International Journal of Clinical and Experimental Medical Sciences

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Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis

Received: 14 April 2018    Accepted: 02 May 2018    Published: 19 May 2018
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Abstract

Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects many extrahepatic-organ systems. In this respect, several studies have suggested the possible association between NAFLD and the risk of incident chronic kidney disease (CKD). However, the extent of this association remains unclear. Thus the present meta-analysis was conducted to better characterize this association. In the meta-analysis, a comprehensive search of the databases of MEDLINE, EMBASE, Web of Science and Cochran Library was carried out from inception through September 2017. All large observational studies that investigated the association between NAFLD and the risk of incident CKD were included. The incident CKD was defined as occurrence of estimated glomerular filtration rate (eGFR) < 60ml/min/1.73m2 and/or overt proteinuria. The pooled hazard ratio (HR) with 95% confidence intervals (CIs) was calculated using the random-effects model. Data were extracted from 5 large observational studies involving 57,341 adult individuals (41.3% with NAFLD) with 1,886 cases of incident CKD. NAFLD is significantly associated with increased risk of incident CKD (HR 1.40, 95%CI 1.22-1.61). The statistical heterogeneity of included studies was low, with an I2=25.4%. In conclusion, the present meta-analysis confirms the association between NAFLD and the risk of incident CKD.

DOI 10.11648/j.ijcems.20180402.12
Published in International Journal of Clinical and Experimental Medical Sciences (Volume 4, Issue 2, March 2018)
Page(s) 26-31
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Nonalcoholic Fatty Liver, Chronic Kidney Disease, Meta-Analysis

References
[1] Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011; 34:274-285.
[2] Younossi ZM, Stepanova M, Afendy M, Fang Y, Younossi Y, Mir H, et al. Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol 2011; 9:524.e1–530.e1.
[3] Byrne CD, Targher G. NAFLD: a multisystem disease. J Hepatol 2015; 62 (Suppl):S47–S64.
[4] Adams LA, Anstee QM, Tilg H, Targher G. Non-alcoholic fatty liver disease and its relationship with cardiovascular disease and other extrahepatic diseases. Gut 2017; 66:1138-1153.
[5] Targher G, Chonchol MB, Byrne CD. CKD and nonalcoholic fatty liver disease. Am J Kidney Dis 2014; 64:638-652.
[6] Targher G, Byrne CD. Non-alcoholic fatty liver disease: an emerging driving force in chronic kidney disease. Nat Rev Nephrol 2017; 13:297-310.
[7] Petersen MC, Shulman GI. Roles of diacylglycerols and ceramides in hepatic insulin resistance. Trends Pharmacol Sci 2017; 38:649-665.
[8] Meex RCR, Watt MJ. Hepatokines: linking nonalcoholic fatty liver disease and insulin resistance. Nat Rev Endocrinol 2017; 13:509-520.
[9] Francque SM, van der Graaff D, Kwanten WJ. Non-alcoholic fatty liver disease and cardiovascular risk: pathophysiological mechanisms and implications. J Hepatol 2016; 65:425-443.
[10] Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group. Jama 2000; 283:2008–2012.
[11] Stang A. Critical evaluation of the Newcastle–Ottawa scale for the assessment of the quality of nonrandomized studies in meta-analyses. Eur J Epidemiol 2010; 25:603–605.
[12] Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ 2003; 327:557–560.
[13] Chang Y, Ryu S, Sung E, Woo HY, Oh E, Cha K, et al. Nonalcoholic fatty liver disease predicts chronic kidney disease in nonhypertensive and nondiabetic Korean men. Metabolism 2008; 57:569-576.
[14] Targher G, Chonchol M, Bertolini L, Rodella S, Zenari L, Lippi G, et al. Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease. J Am Soc Nephrol 2008; 19:1564-1570.
[15] Arase Y, Suzuki F, Kobayashi M, Suzuki Y, Kawamura Y, Matsumoto N, et al. The development of chronic kidney disease in Japanese patients with non-alcoholic fatty liver disease. Intern Med 2011; 50:1081-1087.
[16] Targher G, Mantovani A, Pichiri I, Mingolla L, Cavalieri V, Mantovani W, et al. Nonalcoholic fatty liver disease is independently associated with an increased incidence of chronic kidney disease in patients with type 1 diabetes. Diabetes Care 2014; 37:1729-1736.
[17] Sinn DH, Kang D, Jang HR, Gu S, Cho SJ, Paik SW, et al. Nonalcoholic fatty liver disease and development of chronic kidney disease: a retrospective cohort study. J Hepatol 2017; 66 (Suppl): S155.
[18] Huh JH, Kim JY, Choi E, Kim JS, Chang Y, Sung KC. The fatty liver index as a predictor of incident chronic kidney disease in a 10-year prospective cohort study. PLoS One 2017; 12:e0180951.
[19] Musso G, Gambino R, Tabibian JH, Ekstedt M, Kechagias S, Hamaguchi M, et al. Association of non-alcoholic fatty liver disease with chronic kidney disease: a systematic review and meta-analysis. PLoS Med 2014; 11:e1001680.
[20] Colicchio P, Tarantino G, del Genio F, Sorrentino P, Saldalamacchia G, Finelli C, et al. Non-alcoholic fatty liver disease in young adult severely obese non-diabetic patients in South Italy. Ann Nutr Metab 2005; 49:289-295.
[21] Leite NC, Salles GF, Araujo AL, Villela-Nogueira CA, Cardoso CR. Prevalence and associated factors of non-alcoholic fatty liver disease in patients with type-2 diabetes mellitus. Liver Int 2009; 29:113-119.
[22] Assy N, Kaita K, Mymin D, Levy C, Rosser B, Minuk G. Fatty infiltration of liver in hyperlipidemic patients. Dig Dis Sci 2000; 45:1929-34.
[23] Gaggini M, Morelli M, Buzzigoli E, DeFronzo RA, Bugianesi E, Gastaldelli A. Non-alcoholic fatty liver disease (NAFLD) and its connection with insulin resistance, dyslipidemia, atherosclerosis and coronary heart disease. Nutrients 2013; 5:1544-60.
[24] European Association for the Study of the Liver (EASL), European Association for the Study of Diabetes (EASD), European Association for the Study of Obesity (EASO). EASL-EASD-EASO Clinical Practice Guidelines for the management of non-alcoholic fatty liver disease. J Hepatol 2016; 64:1388-1402.
[25] Lee SS, Park SH. Radiologic evaluation of nonalcoholic fatty liver disease. World J Gastroenterol 2014; 20:7392–7402.
[26] Shi KQ, Tang JZ, Zhu XL, Ying L, Li DW, Gao J, et al. Controlled attenuation parameter for the detection of steatosis severity in chronic liver disease: a meta-analysis of diagnostic accuracy. J Gastroenterol Hepatol 2014; 29:1149-58.
Author Information
  • Department of Gastroenterology, Zhangzhou Municipal Hospital of Fujian Medical University, Zhangzhou, China

  • Department of Hemodialysis, Zhangzhou Municipal Hospital of Fujian Medical University, Zhangzhou, China

  • Department of Gastroenterology, Zhangzhou Municipal Hospital of Fujian Medical University, Zhangzhou, China

  • Department of Gastroenterology, Zhangzhou Municipal Hospital of Fujian Medical University, Zhangzhou, China

  • Department of Internal Medicine, Zhangzhou Municipal Hospital of Fujian Medical University, Zhangzhou, China

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    Yichao Zheng, Yifen Wu, Yadong Lai, Hanxu Zhuang, Guian Zheng. (2018). Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis. International Journal of Clinical and Experimental Medical Sciences, 4(2), 26-31. https://doi.org/10.11648/j.ijcems.20180402.12

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    ACS Style

    Yichao Zheng; Yifen Wu; Yadong Lai; Hanxu Zhuang; Guian Zheng. Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis. Int. J. Clin. Exp. Med. Sci. 2018, 4(2), 26-31. doi: 10.11648/j.ijcems.20180402.12

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    AMA Style

    Yichao Zheng, Yifen Wu, Yadong Lai, Hanxu Zhuang, Guian Zheng. Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis. Int J Clin Exp Med Sci. 2018;4(2):26-31. doi: 10.11648/j.ijcems.20180402.12

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  • @article{10.11648/j.ijcems.20180402.12,
      author = {Yichao Zheng and Yifen Wu and Yadong Lai and Hanxu Zhuang and Guian Zheng},
      title = {Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {4},
      number = {2},
      pages = {26-31},
      doi = {10.11648/j.ijcems.20180402.12},
      url = {https://doi.org/10.11648/j.ijcems.20180402.12},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijcems.20180402.12},
      abstract = {Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects many extrahepatic-organ systems. In this respect, several studies have suggested the possible association between NAFLD and the risk of incident chronic kidney disease (CKD). However, the extent of this association remains unclear. Thus the present meta-analysis was conducted to better characterize this association. In the meta-analysis, a comprehensive search of the databases of MEDLINE, EMBASE, Web of Science and Cochran Library was carried out from inception through September 2017. All large observational studies that investigated the association between NAFLD and the risk of incident CKD were included. The incident CKD was defined as occurrence of estimated glomerular filtration rate (eGFR) 2 and/or overt proteinuria. The pooled hazard ratio (HR) with 95% confidence intervals (CIs) was calculated using the random-effects model. Data were extracted from 5 large observational studies involving 57,341 adult individuals (41.3% with NAFLD) with 1,886 cases of incident CKD. NAFLD is significantly associated with increased risk of incident CKD (HR 1.40, 95%CI 1.22-1.61). The statistical heterogeneity of included studies was low, with an I2=25.4%. In conclusion, the present meta-analysis confirms the association between NAFLD and the risk of incident CKD.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Nonalcoholic Fatty Liver Disease and the Risk of Incident Chronic Kidney Disease: A Meta-Analysis
    AU  - Yichao Zheng
    AU  - Yifen Wu
    AU  - Yadong Lai
    AU  - Hanxu Zhuang
    AU  - Guian Zheng
    Y1  - 2018/05/19
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    N1  - https://doi.org/10.11648/j.ijcems.20180402.12
    DO  - 10.11648/j.ijcems.20180402.12
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 26
    EP  - 31
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20180402.12
    AB  - Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects many extrahepatic-organ systems. In this respect, several studies have suggested the possible association between NAFLD and the risk of incident chronic kidney disease (CKD). However, the extent of this association remains unclear. Thus the present meta-analysis was conducted to better characterize this association. In the meta-analysis, a comprehensive search of the databases of MEDLINE, EMBASE, Web of Science and Cochran Library was carried out from inception through September 2017. All large observational studies that investigated the association between NAFLD and the risk of incident CKD were included. The incident CKD was defined as occurrence of estimated glomerular filtration rate (eGFR) 2 and/or overt proteinuria. The pooled hazard ratio (HR) with 95% confidence intervals (CIs) was calculated using the random-effects model. Data were extracted from 5 large observational studies involving 57,341 adult individuals (41.3% with NAFLD) with 1,886 cases of incident CKD. NAFLD is significantly associated with increased risk of incident CKD (HR 1.40, 95%CI 1.22-1.61). The statistical heterogeneity of included studies was low, with an I2=25.4%. In conclusion, the present meta-analysis confirms the association between NAFLD and the risk of incident CKD.
    VL  - 4
    IS  - 2
    ER  - 

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