Green Protocol for the Synthesis of Catalyst Free Biginelli Products

Abdul Ghafoor; Naved Sajid; Muhammad Adnan; Muhammad Naeem Khan; Amin Abid; Ansa Madeeha Zafar; Muhammad Ahmad; Noreen Aslam; Mussarat Jabeen; Amjad Ali; Misbahul Ain Khan

doi:doi:10.11648/j.ajhc.20200601.11

Green Protocol for the Synthesis of Catalyst Free Biginelli Products

Abdul Ghafoor, Naved Sajid, Muhammad Adnan, Muhammad Naeem Khan, Amin Abid, Ansa Madeeha Zafar, Muhammad Ahmad, Noreen Aslam, Mussarat Jabeen, Amjad Ali, Misbahul Ain Khan

Published in American Journal of Heterocyclic Chemistry (Volume 6, Issue 1)

Received: 5 September 2019 Accepted: 26 April 2020 Published: 28 May 2020

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Abstract

Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.

Published in	American Journal of Heterocyclic Chemistry (Volume 6, Issue 1)
DOI	10.11648/j.ajhc.20200601.11
Page(s)	1-5
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Green Chemistry, 3, 4-Dihydropyrimidones, 3, 4-Dihydropyrimidothiones, Multi Component, Synthetic Methods, One pot, Catalyst Free Reactions

References

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APA Style

Abdul Ghafoor, Naved Sajid, Muhammad Adnan, Muhammad Naeem Khan, Amin Abid, et al. (2020). Green Protocol for the Synthesis of Catalyst Free Biginelli Products. American Journal of Heterocyclic Chemistry, 6(1), 1-5. https://doi.org/10.11648/j.ajhc.20200601.11

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ACS Style

Abdul Ghafoor; Naved Sajid; Muhammad Adnan; Muhammad Naeem Khan; Amin Abid, et al. Green Protocol for the Synthesis of Catalyst Free Biginelli Products. Am. J. Heterocycl. Chem. 2020, 6(1), 1-5. doi: 10.11648/j.ajhc.20200601.11

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AMA Style

Abdul Ghafoor, Naved Sajid, Muhammad Adnan, Muhammad Naeem Khan, Amin Abid, et al. Green Protocol for the Synthesis of Catalyst Free Biginelli Products. Am J Heterocycl Chem. 2020;6(1):1-5. doi: 10.11648/j.ajhc.20200601.11

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@article{10.11648/j.ajhc.20200601.11,
  author = {Abdul Ghafoor and Naved Sajid and Muhammad Adnan and Muhammad Naeem Khan and Amin Abid and Ansa Madeeha Zafar and Muhammad Ahmad and Noreen Aslam and Mussarat Jabeen and Amjad Ali and Misbahul Ain Khan},
  title = {Green Protocol for the Synthesis of Catalyst Free Biginelli Products},
  journal = {American Journal of Heterocyclic Chemistry},
  volume = {6},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ajhc.20200601.11},
  url = {https://doi.org/10.11648/j.ajhc.20200601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20200601.11},
  abstract = {Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.},
 year = {2020}
}

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TY  - JOUR
T1  - Green Protocol for the Synthesis of Catalyst Free Biginelli Products
AU  - Abdul Ghafoor
AU  - Naved Sajid
AU  - Muhammad Adnan
AU  - Muhammad Naeem Khan
AU  - Amin Abid
AU  - Ansa Madeeha Zafar
AU  - Muhammad Ahmad
AU  - Noreen Aslam
AU  - Mussarat Jabeen
AU  - Amjad Ali
AU  - Misbahul Ain Khan
Y1  - 2020/05/28
PY  - 2020
N1  - https://doi.org/10.11648/j.ajhc.20200601.11
DO  - 10.11648/j.ajhc.20200601.11
T2  - American Journal of Heterocyclic Chemistry
JF  - American Journal of Heterocyclic Chemistry
JO  - American Journal of Heterocyclic Chemistry
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2575-5722
UR  - https://doi.org/10.11648/j.ajhc.20200601.11
AB  - Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.
VL  - 6
IS  - 1
ER  -

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Author Information

Abdul Ghafoor

Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan
Naved Sajid

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Muhammad Adnan

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan
Muhammad Naeem Khan

Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan
Amin Abid

Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan
Ansa Madeeha Zafar

Department of Chemistry, The Women University, Bahawalpur, Pakistan
Muhammad Ahmad

Department of Chemistry, University of Sahiwal, Sahiwal, Pakistan
Noreen Aslam

Department of Chemistry, The Women University, Bahawalpur, Pakistan
Mussarat Jabeen

Department of Chemistry, The Women University, Bahawalpur, Pakistan
Amjad Ali

Department of Anatomy, CMH Institute of Medical Sciences, Multan, Pakistan
Misbahul Ain Khan

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur, Pakistan

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APA Style

Abdul Ghafoor, Naved Sajid, Muhammad Adnan, Muhammad Naeem Khan, Amin Abid, et al. (2020). Green Protocol for the Synthesis of Catalyst Free Biginelli Products. American Journal of Heterocyclic Chemistry, 6(1), 1-5. https://doi.org/10.11648/j.ajhc.20200601.11

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ACS Style

Abdul Ghafoor; Naved Sajid; Muhammad Adnan; Muhammad Naeem Khan; Amin Abid, et al. Green Protocol for the Synthesis of Catalyst Free Biginelli Products. Am. J. Heterocycl. Chem. 2020, 6(1), 1-5. doi: 10.11648/j.ajhc.20200601.11

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AMA Style

Abdul Ghafoor, Naved Sajid, Muhammad Adnan, Muhammad Naeem Khan, Amin Abid, et al. Green Protocol for the Synthesis of Catalyst Free Biginelli Products. Am J Heterocycl Chem. 2020;6(1):1-5. doi: 10.11648/j.ajhc.20200601.11

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@article{10.11648/j.ajhc.20200601.11,
  author = {Abdul Ghafoor and Naved Sajid and Muhammad Adnan and Muhammad Naeem Khan and Amin Abid and Ansa Madeeha Zafar and Muhammad Ahmad and Noreen Aslam and Mussarat Jabeen and Amjad Ali and Misbahul Ain Khan},
  title = {Green Protocol for the Synthesis of Catalyst Free Biginelli Products},
  journal = {American Journal of Heterocyclic Chemistry},
  volume = {6},
  number = {1},
  pages = {1-5},
  doi = {10.11648/j.ajhc.20200601.11},
  url = {https://doi.org/10.11648/j.ajhc.20200601.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajhc.20200601.11},
  abstract = {Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.},
 year = {2020}
}

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TY  - JOUR
T1  - Green Protocol for the Synthesis of Catalyst Free Biginelli Products
AU  - Abdul Ghafoor
AU  - Naved Sajid
AU  - Muhammad Adnan
AU  - Muhammad Naeem Khan
AU  - Amin Abid
AU  - Ansa Madeeha Zafar
AU  - Muhammad Ahmad
AU  - Noreen Aslam
AU  - Mussarat Jabeen
AU  - Amjad Ali
AU  - Misbahul Ain Khan
Y1  - 2020/05/28
PY  - 2020
N1  - https://doi.org/10.11648/j.ajhc.20200601.11
DO  - 10.11648/j.ajhc.20200601.11
T2  - American Journal of Heterocyclic Chemistry
JF  - American Journal of Heterocyclic Chemistry
JO  - American Journal of Heterocyclic Chemistry
SP  - 1
EP  - 5
PB  - Science Publishing Group
SN  - 2575-5722
UR  - https://doi.org/10.11648/j.ajhc.20200601.11
AB  - Applications of multicomponent reactions (MCRs) in the preparation of diverse types of heterocyclic compounds carries a unique place in chemical synthesis. Biginelli reaction, among the loop of multicomponent reactions, provide an efficient way to access of highly functionalized dihydropyrimidones (-thiones) (DHPMs). In the current study, we employed multicomponent Biginelli reaction to synthesis range of different dihydropyrimidones (-thiones) derivatives in variable yields. A solvent-free eco-friendly green protocol without any expensive catalyst has been optimized and expand to synthesize series of DHMPS in 34 to 72% yield. The optimized method proved to be successful with various types of different aromatic aldehydes, 1, 3-dicarbonyl compounds and urea (thiourea) under solvent and catalyst free condition to access dihydropyrimidones (thiones). Different spectroscopic techniques include NMR, FTIR etc. have used to confirm the structures of compounds. Further exploration of Biginelli reaction to prepare DHPMs and related compounds is under way in the lab and will be published in due course.
VL  - 6
IS  - 1
ER  -

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