| Peer-Reviewed

Biomodulators of Anxiety

Received: 17 December 2015    Accepted: 7 January 2016    Published: 19 February 2016
Views:       Downloads:
Abstract

Anxiety is a feeling of unease which everyone feels at some points in their lives. Anxiety becomes a disorder when the symptoms become chronic and interfere daily lives, including behavioral patterns and adaptations. Anxiety disorders come in many forms - Generalized Anxiety Disorder, Panic and Post-traumatic Stress disorders, Obsessive Compulsive Disorders, Social Anxiety Disorders and various Phobias. The state of anxiety is modulated by a multifarious and complex series of biomodulators of the categories, neurotransmitters, peptides and hormones comprising serotonin, norepinephrine, Gamma-Aminobutyric acid (GABA), cortisol, Corticotropin Releasing Factor (CRF), Acetylcholine and many more. The article reviews the anxiogenic and/or anxiolytic functions of selected biomodulators in maintaining anxiety related behaviours.

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 2, Issue 1)
DOI 10.11648/j.ijcems.20160201.12
Page(s) 7-12
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Anxiety, GABA, Serotonin, Norepinephrine, HPA Axis

References
[1] Ninan P T. Dissolving the burden of generalized anxiety disorder. J Clin Psychiatry. 2001; 62.
[2] Higgins E S and Gorge M S. The neuroscience of clinical psychiatry: The pathophysiology behaviour and mental illness. 1st edition. 2007.
[3] Rachman S. Clinical Psychology: Anxiety. 1998.
[4] Etkin A. Functional neuroanatomy of anxiety: a neural circuit perspective. Curr Top Behav Neurosci. 2010; 251-277.
[5] Kessler R C, McGonagle K A, Zhao S, et al. Lifetime and 12-month prevalence of DSM-III-R psychiatric disorders in the United States: Results from the National Comorbidity Survey. Arch Gen Psychiatry 1994; 8-19.
[6] Gilhotra N and Dhingra D. Neurochemical modulation of anxiety disorders. International Journal of Pharmacy and Pharmaceutical Sciences. 2010; 1-6.
[7] Ishikawa R, Kobori O and Shimizu E. Development and validation of the Japanese version of the obsessive-compulsive inventory. BMC Res Notes. 2014; 306.
[8] Fricchione G. Generalized anxiety Disorder. N Engl J Med. 2004; 675-682.
[9] American Psychiatric Association. Diagnostic and statistical manual of mental disorders (Fifth edition). Washington, D.C.: American Psychiatric Association; 2013.
[10] Creighton A S, Davison T E and Kissane D W. The prevalence of anxiety among older adults in nursing homes and other aged care facilities: a systematic review. Int J Geriatr Psychiatry. 2015; doi: 10.1002/gps.4378.
[11] Kang H J, Yoon S and Lyoo I K. Peripheral Biomarker candidates of posttraumatic stress disorder. Exp Neurobiol. 2015; 186-196.
[12] Schneier F R. Social Anxiety Disorder. N Engl J Med. 2006; 1029-1036.
[13] Bourne and Edmund J. The anxiety and phobia workbook (5th ed.) New harbinger Publications. 2011; 50-51.
[14] Young E A, Abelson J L and Cameron O G. Effect of co-morbid anxiety disorders on the hypothalamic-pituitary-adrenal axis response to a social stressor in major depression. Biol Psychiatry. 2004; 113-120.
[15] Rose L E, McLean L M. Anxiety disorders during pregnancy and the postpartum period. J Clin Psychiatry. 2006; 1285-1298.
[16] Gladstone G L, Parker G B, Malhi G S. Do bullied children become anxious and depressed adults?: A cross-sectional investigation of the correlates of bullying and anxious depression. J Nerv Ment Dis. 2006; 201-208.
[17] Gamez W, Watson D, Doebbeling B N. Abnormality personality and the mood and anxiety disorders: Implications for structural models of anxiety and depression. J Anxiety Disord. 2007; 526-539.
[18] Karatzias A. Chouliara Z, Power K and Swanson V. Predicting general well-being from self-esteem and affectivity: An extrapolatory study with Scottish adolescents. Qual Life Res. 2006; 1143-1151.
[19] Steimer T. The biology of fear and anxiety-related behaviours. Dialogues Clin neurosci. 2002; 231-249.
[20] Deepak M, Alok T S, Paresh W J, Abhijit S V and Anil CV. Neurobilogical modulators of anxiety. International Research Journal of Pharmacy. 2012; 60-64.
[21] Bannerman DM, Rawlins JN, McHugh SB, et al. Regional dissociations within the hippocampus – memory and anxiety. Neurosci Biobehav Rev. 2004; 273–283.
[22] Tanaka M, Yoshida M, Emoto H, Ishii H. Noradrenaline systems in the hypothalamus, amygdala and locus coeruleus are involved in the provo- cation of anxiety: basic studies. Eur J Pharmacol. 2000; 397-406.
[23] Geracioti T D. CSF norepinephrine concentrations in post-traumatic stress disorder. Am J Psychiatry. 2001; 1227-1230.
[24] Kao C Y, Stalla G, Stalla J, Wotjak CT, Anderzhanova E. Norepinephrine and corticosterone in the medial prefrontal cortex and hippocampus predict PTSD/like symptoms in mice. Eur J Neurosci. 2015; 1139-1148.
[25] Lin S H, Lee L T and Yang Y K. Serotonin and mental disorders: a concise review on molecular neuroimaging evidence. Clin Psychopharmacol Neurosci. 2014; 196-202.
[26] Marchesi C, Ossola P, Amerio A, Daniel B D, Tonna M, De Panfilis C. Clinical management of perinatal anxiety disorders: A systematic review. J Affect Disord. 2015; 543-550.
[27] Lanzenberger RR, Mitterhauser M, Spindelegger C, et al. Reduced serotonin-1A receptor binding in social anxiety disorder. Biol Psychiatry. 2007; 1081-1089.
[28] Van der Wee N J, van Veen J F, Stevens H, van Vliet I M, van Rijk p P and Westenberg H G. Increased serotonin and dopamine transporter binding in psychotropic medication naive patients with generalized social anxiety disorder shown by 123I-beta-(4-iodophenyl)-tropane SPECT. J Nucl Med. 2008; 757-763.
[29] Nuss P. Anxiety disorders and GABA neurotransmission: a disturbance of modulation. Neuropsychiatr Dis Treat. 2015; 165-175.
[30] Mantella RC, Butters MA, Amico JA, et al. Salivary cortisol is associated with diagnosis and severity of late-life generalized anxiety disorder. Psychoneuroendocrinology. 2008; 773–781.
[31] Lenze EJ, Mantella RC, Shi P, et al. Elevated cortisol in older adults with Generalized Anxiety Disorder is reduced by treatment: a placebo-controlled evaluation of escitalopram. Am J Geriatr Psychiatry. 2011; 482-490.
[32] Magin G N, Heinrichs S C and Dunn A J. The role of CRH in behavioral responses to stress. Peptides. 2001; 713-724.
[33] Victoria B R and Murray B S. Role of Corticotropin Releasing Factor in anxiety disorders: A translational research perspective. Horm Behav. 2006; 550-561.
[34] Kutlu M G and Gould T J. N. Nicotine modulation of fear memories and anxiety: Implications for learning and anxiety disorders. Biochem Pharmacol. 2015; 498-511.
[35] Tresa M M, Natalie E P, Sharon R G, Stephen E H and Booker T K. 42 Nicotinic acetylcholine receptors on dopaminergic neurones mediate nicotine reward and anxiety relief. J. Neurosci. 2011; 10891-10902.
[36] Koopmann A, Lemenager T, Wolf N D, et al. The impact of atrial natriuretic peptide on anxiety, stress and craving in patients with alcohol dependence. Alcohol and Alcoholism. 2013; 282-286.
[37] Rotzinger S and Vaccarino F J. Cholecystokinin receptor subtypes:role in the modulation of anxiety-related and reward-related behaviours in animal models. J Psychiatry Neurosci. 2003; 171-181.
[38] Moreira F A and Wotlak C T. Cannabinoids and anxiety. Curr Top Behav Neurosci. 2010; 429-450.
[39] Silk D B, Davis A, Vulevic J, Tzortzis G and Gibson G R. Clinical trial: The effects of a trans-galactooligosaccharide prebiotic on faecal microbiota and symptoms in irritable bowel syndrome. Aliment Pharmacol Ther. 2009; 508-518.
[40] Bravo J A, Forsythe P, Chew M V, et al. Ingestion of Lactobacillus strain regulates emotional bahaviour and central GABA receptor expression in an mouse via the vagus nerve. Proc Natl Acad Sci USA. 2011; 16050-16055.
[41] Bercik P, Park AJ, Sinclair D, et al. The anxiolytic effect of Bifidobacterium longum NCC 3001 involves vagal pathways for gut-brain communcation. Neurogastroenetrl Motil. 2011; 1132-1139.
[42] Desbonnet L, Garrett L, Clarke G, Kiely B, Cryan J F and Dinan T G. Effets of the probiotic Bifidobacterium infantis in the maternal seperation model of depression. Neuroscience. 2010; 1179-1188.
[43] Buydens-Branchey L and Branchey M. n-3 polyunsaturated fatty acids decrease anxiety feelings in a population of substance abusers. J Clin Psychopharmacol. 2006; 661-665.
[44] de Sousa DP, Hocayen Pde A, Andrade LN, Andreatini R. A systematic review of the anxiolytic- like effects of essential oils in animal models. Molecules. 2015; 18620-18660.
[45] Yoga for the Treatment of Post-Traumatic Stress Disorder, Generalized Anxiety Disorder, Depression, and Substance Abuse: A Review of the Clinical Effectiveness and Guidelines [Internet]. Ottawa (ON): Canadian Agency for Drugs and Technologies in Health; 2015 Jun. CADTH Rapid Response Reports. Available from: http://www.ncbi.nlm.nih.gov/books/NBK304569/
Cite This Article
  • APA Style

    Preetham Elumalai, Sreeja Lakshmi. (2016). Biomodulators of Anxiety. International Journal of Clinical and Experimental Medical Sciences, 2(1), 7-12. https://doi.org/10.11648/j.ijcems.20160201.12

    Copy | Download

    ACS Style

    Preetham Elumalai; Sreeja Lakshmi. Biomodulators of Anxiety. Int. J. Clin. Exp. Med. Sci. 2016, 2(1), 7-12. doi: 10.11648/j.ijcems.20160201.12

    Copy | Download

    AMA Style

    Preetham Elumalai, Sreeja Lakshmi. Biomodulators of Anxiety. Int J Clin Exp Med Sci. 2016;2(1):7-12. doi: 10.11648/j.ijcems.20160201.12

    Copy | Download

  • @article{10.11648/j.ijcems.20160201.12,
      author = {Preetham Elumalai and Sreeja Lakshmi},
      title = {Biomodulators of Anxiety},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {2},
      number = {1},
      pages = {7-12},
      doi = {10.11648/j.ijcems.20160201.12},
      url = {https://doi.org/10.11648/j.ijcems.20160201.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20160201.12},
      abstract = {Anxiety is a feeling of unease which everyone feels at some points in their lives. Anxiety becomes a disorder when the symptoms become chronic and interfere daily lives, including behavioral patterns and adaptations. Anxiety disorders come in many forms - Generalized Anxiety Disorder, Panic and Post-traumatic Stress disorders, Obsessive Compulsive Disorders, Social Anxiety Disorders and various Phobias. The state of anxiety is modulated by a multifarious and complex series of biomodulators of the categories, neurotransmitters, peptides and hormones comprising serotonin, norepinephrine, Gamma-Aminobutyric acid (GABA), cortisol, Corticotropin Releasing Factor (CRF), Acetylcholine and many more. The article reviews the anxiogenic and/or anxiolytic functions of selected biomodulators in maintaining anxiety related behaviours.},
     year = {2016}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Biomodulators of Anxiety
    AU  - Preetham Elumalai
    AU  - Sreeja Lakshmi
    Y1  - 2016/02/19
    PY  - 2016
    N1  - https://doi.org/10.11648/j.ijcems.20160201.12
    DO  - 10.11648/j.ijcems.20160201.12
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 7
    EP  - 12
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20160201.12
    AB  - Anxiety is a feeling of unease which everyone feels at some points in their lives. Anxiety becomes a disorder when the symptoms become chronic and interfere daily lives, including behavioral patterns and adaptations. Anxiety disorders come in many forms - Generalized Anxiety Disorder, Panic and Post-traumatic Stress disorders, Obsessive Compulsive Disorders, Social Anxiety Disorders and various Phobias. The state of anxiety is modulated by a multifarious and complex series of biomodulators of the categories, neurotransmitters, peptides and hormones comprising serotonin, norepinephrine, Gamma-Aminobutyric acid (GABA), cortisol, Corticotropin Releasing Factor (CRF), Acetylcholine and many more. The article reviews the anxiogenic and/or anxiolytic functions of selected biomodulators in maintaining anxiety related behaviours.
    VL  - 2
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • School of Aquatic Food Products and Technology, Kerala University of Fisheries and Ocean Studies, Panangad, Kochi, Kerala, India

  • School of Aquatic Food Products and Technology, Kerala University of Fisheries and Ocean Studies, Panangad, Kochi, Kerala, India

  • Sections