Analysis of Status and Risk Factors for Macrovascular Complications in Type 2 Diabetes Mellitus
International Journal of Clinical and Experimental Medical Sciences
Volume 4, Issue 3, May 2018, Pages: 39-45
Received: Jun. 9, 2018; Accepted: Jun. 26, 2018; Published: Aug. 24, 2018
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Authors
Rui Han, Department of Diabetes, the First Affliated Hospital of Kunming Medical University, Kunming, China
Wei Yang, Department of Diabetes, the First Affliated Hospital of Kunming Medical University, Kunming, China
Dan Yang, Department of Diabetes, the First Affliated Hospital of Kunming Medical University, Kunming, China
Xia Dong, Department of Diabetes, the First Affliated Hospital of Kunming Medical University, Kunming, China
Lin Song, Department of Diabetes, the First Affliated Hospital of Kunming Medical University, Kunming, China
Hua Liu, Department of Diabetes, the First Affliated Hospital of Kunming Medical University, Kunming, China
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Abstract
The status and risk factors for atherosclerosis (AS) were investigated and the sensitivity and accuracy of existing examine methods of AS were evaluated in patients with diabetes mellitus(T2DM). Ninety nine patients who diagnosed with the WHO 1999 criteria for T2DM were enrolled in this study, which were divided into atherosclerotic group(group A) and non-atherosclerosis group(group B). The clinical characteristics, including fasting plasma glucose(FPG), postprandial plasma glucose(PPG), total cholesterol(TC), triglyceride(TG), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol(LDL-C), glycosylated hemoglobin A1c(HbAlc) and early examination methods of AS, including carotid intima-media thickness(CIMT), ankle brachial index(ABI) and pulse wave velocity (PWV) were recorded. The t-test, χ2 test or linear regression model were used for retrospective analyses then showed that the prevalence rate of carotid plaque was 29.3%( 29/99), there is no difference between the distribution of age and gender in the group with or without plaque (χ2 = 0.044, P>0.05; t = 0.850, P>0.05). It also demonstrated that systolic blood pressure(SBP), diastolic blood pressure (DBP), LDL-C, CIMT, history of smoke were significantly higher in plaques group than that of without plaques ( P<0.05). Logistic analysis showed that LDL-C and CIMT were independent risk factors for incidence of cervical atheromatous plaques in type 2 diabetic patients (P<0.05). The risk of AS has increased by 1.7 times by every unit of LDL-C, as well as increased by 13.8 times by every unit of CIMT. CIMT and PWV, but not ABI, are valuable for AS diagnosing. According to sensitivity and specificity, the best diagnostic value for CIMT is 0.9mm and for PWV is 1560.As a result, LDL-C and CIMT are independent risk factors for AS. Early intervention and controlling of risks factors will have clinical value for prevention and treatment of macrovascular diseases in T2DM. The corresponding cut-off points 1560 of PWV is better than 1400 for diagnosis of AS in this hospital.
Keywords
T2DM, Atherosclerosis, CIMT, ABI, PWV
To cite this article
Rui Han, Wei Yang, Dan Yang, Xia Dong, Lin Song, Hua Liu, Analysis of Status and Risk Factors for Macrovascular Complications in Type 2 Diabetes Mellitus, International Journal of Clinical and Experimental Medical Sciences. Vol. 4, No. 3, 2018, pp. 39-45. doi: 10.11648/j.ijcems.20180403.13
Copyright
Copyright © 2018 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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