The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors

Fahimeh Shamsi

doi:doi:10.11648/j.ijpc.20200604.11

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The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors

Fahimeh Shamsi

Published in International Journal of Pharmacy and Chemistry (Volume 6, Issue 4)

Received: 27 June 2020 Accepted: 10 July 2020 Published: 4 August 2020

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Abstract

Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.

Published in	International Journal of Pharmacy and Chemistry (Volume 6, Issue 4)
DOI	10.11648/j.ijpc.20200604.11
Page(s)	37-40
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Peptide Amphiphiles, Tumor Microenvironment, Targeted Delivery, Nanocarriers

References

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APA Style

Fahimeh Shamsi. (2020). The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. International Journal of Pharmacy and Chemistry, 6(4), 37-40. https://doi.org/10.11648/j.ijpc.20200604.11

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ACS Style

Fahimeh Shamsi. The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. Int. J. Pharm. Chem. 2020, 6(4), 37-40. doi: 10.11648/j.ijpc.20200604.11

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AMA Style

Fahimeh Shamsi. The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. Int J Pharm Chem. 2020;6(4):37-40. doi: 10.11648/j.ijpc.20200604.11

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@article{10.11648/j.ijpc.20200604.11,
  author = {Fahimeh Shamsi},
  title = {The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {6},
  number = {4},
  pages = {37-40},
  doi = {10.11648/j.ijpc.20200604.11},
  url = {https://doi.org/10.11648/j.ijpc.20200604.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20200604.11},
  abstract = {Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.},
 year = {2020}
}

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TY  - JOUR
T1  - The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors
AU  - Fahimeh Shamsi
Y1  - 2020/08/04
PY  - 2020
N1  - https://doi.org/10.11648/j.ijpc.20200604.11
DO  - 10.11648/j.ijpc.20200604.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 37
EP  - 40
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20200604.11
AB  - Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.
VL  - 6
IS  - 4
ER  -

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Author Information

Fahimeh Shamsi

Biotechnology Research Centre, Semnan University of Medical Sciences, Semnan, Iran; School of Chemical and Bimolecular Engineering, University of Sydney, Sydney, Australia

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Plain Text BibTeX RIS

APA Style

Fahimeh Shamsi. (2020). The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. International Journal of Pharmacy and Chemistry, 6(4), 37-40. https://doi.org/10.11648/j.ijpc.20200604.11

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ACS Style

Fahimeh Shamsi. The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. Int. J. Pharm. Chem. 2020, 6(4), 37-40. doi: 10.11648/j.ijpc.20200604.11

Copy | Download

AMA Style

Fahimeh Shamsi. The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors. Int J Pharm Chem. 2020;6(4):37-40. doi: 10.11648/j.ijpc.20200604.11

Copy | Download

@article{10.11648/j.ijpc.20200604.11,
  author = {Fahimeh Shamsi},
  title = {The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors},
  journal = {International Journal of Pharmacy and Chemistry},
  volume = {6},
  number = {4},
  pages = {37-40},
  doi = {10.11648/j.ijpc.20200604.11},
  url = {https://doi.org/10.11648/j.ijpc.20200604.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijpc.20200604.11},
  abstract = {Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - The Potential Role of the Peptide Amphiphiles in Targeted Drug Delivery to Tumors
AU  - Fahimeh Shamsi
Y1  - 2020/08/04
PY  - 2020
N1  - https://doi.org/10.11648/j.ijpc.20200604.11
DO  - 10.11648/j.ijpc.20200604.11
T2  - International Journal of Pharmacy and Chemistry
JF  - International Journal of Pharmacy and Chemistry
JO  - International Journal of Pharmacy and Chemistry
SP  - 37
EP  - 40
PB  - Science Publishing Group
SN  - 2575-5749
UR  - https://doi.org/10.11648/j.ijpc.20200604.11
AB  - Background: Targeted drug delivery approaches are intended to increase the effectiveness of drugs by carrying large doses of chemotherapeutic agents to the cancer cells and reduce negative side effects. Self-assembly of peptides can organize molecules into stable and well-defined nanostructures being very attractive for many biomedical applications including drug delivery. Objective: The objective of the current mini-review is to investigate the self-assembly behavior of peptide amphiphiles as nanocarriers under different biological factors in the tumor microenvironment. Method: Data from a range of resources like Google Scholar, PubMed, Medline, Scopus and Elsevier, and other valued journals have been reviewed carefully. Results: Structural changes of peptide amphiphiles in response to tumor microenvironment or tumor-specific enzymes are the promising trend, allowing the development of targeted therapy with high efficiency. However, significant improvement in cytotoxicity is achieved when peptide amphiphiles are designed in such a way to respond to multiple stimuli in tumor microenvironments. Conclusion: A multi- disciplinary research area may permit both to reduce the off-target side effects of anticancer drugs and achieve triggered drug delivery at disease sites.
VL  - 6
IS  - 4
ER  -

Copy | Download