Fatty Alcohols Isolated from <i>Prosopis africana</i> and Evaluation of Antibacterial and Antituberculosis Activities

Nganso Ditchou Yves Oscar; Soh Desire; Ndogo Eteme Olivier; Mala Opono M. T. G.; Nyasse Barthelemy

doi:doi:10.11648/j.jdmp.20180405.12

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Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities

Nganso Ditchou Yves Oscar, Soh Desire, Ndogo Eteme Olivier, Mala Opono M. T. G., Nyasse Barthelemy

Published in Journal of Diseases and Medicinal Plants (Volume 4, Issue 5)

Received: 6 October 2018 Accepted: 5 November 2018 Published: 3 December 2018

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Abstract

Prosopis africana, Family Leguminoceae, is used in ethnomedicine to treat different ailments including, diarrhoea, bacillary dysentery, malaria, male sterility and as a cardiotonic. This research aims at evaluating the antibacterial and antituberculosis activities of fatty alcohol. Heneicosanol (1), hexacosanol (2), nonacosanol (3), β-sitosterol (4), quercetin (5), β-sitosterol 3-O-β-D-glucopyranoside (6) and quercitrin (7) were isolated from the leaves of Prosopis africana. Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. Heneicosanol (1), hexacosanol (2), nonacosanol (3) were isolated for the first time to this plant and was subject of antibacterial and antituberculosis activities. The results of this study suggest that the compounds 1, 2, 3 had an MBC a respective value of 1.56 µg/mL, 1.62 µg/mL, 0.12 µg/mL against M. smegmatis, M. tuberculosis. The study of fatty alcohols provides evidence of activity against clinical isolate of mycobacteria, significant anti-inflammatory and analgesic properties, and provides a basis for its possible use as an affordable and effective Antituberculosis agent from natural product.

Published in	Journal of Diseases and Medicinal Plants (Volume 4, Issue 5)
DOI	10.11648/j.jdmp.20180405.12
Page(s)	128-132
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Prosopis africana, Fatty Alcohols, Antibacterial Activities, Antituberculosis Activities

References

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APA Style

Nganso Ditchou Yves Oscar, Soh Desire, Ndogo Eteme Olivier, Mala Opono M. T. G., Nyasse Barthelemy. (2018). Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities. Journal of Diseases and Medicinal Plants, 4(5), 128-132. https://doi.org/10.11648/j.jdmp.20180405.12

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ACS Style

Nganso Ditchou Yves Oscar; Soh Desire; Ndogo Eteme Olivier; Mala Opono M. T. G.; Nyasse Barthelemy. Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities. J. Dis. Med. Plants 2018, 4(5), 128-132. doi: 10.11648/j.jdmp.20180405.12

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AMA Style

Nganso Ditchou Yves Oscar, Soh Desire, Ndogo Eteme Olivier, Mala Opono M. T. G., Nyasse Barthelemy. Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities. J Dis Med Plants. 2018;4(5):128-132. doi: 10.11648/j.jdmp.20180405.12

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@article{10.11648/j.jdmp.20180405.12,
  author = {Nganso Ditchou Yves Oscar and Soh Desire and Ndogo Eteme Olivier and Mala Opono M. T. G. and Nyasse Barthelemy},
  title = {Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {4},
  number = {5},
  pages = {128-132},
  doi = {10.11648/j.jdmp.20180405.12},
  url = {https://doi.org/10.11648/j.jdmp.20180405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20180405.12},
  abstract = {Prosopis africana, Family Leguminoceae, is used in ethnomedicine to treat different ailments including, diarrhoea, bacillary dysentery, malaria, male sterility and as a cardiotonic. This research aims at evaluating the antibacterial and antituberculosis activities of fatty alcohol. Heneicosanol (1), hexacosanol (2), nonacosanol (3), β-sitosterol (4), quercetin (5), β-sitosterol 3-O-β-D-glucopyranoside (6) and quercitrin (7) were isolated from the leaves of Prosopis africana. Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. Heneicosanol (1), hexacosanol (2), nonacosanol (3) were isolated for the first time to this plant and was subject of antibacterial and antituberculosis activities. The results of this study suggest that the compounds 1, 2, 3 had an MBC a respective value of 1.56 µg/mL, 1.62 µg/mL, 0.12 µg/mL against M. smegmatis, M. tuberculosis. The study of fatty alcohols provides evidence of activity against clinical isolate of mycobacteria, significant anti-inflammatory and analgesic properties, and provides a basis for its possible use as an affordable and effective Antituberculosis agent from natural product.},
 year = {2018}
}

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TY - JOUR
T1 - Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities
AU - Nganso Ditchou Yves Oscar
AU - Soh Desire
AU - Ndogo Eteme Olivier
AU - Mala Opono M. T. G.
AU - Nyasse Barthelemy
Y1 - 2018/12/03
PY - 2018
N1 - https://doi.org/10.11648/j.jdmp.20180405.12
DO - 10.11648/j.jdmp.20180405.12
T2 - Journal of Diseases and Medicinal Plants
JF - Journal of Diseases and Medicinal Plants
JO - Journal of Diseases and Medicinal Plants
SP - 128
EP - 132
PB - Science Publishing Group
SN - 2469-8210
UR - https://doi.org/10.11648/j.jdmp.20180405.12
AB - Prosopis africana, Family Leguminoceae, is used in ethnomedicine to treat different ailments including, diarrhoea, bacillary dysentery, malaria, male sterility and as a cardiotonic. This research aims at evaluating the antibacterial and antituberculosis activities of fatty alcohol. Heneicosanol (1), hexacosanol (2), nonacosanol (3), β-sitosterol (4), quercetin (5), β-sitosterol 3-O-β-D-glucopyranoside (6) and quercitrin (7) were isolated from the leaves of Prosopis africana. Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. Heneicosanol (1), hexacosanol (2), nonacosanol (3) were isolated for the first time to this plant and was subject of antibacterial and antituberculosis activities. The results of this study suggest that the compounds 1, 2, 3 had an MBC a respective value of 1.56 µg/mL, 1.62 µg/mL, 0.12 µg/mL against M. smegmatis, M. tuberculosis. The study of fatty alcohols provides evidence of activity against clinical isolate of mycobacteria, significant anti-inflammatory and analgesic properties, and provides a basis for its possible use as an affordable and effective Antituberculosis agent from natural product.
VL - 4
IS - 5
ER -

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Author Information

Nganso Ditchou Yves Oscar

Department of Chemistry, Faculty of Science, University of Maroua, Maroua, Cameroon
Soh Desire

Department of Organic Chemistry, Higher Teachers Training College, University of Bamenda, Bamenda, Cameroon
Ndogo Eteme Olivier

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
Mala Opono M. T. G.

Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
Nyasse Barthelemy

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon

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APA Style

Nganso Ditchou Yves Oscar, Soh Desire, Ndogo Eteme Olivier, Mala Opono M. T. G., Nyasse Barthelemy. (2018). Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities. Journal of Diseases and Medicinal Plants, 4(5), 128-132. https://doi.org/10.11648/j.jdmp.20180405.12

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ACS Style

Nganso Ditchou Yves Oscar; Soh Desire; Ndogo Eteme Olivier; Mala Opono M. T. G.; Nyasse Barthelemy. Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities. J. Dis. Med. Plants 2018, 4(5), 128-132. doi: 10.11648/j.jdmp.20180405.12

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AMA Style

Nganso Ditchou Yves Oscar, Soh Desire, Ndogo Eteme Olivier, Mala Opono M. T. G., Nyasse Barthelemy. Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities. J Dis Med Plants. 2018;4(5):128-132. doi: 10.11648/j.jdmp.20180405.12

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@article{10.11648/j.jdmp.20180405.12,
  author = {Nganso Ditchou Yves Oscar and Soh Desire and Ndogo Eteme Olivier and Mala Opono M. T. G. and Nyasse Barthelemy},
  title = {Fatty Alcohols Isolated from Prosopis africana and Evaluation of Antibacterial and Antituberculosis Activities},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {4},
  number = {5},
  pages = {128-132},
  doi = {10.11648/j.jdmp.20180405.12},
  url = {https://doi.org/10.11648/j.jdmp.20180405.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20180405.12},
  abstract = {Prosopis africana, Family Leguminoceae, is used in ethnomedicine to treat different ailments including, diarrhoea, bacillary dysentery, malaria, male sterility and as a cardiotonic. This research aims at evaluating the antibacterial and antituberculosis activities of fatty alcohol. Heneicosanol (1), hexacosanol (2), nonacosanol (3), β-sitosterol (4), quercetin (5), β-sitosterol 3-O-β-D-glucopyranoside (6) and quercitrin (7) were isolated from the leaves of Prosopis africana. Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. Heneicosanol (1), hexacosanol (2), nonacosanol (3) were isolated for the first time to this plant and was subject of antibacterial and antituberculosis activities. The results of this study suggest that the compounds 1, 2, 3 had an MBC a respective value of 1.56 µg/mL, 1.62 µg/mL, 0.12 µg/mL against M. smegmatis, M. tuberculosis. The study of fatty alcohols provides evidence of activity against clinical isolate of mycobacteria, significant anti-inflammatory and analgesic properties, and provides a basis for its possible use as an affordable and effective Antituberculosis agent from natural product.},
 year = {2018}
}

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