| Peer-Reviewed

Hemodynamic Assessment Using Pressure-Volume (PV) During Mechanical Circulatory Support

Received: 17 October 2015    Accepted: 7 November 2015    Published: 3 December 2015
Views:       Downloads:
Abstract

Mechanical circulatory support devices (MCS), namely percutaneous ventricular assist devices (pVAD) are temporarily introduced to support circulation in hemodynamically compromised patients and also during mid to high risk coronary artery procedures. Their multiple responsibilities include maintaining an adequate systemic blood pressure and cardiac output to provide satisfactory end-organ perfusion in unloading of the failing ventricle, and to temporary lower myocardial contractility while reducing myocardial oxygen demand supporting favorable ventricular remodeling. To timely and quantitatively assess hemodynamics during pVAD circulatory support post-cardiogenic shock or acute myocardial infarction (MI), pressure-volume (PV) measurements are becoming progressively more appreciated as they can longitudinally evaluate the status of the support. Hemodynamically, importance of constant circulatory interrogations by PV during pVAD support lies in its capacity to “fine-tune” the device for a specific patient to work in synergy with the ailing organ. In this review basic characteristics of a diagnostic value of pressure-volume during pVAD hemodynamic support will be discussed fostering conversation about the necessity of e.g. combining pump flow with load-independent indices creating indexes that can be used to further characterize pump unloading in relation to innate cardiac contractility during axial or centrifugal flow support. Additionally, discussion about central hemodynamics during different flow support will be provided evaluating pVADs to assess its ability to work in synergy and to anticipate potential difficulties that might occur during the procedure. Brief description of recent efforts to combine PV exam with pump flow during circulatory support using pVAD and the concept of pressure-volume area (PVA) and myocardial oxygen consumption (mVO2) during unloading will be also discussed.

Published in International Journal of Clinical and Experimental Medical Sciences (Volume 1, Issue 4)
DOI 10.11648/j.ijcems.20150104.11
Page(s) 70-77
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Mechanical Circulatory Support (MCS), Percutaneous Ventricular Assist Device (pVAD), Pressure-Volume (PV), Myocardial Oxygen Consumption (mVO2), Load-Dependent, Load-Independent, Contractility

References
[1] Kolyva C, Pantalos GM, Pepper JR, Khir AW. How much of the intraaortic balloon volume is displaced toward the coronary circulation? J Thorac Cardiovasc Surg. 2010;140(1):110-116.
[2] Bruti G, Kolyva C, Pepper JR, Khir AW. Measurements of Intra-Aortic Balloon Wall Movement During Inflation and Deflation: Effects of Angulation. Artif Organs. 2015;39(8):E154-163.
[3] De Silva K, Lumley M, Kailey B, et al. Coronary and microvascular physiology during intra-aortic balloon counterpulsation. JACC Cardiovasc Interv. 2014;7(6):631-640.
[4] Schreuder JJ, Maisano F, Donelli A, et al. Beat-to-beat effects of intraaortic balloon pump timing on left ventricular performance in patients with low ejection fraction. Ann Thorac Surg. 2005;79(3):872-880.
[5] Salvi P, Revera M, Faini A, et al. Changes in subendocardial viability ratio with acute high-altitude exposure and protective role of acetazolamide. Hypertension. 2013;61(4):793-799.
[6] Buckberg GD, Fixler DE, Archie JP, Hoffman JI. Experimental subendocardial ischemia in dogs with normal coronary arteries. Circ Res. 1972;30:67–81.
[7] Moazami N, Fukamachi K, Kobayashi M, et al. Axial and centrifugal continuous-flow rotary pumps: a translation from pump mechanics to clinical practice. J Heart Lung Transplant. 2013;32(1):1-11.
[8] Hochman JS, Sleeper LA, Webb JG, et al. Early revascularization in acute myocardial infarction complicated by cardiogenic shock. SHOCK Investigators. Should We Emergently Revascularize Occluded Coronaries for Cardiogenic Shock. N Engl J Med. 1999;341(9):625-634.
[9] Møller-Helgestad OK, Poulsen CB, Christiansen EH, Lassen JF, Ravn HB. Support with intra-aortic balloon pump vs. Impella2.5® and blood flow to the heart, brain and kidneys - an experimental porcine model of ischaemic heart failure. Int J Cardiol. 2015;178:153-158.
[10] Mendoza DD, Cooper HA, Panza JA. Cardiac power output predicts mortality across a broad spectrum of patients with acute cardiac disease. Am Heart J. 2007;153(3):366-370.
[11] Wei X, Li T, Hagen B, Zhang P, et al. Short-term mechanical unloading with left ventricular assist devices after acute myocardial infarction conserves calcium cycling and improves heart function. JACC Cardiovasc Interv. 2013;6(4):406-415.
[12] Markert M, Trautmann T, Groß M, Ege A, Mayer K, Guth B. Evaluation of a method to correct the contractility index LVdP/dt(max) for changes in heart rate. J Pharmacol Toxicol Methods. 2012;66(2):98-105.
[13] Johnson DM, Geys R, Lissens J, Guns PJ. Drug-induced effects on cardiovascular function in pentobarbital anesthetized guinea-pigs: invasive LVP measurements versus the QA interval. J Pharmacol Toxicol Methods. 2012;66(2):152-159.
[14] Mooney L, Marks L, Philp KL, Skinner M, Coker SJ, Currie S. Optimising conditions for studying the acute effects of drugs on indices of cardiac contractility and on haemodynamics in anaesthetized guinea pigs. J Pharmacol Toxicol Methods. 2012;66(1):43-51.
[15] McConnell PI, Anstadt MP, Del Rio CL, Preston TJ, Ueyama Y, Youngblood BL. Cardiac function after acute support with direct mechanical ventricular actuation in chronic heart failure. ASAIO J. 2014;60(6):701-706.
[16] Karunanithi MK, Feneley MP. Single-beat determination of preload recruitable stroke work relationship: derivation and evaluation in conscious dogs. J Am Coll Cardiol. 2000;35(2):502-513.
[17] McConnell PI, Del Rio CL, Kwiatkowski P, Farrar DJ, Sun BC. Assessment of cardiac function during axial-flow left ventricular assist device support using a left ventricular pressure-derived relationship: comparison with pre-load recruitable stroke work. J Heart Lung Transplant. 2007;26(2):159-66.
[18] Naiyanetr P, Moscato F, Vollkron M, Zimpfer D, Wieselthaler G, Schima H. Continuous assessment of cardiac function during rotary blood pump support: a contractility index derived from pump flow. J Heart Lung Transplant. 2010;29(1):37-44.
[19] Ferreira AL, Wang Y, Gorcsan J 3rd, Antaki JF. Assessment of cardiac function during mechanical circulatory support: the quest for a suitable clinical index. Conf Proc IEEE Eng Med Biol Soc. 2011;2011:223-226.
[20] Chandola R, Cusimano R, Osten M, Horlick E. Severe aortic insufficiency secondary to 5L Impella device placement. J Card Surg. 2012;27(3):400-402.
[21] Mulukutla S, Schneider L, Cohen HA. Percutaneous mechanical assist devices. In: Feldman A, ed. Heart Failure: Device Management. Hoboken, NJ: Wiley Blackwell; 2010:120–132.
[22] Bakkehaug JP, Kildal AB, Engstad ET, et al. Myosin Activator Omecamtiv Mecarbil Increases Myocardial Oxygen Consumption and Impairs Cardiac Efficiency Mediated by Resting Myosin ATPase Activity. Circ Heart Fail. 2015;8(4):766-775.
[23] Saku K, Kakino T, Sakamoto K, et al. Total unloading of the Left Ventricle by circulatory Assist Device (LVAD) strikingly reduces the infract size in ischemia-reperfusion injury. European Heart Journal. 2013:34. doi: 10.1093/eurheartj/eht309.3692.
Cite This Article
  • APA Style

    Filip Konecny. (2015). Hemodynamic Assessment Using Pressure-Volume (PV) During Mechanical Circulatory Support. International Journal of Clinical and Experimental Medical Sciences, 1(4), 70-77. https://doi.org/10.11648/j.ijcems.20150104.11

    Copy | Download

    ACS Style

    Filip Konecny. Hemodynamic Assessment Using Pressure-Volume (PV) During Mechanical Circulatory Support. Int. J. Clin. Exp. Med. Sci. 2015, 1(4), 70-77. doi: 10.11648/j.ijcems.20150104.11

    Copy | Download

    AMA Style

    Filip Konecny. Hemodynamic Assessment Using Pressure-Volume (PV) During Mechanical Circulatory Support. Int J Clin Exp Med Sci. 2015;1(4):70-77. doi: 10.11648/j.ijcems.20150104.11

    Copy | Download

  • @article{10.11648/j.ijcems.20150104.11,
      author = {Filip Konecny},
      title = {Hemodynamic Assessment Using Pressure-Volume (PV) During Mechanical Circulatory Support},
      journal = {International Journal of Clinical and Experimental Medical Sciences},
      volume = {1},
      number = {4},
      pages = {70-77},
      doi = {10.11648/j.ijcems.20150104.11},
      url = {https://doi.org/10.11648/j.ijcems.20150104.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijcems.20150104.11},
      abstract = {Mechanical circulatory support devices (MCS), namely percutaneous ventricular assist devices (pVAD) are temporarily introduced to support circulation in hemodynamically compromised patients and also during mid to high risk coronary artery procedures. Their multiple responsibilities include maintaining an adequate systemic blood pressure and cardiac output to provide satisfactory end-organ perfusion in unloading of the failing ventricle, and to temporary lower myocardial contractility while reducing myocardial oxygen demand supporting favorable ventricular remodeling. To timely and quantitatively assess hemodynamics during pVAD circulatory support post-cardiogenic shock or acute myocardial infarction (MI), pressure-volume (PV) measurements are becoming progressively more appreciated as they can longitudinally evaluate the status of the support. Hemodynamically, importance of constant circulatory interrogations by PV during pVAD support lies in its capacity to “fine-tune” the device for a specific patient to work in synergy with the ailing organ. In this review basic characteristics of a diagnostic value of pressure-volume during pVAD hemodynamic support will be discussed fostering conversation about the necessity of e.g. combining pump flow with load-independent indices creating indexes that can be used to further characterize pump unloading in relation to innate cardiac contractility during axial or centrifugal flow support. Additionally, discussion about central hemodynamics during different flow support will be provided evaluating pVADs to assess its ability to work in synergy and to anticipate potential difficulties that might occur during the procedure. Brief description of recent efforts to combine PV exam with pump flow during circulatory support using pVAD and the concept of pressure-volume area (PVA) and myocardial oxygen consumption (mVO2) during unloading will be also discussed.},
     year = {2015}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Hemodynamic Assessment Using Pressure-Volume (PV) During Mechanical Circulatory Support
    AU  - Filip Konecny
    Y1  - 2015/12/03
    PY  - 2015
    N1  - https://doi.org/10.11648/j.ijcems.20150104.11
    DO  - 10.11648/j.ijcems.20150104.11
    T2  - International Journal of Clinical and Experimental Medical Sciences
    JF  - International Journal of Clinical and Experimental Medical Sciences
    JO  - International Journal of Clinical and Experimental Medical Sciences
    SP  - 70
    EP  - 77
    PB  - Science Publishing Group
    SN  - 2469-8032
    UR  - https://doi.org/10.11648/j.ijcems.20150104.11
    AB  - Mechanical circulatory support devices (MCS), namely percutaneous ventricular assist devices (pVAD) are temporarily introduced to support circulation in hemodynamically compromised patients and also during mid to high risk coronary artery procedures. Their multiple responsibilities include maintaining an adequate systemic blood pressure and cardiac output to provide satisfactory end-organ perfusion in unloading of the failing ventricle, and to temporary lower myocardial contractility while reducing myocardial oxygen demand supporting favorable ventricular remodeling. To timely and quantitatively assess hemodynamics during pVAD circulatory support post-cardiogenic shock or acute myocardial infarction (MI), pressure-volume (PV) measurements are becoming progressively more appreciated as they can longitudinally evaluate the status of the support. Hemodynamically, importance of constant circulatory interrogations by PV during pVAD support lies in its capacity to “fine-tune” the device for a specific patient to work in synergy with the ailing organ. In this review basic characteristics of a diagnostic value of pressure-volume during pVAD hemodynamic support will be discussed fostering conversation about the necessity of e.g. combining pump flow with load-independent indices creating indexes that can be used to further characterize pump unloading in relation to innate cardiac contractility during axial or centrifugal flow support. Additionally, discussion about central hemodynamics during different flow support will be provided evaluating pVADs to assess its ability to work in synergy and to anticipate potential difficulties that might occur during the procedure. Brief description of recent efforts to combine PV exam with pump flow during circulatory support using pVAD and the concept of pressure-volume area (PVA) and myocardial oxygen consumption (mVO2) during unloading will be also discussed.
    VL  - 1
    IS  - 4
    ER  - 

    Copy | Download

Author Information
  • Department of Surgery, McMaster University, Hamilton, ON, Canada

  • Sections