Case Series of Placental Mesenchymal Dysplasia with Live Birth
International Journal of Clinical and Experimental Medical Sciences
Volume 6, Issue 1, January 2020, Pages: 1-4
Received: Jun. 29, 2019;
Accepted: Dec. 23, 2019;
Published: Jan. 2, 2020
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Yanqing Kong, Department of Pathology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, China
Yanrui Zhang, Department of Pathology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, China
Hongping Tang, Department of Pathology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, China
Xueyu Chen, Department of Neonatology, Shenzhen Maternity and Child Healthcare Hospital, Southern Medical University, Shenzhen, China
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Objective: Placental mesenchymal dysplasia (PDM) is a rare disease, the cause is unknown, some are called mesenchymal stem hyperplasia, and some are called pseudo-vesicular block or vascular malformation. The aim is to report the clinical and pathologic characteristics of three cases of placental mesenchymal dysplasia (PMD). Method: Pathologic and clinical data were retrieved from the electronic medical records. The data were reviewed and summarized by the same pathologist. Results: Maternal age was respective 36 years, 31 years and 33 years. Cesarean section was performed at 39 weeks, 37 weeks and 38 weeks, respectively. The newborns were born with birth weight of 1790, 2370 and 3150 grams, respectively, with placenta weight of 590, 579 and 510 grams respectively. Placenta for pathological examination was performed macroscopically thick-walled vessels. Microscopic observation showed that the part of the stem villus was saclikely dilated, the blood vessels were thickened in the villi, the blood vessel wall was thickened, the villus interstitial was loose, and the mucus was changed. Part of the villus edema and degeneration, no trophoblastic hyperplasia, the final villus structure is normal. Conclusion: The size of the lesions in the Placental mesenchymal dysplasia and the location of the lesion is closely related to the birth weight of the newborn. Detailed histology is necessary for diagnosis and differential diagnosis.
Placental Developmental Abnormality, Placental Disease, Vascular Disease, Hydatidiform Mole
To cite this article
Case Series of Placental Mesenchymal Dysplasia with Live Birth, International Journal of Clinical and Experimental Medical Sciences. Special Issue: Pathology.
Vol. 6, No. 1,
2020, pp. 1-4.
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
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Tortoledo M, Galindo A, Ibarrola C. placental mesenchymal dysplasia associated with hepatic mesenchymal hamartoma and pulmonary hamartoma [J]. fetal pediatric pathology, 2010, 29 (4): 261-270.
Arizawa M. Nakayama M. Suspected involvement of the X chromosome in placental mesenchymal dysplasia [J]. Congenital Anomalies, 2002, 42 (4): 309-317.
Nayeri UA, West AB, Grossetta Nardini HK, Copel JA, Sfakianaki AK. Systematic review of sonographic findings of placental mesenchymal dysplasia and subsequent pregnancy outcome. Ultrasound Obstet Gynecol. 2013; 41: 366-74.
Gibson BR, Muir-Padilla J, Champeaux A, Suarez ES. Mesenchymal dysplasia of the placenta. Placenta. 2004; 25: 671-2.
Havva Serap Toru, Esra cobankent Aytekin, Cem Yasar Sanhal et al. We can Diagnose it if we Consider it. Diagnostic Pitfall for Placenta: Placental Mesenchymal Dysplasia [J]. Turkish J Path, 2015, 01310, 1-5.
Subrata P, Kingshuk B, Prabhat C M, et al. Placental Mesenchymal Dysplasia With Normal Fetus: A Rare Case Report [J]. Iran J Pathol. 2017; 12 (3): 307-310.
Chen CE, Chern SR, Wang TY, et al. Pregnancy with concomitant choragioma and placental vascular malformation with mesenchymal hyperplasia [J]. Hum Reprot, 1997, 12 (11), 2553-2556.
Takahashi H, Matsubara S, Kuwata T, et al. Changes in expression of vascular endothelial growth factor D-related genes in placental mesenchymal dysplasia [J]. J Obstet Gynaecol Res. 2014, 40 (4): 1145-9.
Ping AJ, Reeve AE, Law DJ, et al. Genetic linkage of Beckwith-Wiedemann syndrome to 11p15 [J]. Am J Hum Genet, 1989, 44 (5): 720-723.
Cohen M, Roper E, Sebire NJ, et al. Placental mesenchymal dysplasia associated with fetal aneuploidy [J]. Prenat Diag, 2005, 25 (3): 187—192.
Bogdan D, Sabina N V, Gabriela S, et al. A case report of placental mesenchymal dysplasia [J]. Medicine (2019) 98: 8 (e14554).
Parveen Z, Tongson-Ignacio JE, Fraser CR, et al. Placental mesenchymal dysplasia [J]. Arch Pathol Lab Med, 2007, 131 (1): 131-137.
Pham T, Steele J, Stayboldt C, et al. Placental mesenchymal dysplasia is associated with high rates of intrauterine growth restriction and fetal demise a Report of 11 new cases and a review of the literature. [J]. Am J Clin Pathol, 2006, 126 (1): 67-78.
Moscoso G, Jauniaux E, Hustin J. Placental vascular anomaly with diffuse mesenchymal stem villous hyperplasia: A new clinicopathological entity [J], Pathol Res Pract, 1991, 187 (23), 324-328.
Cai Wang, Wang Haili. TORCH effect of infection on human placental trophoblast and its mechanism [J]. M C Heal care C, 2016, 10 (31): 2180-2183.