Urinary schistosomiasis is caused by Schistosoma heamatobium worm and it is most common source of haematuria (blood in urine) worldwide. This disease has long been recognized as serious public health to man especially in countries like Nigeria, Egypt, with currently more than 790 million people at risk. Since IL-4 stimulates IgE production, the hypothesis that Helper T cell 2 (Th2) associated with cell immunity participate in protection to reinfection in an anti-inflammatory dichotomy manner. IL-4 confers proliferation of T cells, induction of class switching immunoglobulins and also serve as a biomarker in co association with IL-5 for (Th2). The aim of this review paper is to simplify the immunological mechanism that happens when Schistosome worm elicit strong humoral and cellular response in definite host.
| Published in | International Journal of Clinical and Experimental Medical Sciences (Volume 3, Issue 5) |
| DOI | 10.11648/j.ijcems.20170305.11 |
| Page(s) | 57-60 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
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Copyright © The Author(s), 2024. Published by Science Publishing Group |
Helper T Cell, Schistosomiasis, Interleukin 4, Immunoglobulin
| [1] | Nmorsi, O. P. G. (2009). Principles of Parasitology. PON Publication, 100-107. |
| [2] | Abdulkadir, A., Ahmed, M., Abubakar, B. M., Suleiman, I. E., Yusuf, I., Imam, I. M., and Musa, B. M. (2017). Prevalence of Urinary schistosomiasis in Nigeria Systematic Review and Meta-analysis. African Journal of Urology, 1994–2015. |
| [3] | Gryseels, B., Polman, K., Clerinx, J. and Kestens, L. (2006). Human schistosomiasis. The Lancet, 368(9541), 1106-1118. |
| [4] | Colley, D. G., Bustinduy, A. L., Secor, W. E. and King, C. H. (2014). Human schistosomiasis. The Lancet, 383(9936), 2253-2264. |
| [5] | Steinmann, P., Keiser, J., Bos, R., Tanner, M. and Utzinger, J. (2006). Schistosomiasis and Water Resources Development: Systematic Review, Meta-analysis, and Estimates of People at Risk. The Lancet infectious diseases, 6(7), 411-425. |
| [6] | Mueller, T. D., Zhang, J. L., Sebald, W., and Duschl, A. (2002). Structure, Binding, and Antagonists in the IL-4/IL-13 Receptor System. Biochimica et Biophysica Acta (BBA)Molecular Cell Research, 1592(3), 237-250. |
| [7] | Paul, W. E. (2015). History of interleukin-4. Cytokine, 75(1), 3-7. |
| [8] | Guo, L., Urban, J. F., Zhu, J. and Paul, W. E. (2008). Elevating Calcium in Th2 Cells Activates Multiple Pathways to Induce IL-4 Transcription and mRNA Stabilization. Journal of Immunology.181:3984–3993. |
| [9] | Price, A. E., Liang, H. E., Sullivan, B. M., Reinhardt, R. L., Eisley, C. J., Erle, D. J., and Locksley, R. M. (2010). Systemically Dispersed Innate IL-13-expressing Cells in Type 2 Immunity. Proceedings of the National Academy of Sciences,107:11489–11494. |
| [10] | Zhu, Y. C. (2005). Immunodiagnosis and its Role in Schistosomiasis Control in China: a Review. Actatropica, 96(2), 130-136. |
| [11] | Hosoyama, T., Aslam, M. I., Abraham, J., Prajapati, S. I., Nishijo, K., Michalek, J. E. and Keller, C. (2011). IL-4R drives dedifferentiation, mitogenesis, and metastasis in rhabdomyosarcoma. Clinical Cancer Research, 17(9), 2757-2766. |
| [12] | Bhattarai, P., Thomas, A. K., Cosacak, M. I., Papadimitriou, C., Mashkaryan, V., Froc, C. and Kizil, C. (2016). IL4/STAT6 signaling activates neural stem cell proliferation and neurogenesis upon Amyloid-β42 aggregation in adult zebrafish brain. Cell reports, 17(4), 941-948. |
| [13] | Nester, A., Roberts, P., Pearsall, N. N. and Anderson, D. G. (2009). Microbiology: A Human Perspective, eight edition, Mc Graw Hill Education. |
| [14] | Arinola, O. G. (2005). Immunological Aspects of Urinary Schistosomiasis in Ibadan, Southwestern Nigeria. Journal of the Association of Resident Doctors, 3(1), 5. |
| [15] | de Morais, C. G. V., Castro Lima, A. K., Terra, R., dos Santos, R. F., Da-Silva, S. A. G. and Dutra, P. M. L. (2015). The dialogue of the host-parasite relationship: Leishmania spp. and Trypanosoma cruzi infection. Bio Medical research international, 2015. |
| [16] | Janeway, C. A., Travers, P., Walport, M. and Shlomchik, M. (2001). Immunology. New York: Garland Science. |
| [17] | Colley, D. G., and Secor, W. E. (2014). Immunology of Human schistosomiasis. Parasite Immunology, 36(8), 347-357. |
| [18] | Jung, Y. and Rothenberg, M. E. (2014). Roles and Regulation of Gastrointestinal Eosinophils in Immunity and Disease. The Journal of Immunology, 193(3), 999-1005. |
| [19] | Nmorsi, O. P. G., Ukw, N. C. D., Isaac, C., Egwunyenga, A. O. and Olague, N. H. (2007). Immunoglobulin Profile of some Nigerians with Schistosoma haematobiu Infection. African Journal of Microbiology Research, 1(7), 113-116. |
| [20] | Elfaki, T. E. M., Arndts, K., Wiszniewsky, A., Ritter, M., Goreish, I. A., Misk El Yemen, A. and Hoerauf, A. (2016). Multivariable Regression Analysis in Schistosomamansoni-Infected Individuals in the Sudan Reveals Unique Immunoepid emiological Profiles in Uninfected, Egg+ and non-egg+ infected Individuals. PLOS Neglected Tropical Disease, 10(5). |
| [21] | Kardoush, M. I. (2016). Identification of Candidate Serum Biomarkers for Schistosomiasis Infection using Mass Spectrometric Approaches (Doctoral dissertation, McGill University) 20-23. |
| [22] | Murphy, K. and Weaver, C. (2016). Janeway's immunobiology. Garland Science. 48-64. |
| [23] | Wagner, B. (2016). Immunoglobulin E and allergy. Equine veterinary journal, 48(1), 13-14. |
| [24] | Fitzsimmons, C. M., Falcone, F. H., and Dunne, D. W. (2014). Helminth Allergens, Parasite-specific IgE and its Protective Role in Human Immunity. Frontiers in Immunology, 47-65. |
| [25] | Douglas, S. D. (2016). Introduction. In Manual of Molecular and Clinical Laboratory Immunology, Eighth Edition. 259-262. |
APA Style
Aigbogun Edwin Ighodaro, Mohammed Sani Sambo Datsugwai, Umar Nabeela Bello, Afangide Christopher Stephen. (2017). Interleukin 4 (IL-4) in Urinary Schistosomiasis as a Diagnostic Biomarker During Its Reinfection- A Review. International Journal of Clinical and Experimental Medical Sciences, 3(5), 57-60. https://doi.org/10.11648/j.ijcems.20170305.11
ACS Style
Aigbogun Edwin Ighodaro; Mohammed Sani Sambo Datsugwai; Umar Nabeela Bello; Afangide Christopher Stephen. Interleukin 4 (IL-4) in Urinary Schistosomiasis as a Diagnostic Biomarker During Its Reinfection- A Review. Int. J. Clin. Exp. Med. Sci. 2017, 3(5), 57-60. doi: 10.11648/j.ijcems.20170305.11
AMA Style
Aigbogun Edwin Ighodaro, Mohammed Sani Sambo Datsugwai, Umar Nabeela Bello, Afangide Christopher Stephen. Interleukin 4 (IL-4) in Urinary Schistosomiasis as a Diagnostic Biomarker During Its Reinfection- A Review. Int J Clin Exp Med Sci. 2017;3(5):57-60. doi: 10.11648/j.ijcems.20170305.11
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Download@article{10.11648/j.ijcems.20170305.11,
author = {Aigbogun Edwin Ighodaro and Mohammed Sani Sambo Datsugwai and Umar Nabeela Bello and Afangide Christopher Stephen},
title = {Interleukin 4 (IL-4) in Urinary Schistosomiasis as a Diagnostic Biomarker During Its Reinfection- A Review},
journal = {International Journal of Clinical and Experimental Medical Sciences},
volume = {3},
number = {5},
pages = {57-60},
doi = {10.11648/j.ijcems.20170305.11},
url = {https://doi.org/10.11648/j.ijcems.20170305.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20170305.11},
abstract = {Urinary schistosomiasis is caused by Schistosoma heamatobium worm and it is most common source of haematuria (blood in urine) worldwide. This disease has long been recognized as serious public health to man especially in countries like Nigeria, Egypt, with currently more than 790 million people at risk. Since IL-4 stimulates IgE production, the hypothesis that Helper T cell 2 (Th2) associated with cell immunity participate in protection to reinfection in an anti-inflammatory dichotomy manner. IL-4 confers proliferation of T cells, induction of class switching immunoglobulins and also serve as a biomarker in co association with IL-5 for (Th2). The aim of this review paper is to simplify the immunological mechanism that happens when Schistosome worm elicit strong humoral and cellular response in definite host.},
year = {2017}
}
TY - JOUR T1 - Interleukin 4 (IL-4) in Urinary Schistosomiasis as a Diagnostic Biomarker During Its Reinfection- A Review AU - Aigbogun Edwin Ighodaro AU - Mohammed Sani Sambo Datsugwai AU - Umar Nabeela Bello AU - Afangide Christopher Stephen Y1 - 2017/10/10 PY - 2017 N1 - https://doi.org/10.11648/j.ijcems.20170305.11 DO - 10.11648/j.ijcems.20170305.11 T2 - International Journal of Clinical and Experimental Medical Sciences JF - International Journal of Clinical and Experimental Medical Sciences JO - International Journal of Clinical and Experimental Medical Sciences SP - 57 EP - 60 PB - Science Publishing Group SN - 2469-8032 UR - https://doi.org/10.11648/j.ijcems.20170305.11 AB - Urinary schistosomiasis is caused by Schistosoma heamatobium worm and it is most common source of haematuria (blood in urine) worldwide. This disease has long been recognized as serious public health to man especially in countries like Nigeria, Egypt, with currently more than 790 million people at risk. Since IL-4 stimulates IgE production, the hypothesis that Helper T cell 2 (Th2) associated with cell immunity participate in protection to reinfection in an anti-inflammatory dichotomy manner. IL-4 confers proliferation of T cells, induction of class switching immunoglobulins and also serve as a biomarker in co association with IL-5 for (Th2). The aim of this review paper is to simplify the immunological mechanism that happens when Schistosome worm elicit strong humoral and cellular response in definite host. VL - 3 IS - 5 ER -
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