abuotabl, Gehan Fawzy Abdel Raoof, Khaled Younes Mohamed. (2018). Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds. International Journal of Biomedical Engineering and Clinical Science, 4(2), 30-35. https://doi.org/10.11648/j.ijbecs.20180402.11

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    ACS Style

    Ataa Said; Elsayed Ali Abuotabl; Gehan Fawzy Abdel Raoof; Khaled Younes Mohamed. Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds. Int. J. Biomed. Eng. Clin. Sci. 2018, 4(2), 30-35. doi: 10.11648/j.ijbecs.20180402.11

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    AMA Style

    Ataa Said, Elsayed Ali Abuotabl, Gehan Fawzy Abdel Raoof, Khaled Younes Mohamed. Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds. Int J Biomed Eng Clin Sci. 2018;4(2):30-35. doi: 10.11648/j.ijbecs.20180402.11

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  • @article{10.11648/j.ijbecs.20180402.11,
      author = {Ataa Said and Elsayed Ali Abuotabl and Gehan Fawzy Abdel Raoof and Khaled Younes Mohamed},
      title = {Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds},
      journal = {International Journal of Biomedical Engineering and Clinical Science},
      volume = {4},
      number = {2},
      pages = {30-35},
      doi = {10.11648/j.ijbecs.20180402.11},
      url = {https://doi.org/10.11648/j.ijbecs.20180402.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijbecs.20180402.11},
      abstract = {The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium timorense seeds on the blood glucose level. In addition, the effect of the plant extract on the lipid profile was determined by measuring serum total lipids (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Furthermore, the bioactive compounds were isolated and identified by chromatographic and spectrometric methods. The results showed that the methanolic extract of the seeds significantly reduced the levels of blood glucose, (TL), (TC), (TG) and (LDL-C) but no significant effect on (HDL-C) by comparing with control group. Furthermore, four phenolic compound were isolated which were identified as; catechin, gallic acid, paramethoxybenzaldehyde and pyrogallol which were isolated for the first time from the seeds of the plant. In addition sulphur -containing compound (sulpholane) was isolated for the first time from the plant and from the family. To our knowledge, this is the first study about antihyperglycaemic and antihyperlipidemic activities of the seeds of Pleiogynium timorense and its bioactive compounds. So, the methanolic extract of the seeds of Pleiogynium timorense could be a step towards the development of new antihyperglycaemic and antihyperlipidemic drugs.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Antihyperglycaemic and Antihyperlipidemic Activities of Pleiogynium timorense Seeds and Identification of Bioactive Compounds
    AU  - Ataa Said
    AU  - Elsayed Ali Abuotabl
    AU  - Gehan Fawzy Abdel Raoof
    AU  - Khaled Younes Mohamed
    Y1  - 2018/04/12
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ijbecs.20180402.11
    DO  - 10.11648/j.ijbecs.20180402.11
    T2  - International Journal of Biomedical Engineering and Clinical Science
    JF  - International Journal of Biomedical Engineering and Clinical Science
    JO  - International Journal of Biomedical Engineering and Clinical Science
    SP  - 30
    EP  - 35
    PB  - Science Publishing Group
    SN  - 2472-1301
    UR  - https://doi.org/10.11648/j.ijbecs.20180402.11
    AB  - The aim of this study is to evaluate antihyperglycaemi cand antihyperlipidemic activities of Pleiogynium timorense (DC.) Leenh (Anacardiaceae) seeds as well as to isolate and identify the bioactive compounds. Antihyperglycaemic effect was evaluated by measuring the effect of two dose levels (150 and 300 mg/kg) of 70% methanol extract of Pleiogynium timorense seeds on the blood glucose level. In addition, the effect of the plant extract on the lipid profile was determined by measuring serum total lipids (TL), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Furthermore, the bioactive compounds were isolated and identified by chromatographic and spectrometric methods. The results showed that the methanolic extract of the seeds significantly reduced the levels of blood glucose, (TL), (TC), (TG) and (LDL-C) but no significant effect on (HDL-C) by comparing with control group. Furthermore, four phenolic compound were isolated which were identified as; catechin, gallic acid, paramethoxybenzaldehyde and pyrogallol which were isolated for the first time from the seeds of the plant. In addition sulphur -containing compound (sulpholane) was isolated for the first time from the plant and from the family. To our knowledge, this is the first study about antihyperglycaemic and antihyperlipidemic activities of the seeds of Pleiogynium timorense and its bioactive compounds. So, the methanolic extract of the seeds of Pleiogynium timorense could be a step towards the development of new antihyperglycaemic and antihyperlipidemic drugs.
    VL  - 4
    IS  - 2
    ER  - 

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