Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Arasch Bareksei; Gerd Hafner; Sebastian Pfeiffer; Kathrin Schlatterer

doi:doi:10.11648/j.ijcems.20190505.13

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Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 5)

Received: 6 September 2019 Accepted: 24 September 2019 Published: 17 October 2019

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Abstract

A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3-fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of in-vitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.

Published in	International Journal of Clinical and Experimental Medical Sciences (Volume 5, Issue 5)
DOI	10.11648/j.ijcems.20190505.13
Page(s)	70-79
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Omega-3-Fatty Acid Supplementation, In Vitro Fertilization, Immunological Laboratory Status

References

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APA Style

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. (2019). Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment. International Journal of Clinical and Experimental Medical Sciences, 5(5), 70-79. https://doi.org/10.11648/j.ijcems.20190505.13

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ACS Style

Arasch Bareksei; Gerd Hafner; Sebastian Pfeiffer; Kathrin Schlatterer. Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment. Int. J. Clin. Exp. Med. Sci. 2019, 5(5), 70-79. doi: 10.11648/j.ijcems.20190505.13

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AMA Style

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment. Int J Clin Exp Med Sci. 2019;5(5):70-79. doi: 10.11648/j.ijcems.20190505.13

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@article{10.11648/j.ijcems.20190505.13,
  author = {Arasch Bareksei and Gerd Hafner and Sebastian Pfeiffer and Kathrin Schlatterer},
  title = {Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {5},
  number = {5},
  pages = {70-79},
  doi = {10.11648/j.ijcems.20190505.13},
  url = {https://doi.org/10.11648/j.ijcems.20190505.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190505.13},
  abstract = {A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3-fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of in-vitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.},
 year = {2019}
}

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TY  - JOUR
T1  - Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment
AU  - Arasch Bareksei
AU  - Gerd Hafner
AU  - Sebastian Pfeiffer
AU  - Kathrin Schlatterer
Y1  - 2019/10/17
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcems.20190505.13
DO  - 10.11648/j.ijcems.20190505.13
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 70
EP  - 79
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20190505.13
AB  - A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3-fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of in-vitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.
VL  - 5
IS  - 5
ER  -

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Author Information

Arasch Bareksei

Dental Concept, Voerde, Germany
Gerd Hafner

Institut Für Laboratoriumsmedizin, Mikrobiologie Und Hygiene, Evangelisches Klinikum Bethel, Bielefeld, Germany
Sebastian Pfeiffer

Labor Todorov, Düsseldorf, Germany
Kathrin Schlatterer

Departments of Dermatology, Venereology, Allergology and Immunology, Brandenburg Medical School Theodor Fontane, Dessau, Germany

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APA Style

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. (2019). Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment. International Journal of Clinical and Experimental Medical Sciences, 5(5), 70-79. https://doi.org/10.11648/j.ijcems.20190505.13

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ACS Style

Arasch Bareksei; Gerd Hafner; Sebastian Pfeiffer; Kathrin Schlatterer. Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment. Int. J. Clin. Exp. Med. Sci. 2019, 5(5), 70-79. doi: 10.11648/j.ijcems.20190505.13

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AMA Style

Arasch Bareksei, Gerd Hafner, Sebastian Pfeiffer, Kathrin Schlatterer. Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment. Int J Clin Exp Med Sci. 2019;5(5):70-79. doi: 10.11648/j.ijcems.20190505.13

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@article{10.11648/j.ijcems.20190505.13,
  author = {Arasch Bareksei and Gerd Hafner and Sebastian Pfeiffer and Kathrin Schlatterer},
  title = {Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment},
  journal = {International Journal of Clinical and Experimental Medical Sciences},
  volume = {5},
  number = {5},
  pages = {70-79},
  doi = {10.11648/j.ijcems.20190505.13},
  url = {https://doi.org/10.11648/j.ijcems.20190505.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20190505.13},
  abstract = {A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3-fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of in-vitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.},
 year = {2019}
}

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TY  - JOUR
T1  - Correlation Between Immunological Laboratory Status of Omega-3-Fatty-Acid-Supplemented Patients of a German Fertility Centre and Outcome of IVF-Treatment
AU  - Arasch Bareksei
AU  - Gerd Hafner
AU  - Sebastian Pfeiffer
AU  - Kathrin Schlatterer
Y1  - 2019/10/17
PY  - 2019
N1  - https://doi.org/10.11648/j.ijcems.20190505.13
DO  - 10.11648/j.ijcems.20190505.13
T2  - International Journal of Clinical and Experimental Medical Sciences
JF  - International Journal of Clinical and Experimental Medical Sciences
JO  - International Journal of Clinical and Experimental Medical Sciences
SP  - 70
EP  - 79
PB  - Science Publishing Group
SN  - 2469-8032
UR  - https://doi.org/10.11648/j.ijcems.20190505.13
AB  - A well-defined group of patients of a German Fertility Centre, all supplemented periconceptually with omega-3-fatty acids, was monitored for specific alterations in the immunological laboratory status in correlation with the outcome of in-vitro-fertilization-(IVF)-treatment. For 36 of 52 IVF-patients IVF-treatment was successful. Patients with IVF-success revealed statistically significant lower soluble interleukin-2-receptor concentrations than unsuccessfully treated patients. Decreased numbers of CD4-positive T-cells could be correlated with increased failure rates of IVF, increased numbers of regulatory T-cells on the other hand with significantly improved success rates. Six of the parameters analyzed (T-lymphocytes, T-helper cells, B-lymphocytes, CD4/CD8 ratio and both classes of regulatory T-cells) significantly more often were below the median of the respective distribution in patients without IVF-success than in successfully treated. These results offer the possibility of developing a simple prognostic measure for the outcome of an IVF-therapy by assessing these parameters in relation to the median of the respective distribution. With increasing numbers of parameters lying below the median, the probability of successful IVF-treatment is decreasing.
VL  - 5
IS  - 5
ER  -

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