Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in <i>Plasmodium berghi-berghi</i> Infected Mice Treated with <i>Hippocratea africana</i> Root Bark Extract

Jessie Idongesit Ndem; Eno-Obong Ikpeme Bassey; Blessing Obinaju Effiong; Utibe Evans Bassey; Sylvester Daniel Ini

doi:doi:10.11648/j.jdmp.20190504.12

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Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract

Jessie Idongesit Ndem, Eno-Obong Ikpeme Bassey, Blessing Obinaju Effiong, Utibe Evans Bassey, Sylvester Daniel Ini

Received: 13 August 2019 Accepted: 5 September 2019 Published: 12 October 2019

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Abstract

The haematopoietic potential of Jatropha tanjorensis leaf extract in Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract was investigated. Thirty (21) adult mice weighing 27 – 33g were divided into seven (7) groups with three (3) animals in each group. Group 1 served as normal control while Groups 2 – 7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control (parasitized and untreated) group. Group 3 was administered 8mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200mg/kg bw and 300mg/kg bw of extracts of Hippocratea africana and Jatropha tanjorensis respectively for 4 days. Group 6 received 8mg/kg bw of artemether-lumefantrine for 3 days followed with 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Group 7 was treated with 200mg/kg bw of Hippocratea africana root extract for 4 days followed by 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Significant anti-plasmodial activity was observed with artemether-lumefantrine and Hippocratea africana root bark extract administration. Plasmodium berghi-berghi infection induced alterations in haematological indices such as decreased RBC count, platelet count, haemoglobin concentration and heamatocrit and increased WBC count. Administration of Jatropha tanjorensis leaf extract showed improved haematological indices particularly in the red blood cell counts and haemoglobin concentration. Jatropha tanjorensis has haematopoietic activity in Plasmodium berghi-berghi infected mice treated Hippocratea africana root bark extract.

DOI	10.11648/j.jdmp.20190504.12
Published in	Journal of Diseases and Medicinal Plants (Volume 5, Issue 4, August 2019)
Page(s)	69-73
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Jatropha tanjorensis, Hippocratea africana, Artemether-Lumefantrine, Antiplasmodial Activity, Haemato-protection

References

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[2]	Ndem, J. I. and Bassey, U. E. 2017. Parasitaemia Reduction and Moderately Improved Haematological Indices Potentials of Hippocratea africana Root Bark Extract in Plasmodium berghei-berghei Infected Mice. World Journal of Pharmaceutical Research, 6 (4): 63-74.
[3]	Ijarotimi, S., Agbedahunsi, J. M., Onyeji, C. O. and Adewunmi, C. O. 2010. Chemotherapeutic action between Khaya grandifoliola steam bark extract and two antimalarial drugs in mice. African journal of traditional, complementary and alternative medicine, 7 (4): 370-376.
[4]	Adebayo, J. O. and Malomo, S. O. 2002. The Effect of Co-administration of Dihydroartemisinin with Vitamin E on the Activities of Cation ATPases in some Rat Tissues. Nigerian Journal of Pure and Applied Sciences, 17: 1245-1252.
[5]	Ndem, J. I., Eteng, M. U. and Uwah, A. F. 2014. Effect of Hippocratea africana Root Bark Extract on Lipid Profile of Female and Male Albino Wistar Rats. Journal of Scientific Research and Reports, 3 (19): 2574-2583.
[6]	Okokon, J. E., Ita, B. N. and Udokpoh, A. E. 2006. The in vivo Antimalarial Activities of Uvariae chamae and Hippocratea africana. Annals of Tropical Medicine and Parasitology, 100 (9): 585-590.
[7]	Burkill, H. M. 1985. The useful plants of west tropical Africa (2nd ed.). Royal Botanic Gardens Sknew. pp 353-354.
[8]	Atansuyi, K., Ibukun, E. O. and Ogunmyole, T. 2012. Antioxidant properties of free and bound phenolic extract of Jatropha tanjorensis in vitro. Journal of medicinal Plants research, 6 (31): 4667-7415.
[9]	Falodun, A., Udu-Cosi, A. A., Erharuyi, O., Imieje, V., Falodun, E. J., Agbonlahor, O. and Hamann, M. T. 2013. Jatropha tanjorensis – Review of phytochemistry, pharmacology and pharmacotherapy. Journal of pharmaceutical and allied sciences, 10 (3): 1955-1964.
[10]	Maina, R. N., Walsh, D., Gaddy, C., Hongo, G., Waitumbi, J., Otieno, L., Jones, D. and Ogutu, B. R. 2010. Impact of Plasmodium falciparum infection on haematological parameters in children living in Western Kenya. Malaria journal, 9 (Suppl 3): S4.
[11]	Centre of Disease Control (CDC) and Prevention. 2013. Global health division of parasitic diseases and malaria, Atlanta, USA.
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[13]	Iwalewa, E. O., Adewunmi, C. O., Omisore, N. O., Adebanji, O. A. and Azikeet, C. K. 2005. Pro-antioxidant effects and cytoprotective potentials of nine edible vegetables in south west Nigeria. J. med. Food, 8: 539-544.
[14]	Scharf, R. E. 2012. Drugs that affect platelet function. Semin thromb hemost 38 (8): 865-883.
[15]	Mc Ewen, B. J. 2015. The influence of herbal medicine on platelet function and coagulation; A narrative review. Semin thromb hemost 41 (3): 300-314.
[16]	Akpanabiatu, M. I., Akpan, H., Bassey, U. E. and Ufot, U. F. 2016. Infleunce of Nauclea latifolia Leaf Extracts on Some Haematological Parameters of Rats on Coconut Oil and Non-Coconut Oil Meals. European Journal of Medicinal Plants, 17 (4): 1-6.
[17]	Finbarrs-Bello, E., Nto, N. J., Ikele, I. T., Sani, M. I. and Atuadu, V. 2016. Haematopoietic enhancing effect of ethanol seed extract of Citrullus lanatus (watermelon) on bone marrow of Wistar rats. European journal of medicinal plants, 17 (3): 1-7.
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APA Style

Jessie Idongesit Ndem, Eno-Obong Ikpeme Bassey, Blessing Obinaju Effiong, Utibe Evans Bassey, Sylvester Daniel Ini. (2019). Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract. Journal of Diseases and Medicinal Plants, 5(4), 69-73. https://doi.org/10.11648/j.jdmp.20190504.12

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ACS Style

Jessie Idongesit Ndem; Eno-Obong Ikpeme Bassey; Blessing Obinaju Effiong; Utibe Evans Bassey; Sylvester Daniel Ini. Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract. J. Dis. Med. Plants 2019, 5(4), 69-73. doi: 10.11648/j.jdmp.20190504.12

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AMA Style

Jessie Idongesit Ndem, Eno-Obong Ikpeme Bassey, Blessing Obinaju Effiong, Utibe Evans Bassey, Sylvester Daniel Ini. Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract. J Dis Med Plants. 2019;5(4):69-73. doi: 10.11648/j.jdmp.20190504.12

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@article{10.11648/j.jdmp.20190504.12,
  author = {Jessie Idongesit Ndem and Eno-Obong Ikpeme Bassey and Blessing Obinaju Effiong and Utibe Evans Bassey and Sylvester Daniel Ini},
  title = {Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {5},
  number = {4},
  pages = {69-73},
  doi = {10.11648/j.jdmp.20190504.12},
  url = {https://doi.org/10.11648/j.jdmp.20190504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20190504.12},
  abstract = {The haematopoietic potential of Jatropha tanjorensis leaf extract in Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract was investigated. Thirty (21) adult mice weighing 27 – 33g were divided into seven (7) groups with three (3) animals in each group. Group 1 served as normal control while Groups 2 – 7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control (parasitized and untreated) group. Group 3 was administered 8mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200mg/kg bw and 300mg/kg bw of extracts of Hippocratea africana and Jatropha tanjorensis respectively for 4 days. Group 6 received 8mg/kg bw of artemether-lumefantrine for 3 days followed with 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Group 7 was treated with 200mg/kg bw of Hippocratea africana root extract for 4 days followed by 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Significant anti-plasmodial activity was observed with artemether-lumefantrine and Hippocratea africana root bark extract administration. Plasmodium berghi-berghi infection induced alterations in haematological indices such as decreased RBC count, platelet count, haemoglobin concentration and heamatocrit and increased WBC count. Administration of Jatropha tanjorensis leaf extract showed improved haematological indices particularly in the red blood cell counts and haemoglobin concentration. Jatropha tanjorensis has haematopoietic activity in Plasmodium berghi-berghi infected mice treated Hippocratea africana root bark extract.},
 year = {2019}
}

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TY  - JOUR
T1  - Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract
AU  - Jessie Idongesit Ndem
AU  - Eno-Obong Ikpeme Bassey
AU  - Blessing Obinaju Effiong
AU  - Utibe Evans Bassey
AU  - Sylvester Daniel Ini
Y1  - 2019/10/12
PY  - 2019
N1  - https://doi.org/10.11648/j.jdmp.20190504.12
DO  - 10.11648/j.jdmp.20190504.12
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 69
EP  - 73
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20190504.12
AB  - The haematopoietic potential of Jatropha tanjorensis leaf extract in Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract was investigated. Thirty (21) adult mice weighing 27 – 33g were divided into seven (7) groups with three (3) animals in each group. Group 1 served as normal control while Groups 2 – 7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control (parasitized and untreated) group. Group 3 was administered 8mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200mg/kg bw and 300mg/kg bw of extracts of Hippocratea africana and Jatropha tanjorensis respectively for 4 days. Group 6 received 8mg/kg bw of artemether-lumefantrine for 3 days followed with 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Group 7 was treated with 200mg/kg bw of Hippocratea africana root extract for 4 days followed by 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Significant anti-plasmodial activity was observed with artemether-lumefantrine and Hippocratea africana root bark extract administration. Plasmodium berghi-berghi infection induced alterations in haematological indices such as decreased RBC count, platelet count, haemoglobin concentration and heamatocrit and increased WBC count. Administration of Jatropha tanjorensis leaf extract showed improved haematological indices particularly in the red blood cell counts and haemoglobin concentration. Jatropha tanjorensis has haematopoietic activity in Plasmodium berghi-berghi infected mice treated Hippocratea africana root bark extract.
VL  - 5
IS  - 4
ER  -

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Author Information

Jessie Idongesit Ndem

Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
Eno-Obong Ikpeme Bassey

Department of Anatomy, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
Blessing Obinaju Effiong

Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria
Utibe Evans Bassey

Department of Biochemistry, Faculty of Natural and Applied Sciences, Obong University, Etim Ekpo, Nigeria
Sylvester Daniel Ini

Department of Biochemistry, Faculty of Basic Medical Sciences, University of Uyo, Uyo, Nigeria

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Plain Text BibTeX RIS

APA Style

Jessie Idongesit Ndem, Eno-Obong Ikpeme Bassey, Blessing Obinaju Effiong, Utibe Evans Bassey, Sylvester Daniel Ini. (2019). Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract. Journal of Diseases and Medicinal Plants, 5(4), 69-73. https://doi.org/10.11648/j.jdmp.20190504.12

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ACS Style

Jessie Idongesit Ndem; Eno-Obong Ikpeme Bassey; Blessing Obinaju Effiong; Utibe Evans Bassey; Sylvester Daniel Ini. Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract. J. Dis. Med. Plants 2019, 5(4), 69-73. doi: 10.11648/j.jdmp.20190504.12

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AMA Style

Jessie Idongesit Ndem, Eno-Obong Ikpeme Bassey, Blessing Obinaju Effiong, Utibe Evans Bassey, Sylvester Daniel Ini. Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract. J Dis Med Plants. 2019;5(4):69-73. doi: 10.11648/j.jdmp.20190504.12

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@article{10.11648/j.jdmp.20190504.12,
  author = {Jessie Idongesit Ndem and Eno-Obong Ikpeme Bassey and Blessing Obinaju Effiong and Utibe Evans Bassey and Sylvester Daniel Ini},
  title = {Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {5},
  number = {4},
  pages = {69-73},
  doi = {10.11648/j.jdmp.20190504.12},
  url = {https://doi.org/10.11648/j.jdmp.20190504.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20190504.12},
  abstract = {The haematopoietic potential of Jatropha tanjorensis leaf extract in Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract was investigated. Thirty (21) adult mice weighing 27 – 33g were divided into seven (7) groups with three (3) animals in each group. Group 1 served as normal control while Groups 2 – 7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control (parasitized and untreated) group. Group 3 was administered 8mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200mg/kg bw and 300mg/kg bw of extracts of Hippocratea africana and Jatropha tanjorensis respectively for 4 days. Group 6 received 8mg/kg bw of artemether-lumefantrine for 3 days followed with 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Group 7 was treated with 200mg/kg bw of Hippocratea africana root extract for 4 days followed by 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Significant anti-plasmodial activity was observed with artemether-lumefantrine and Hippocratea africana root bark extract administration. Plasmodium berghi-berghi infection induced alterations in haematological indices such as decreased RBC count, platelet count, haemoglobin concentration and heamatocrit and increased WBC count. Administration of Jatropha tanjorensis leaf extract showed improved haematological indices particularly in the red blood cell counts and haemoglobin concentration. Jatropha tanjorensis has haematopoietic activity in Plasmodium berghi-berghi infected mice treated Hippocratea africana root bark extract.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Haematopoietic Potential of Jatropha tanjorensis Leaf Extract in Plasmodium berghi-berghi Infected Mice Treated with Hippocratea africana Root Bark Extract
AU  - Jessie Idongesit Ndem
AU  - Eno-Obong Ikpeme Bassey
AU  - Blessing Obinaju Effiong
AU  - Utibe Evans Bassey
AU  - Sylvester Daniel Ini
Y1  - 2019/10/12
PY  - 2019
N1  - https://doi.org/10.11648/j.jdmp.20190504.12
DO  - 10.11648/j.jdmp.20190504.12
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 69
EP  - 73
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20190504.12
AB  - The haematopoietic potential of Jatropha tanjorensis leaf extract in Plasmodium berghi-berghi infected mice treated with Hippocratea africana root bark extract was investigated. Thirty (21) adult mice weighing 27 – 33g were divided into seven (7) groups with three (3) animals in each group. Group 1 served as normal control while Groups 2 – 7 were parasitized with Plasmodium berghi-berghi and Group 2 was the test control (parasitized and untreated) group. Group 3 was administered 8mg/kg bw of artemether-lumefantrine for 3 days. Group 4 and 5 received daily, 200mg/kg bw and 300mg/kg bw of extracts of Hippocratea africana and Jatropha tanjorensis respectively for 4 days. Group 6 received 8mg/kg bw of artemether-lumefantrine for 3 days followed with 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Group 7 was treated with 200mg/kg bw of Hippocratea africana root extract for 4 days followed by 300mg/kg bw of Jatropha tanjorensis leaf extract for 4 days. Significant anti-plasmodial activity was observed with artemether-lumefantrine and Hippocratea africana root bark extract administration. Plasmodium berghi-berghi infection induced alterations in haematological indices such as decreased RBC count, platelet count, haemoglobin concentration and heamatocrit and increased WBC count. Administration of Jatropha tanjorensis leaf extract showed improved haematological indices particularly in the red blood cell counts and haemoglobin concentration. Jatropha tanjorensis has haematopoietic activity in Plasmodium berghi-berghi infected mice treated Hippocratea africana root bark extract.
VL  - 5
IS  - 4
ER  -

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