Chemical Constituents of <sup>Clerodendrum splendens</sup> (Lamiaceae) and Their Antioxidant Activities

Nganso Ditchou Yves Oscar; Tatsimo Ndendoung Simplice Joel; Amang A. Ngoung Gabrielle Ange; Soh Desire; Simo Nemg Fredy Brice; Nyasse Barthelemy

doi:doi:10.11648/j.jdmp.20180405.11

Chemical Constituents of ^{Clerodendrum splendens} (Lamiaceae) and Their Antioxidant Activities

Nganso Ditchou Yves Oscar, Tatsimo Ndendoung Simplice Joel, Amang A. Ngoung Gabrielle Ange, Soh Desire, Simo Nemg Fredy Brice, Nyasse Barthelemy

Published in Journal of Diseases and Medicinal Plants (Volume 4, Issue 5)

Received: 11 October 2018 Accepted: 29 October 2018 Published: 21 November 2018

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Abstract

The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe²⁺. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC₅₀ of the different compounds. Furthermore, the compounds 1 and 2 have higher IC₅₀ than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.

Published in	Journal of Diseases and Medicinal Plants (Volume 4, Issue 5)
DOI	10.11648/j.jdmp.20180405.11
Page(s)	120-127
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Clerodendrum splendens, Lamiaceae, Antioxidant Activities, Secondary Metabolites

References

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[16]	Toshihiro A, Toshitake T, Taro M (1990). ‹‹(22Z, 24S)-Stigmastra-5,22,25-trien-3β-oland Other Novel Sterols from Clerodendrum scandens: first report of the Isolation of a cis-∆22 – Unsaturated Sterol from a Higher Plant›› Journal of chemistry society of Perkin Trans, 1: 2013-2018.
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Nganso Ditchou Yves Oscar, Tatsimo Ndendoung Simplice Joel, Amang A. Ngoung Gabrielle Ange, Soh Desire, Simo Nemg Fredy Brice, et al. (2018). Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities. Journal of Diseases and Medicinal Plants, 4(5), 120-127. https://doi.org/10.11648/j.jdmp.20180405.11

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ACS Style

Nganso Ditchou Yves Oscar; Tatsimo Ndendoung Simplice Joel; Amang A. Ngoung Gabrielle Ange; Soh Desire; Simo Nemg Fredy Brice, et al. Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities. J. Dis. Med. Plants 2018, 4(5), 120-127. doi: 10.11648/j.jdmp.20180405.11

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AMA Style

Nganso Ditchou Yves Oscar, Tatsimo Ndendoung Simplice Joel, Amang A. Ngoung Gabrielle Ange, Soh Desire, Simo Nemg Fredy Brice, et al. Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities. J Dis Med Plants. 2018;4(5):120-127. doi: 10.11648/j.jdmp.20180405.11

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@article{10.11648/j.jdmp.20180405.11,
  author = {Nganso Ditchou Yves Oscar and Tatsimo Ndendoung Simplice Joel and Amang A. Ngoung Gabrielle Ange and Soh Desire and Simo Nemg Fredy Brice and Nyasse Barthelemy},
  title = {Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {4},
  number = {5},
  pages = {120-127},
  doi = {10.11648/j.jdmp.20180405.11},
  url = {https://doi.org/10.11648/j.jdmp.20180405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20180405.11},
  abstract = {The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe2+. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC50 of the different compounds. Furthermore, the compounds 1 and 2 have higher IC50 than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.},
 year = {2018}
}

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TY  - JOUR
T1  - Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities
AU  - Nganso Ditchou Yves Oscar
AU  - Tatsimo Ndendoung Simplice Joel
AU  - Amang A. Ngoung Gabrielle Ange
AU  - Soh Desire
AU  - Simo Nemg Fredy Brice
AU  - Nyasse Barthelemy
Y1  - 2018/11/21
PY  - 2018
N1  - https://doi.org/10.11648/j.jdmp.20180405.11
DO  - 10.11648/j.jdmp.20180405.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 120
EP  - 127
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20180405.11
AB  - The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe2+. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC50 of the different compounds. Furthermore, the compounds 1 and 2 have higher IC50 than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.
VL  - 4
IS  - 5
ER  -

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Author Information

Nganso Ditchou Yves Oscar

Department of Chemistry, Faculty of Science, University of Maroua, Maroua, Cameroon
Tatsimo Ndendoung Simplice Joel

Department of Chemistry, Higher Teachers’ Training College, University of Maroua, Maroua, Cameroon
Amang A. Ngoung Gabrielle Ange

Department of Chemistry, Faculty of Science, University of Maroua, Maroua, Cameroon
Soh Desire

Department of Organic Chemistry, Higher Teachers’ Training College, University of Bamenda, Bamenda, Cameroon
Simo Nemg Fredy Brice

Department of Biochemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon
Nyasse Barthelemy

Department of Organic Chemistry, Faculty of Science, University of Yaounde I, Yaounde, Cameroon

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APA Style

Nganso Ditchou Yves Oscar, Tatsimo Ndendoung Simplice Joel, Amang A. Ngoung Gabrielle Ange, Soh Desire, Simo Nemg Fredy Brice, et al. (2018). Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities. Journal of Diseases and Medicinal Plants, 4(5), 120-127. https://doi.org/10.11648/j.jdmp.20180405.11

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ACS Style

Nganso Ditchou Yves Oscar; Tatsimo Ndendoung Simplice Joel; Amang A. Ngoung Gabrielle Ange; Soh Desire; Simo Nemg Fredy Brice, et al. Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities. J. Dis. Med. Plants 2018, 4(5), 120-127. doi: 10.11648/j.jdmp.20180405.11

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AMA Style

Nganso Ditchou Yves Oscar, Tatsimo Ndendoung Simplice Joel, Amang A. Ngoung Gabrielle Ange, Soh Desire, Simo Nemg Fredy Brice, et al. Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities. J Dis Med Plants. 2018;4(5):120-127. doi: 10.11648/j.jdmp.20180405.11

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@article{10.11648/j.jdmp.20180405.11,
  author = {Nganso Ditchou Yves Oscar and Tatsimo Ndendoung Simplice Joel and Amang A. Ngoung Gabrielle Ange and Soh Desire and Simo Nemg Fredy Brice and Nyasse Barthelemy},
  title = {Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities},
  journal = {Journal of Diseases and Medicinal Plants},
  volume = {4},
  number = {5},
  pages = {120-127},
  doi = {10.11648/j.jdmp.20180405.11},
  url = {https://doi.org/10.11648/j.jdmp.20180405.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jdmp.20180405.11},
  abstract = {The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe2+. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC50 of the different compounds. Furthermore, the compounds 1 and 2 have higher IC50 than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.},
 year = {2018}
}

Copy | Download

TY  - JOUR
T1  - Chemical Constituents of Clerodendrum splendens (Lamiaceae) and Their Antioxidant Activities
AU  - Nganso Ditchou Yves Oscar
AU  - Tatsimo Ndendoung Simplice Joel
AU  - Amang A. Ngoung Gabrielle Ange
AU  - Soh Desire
AU  - Simo Nemg Fredy Brice
AU  - Nyasse Barthelemy
Y1  - 2018/11/21
PY  - 2018
N1  - https://doi.org/10.11648/j.jdmp.20180405.11
DO  - 10.11648/j.jdmp.20180405.11
T2  - Journal of Diseases and Medicinal Plants
JF  - Journal of Diseases and Medicinal Plants
JO  - Journal of Diseases and Medicinal Plants
SP  - 120
EP  - 127
PB  - Science Publishing Group
SN  - 2469-8210
UR  - https://doi.org/10.11648/j.jdmp.20180405.11
AB  - The purpose of this study was to evaluate the antioxidant activity of compounds isolated from Clerodendrum splendens leaves. The leaves of Clerodendrum splendens are used in traditional medicine by indegenous people to treat shingles, spleen in children, asthma, rheumatism, ulcers and malaria. In vivo and in vitro studies carried out by many researchers have shown that Clerodendrum splendens has antioxidant properties. The chemical study of the methanol extract of Clerodendrum splendens leaves (Lamiaceae) led to the isolation of three compounds: Triancontanol (1), (22E, 24S) - Stigmasta - 5, 22, 25 - trien – 3β-ol(2); 3-O-D-glucopyranoside of (22E, 24S) - Stigmasta - 5,22,25 - trien - 3β-ol (3). Their structures were elucidated on the basis of a spectroscopic analysis and a comparison of their data spectral with those reported in the literature. The results of the antioxidant activity have shown that the compounds 1 and 2 inhibit the peroxidation of the hepatic lipids, they also show that the compounds 1, 2 and 3 have a reducing effect on Fe2+. However, the compounds 1, 2 and 3 have an OH reduction power which is directly proportional to the concentration of these compounds compared to that of vitamin C, which made it possible to determine the IC50 of the different compounds. Furthermore, the compounds 1 and 2 have higher IC50 than that of vitamin C (5.613 ± 0.117). The results of this study suggest that Clerodendrum splendens represents an untapped source of compounds with potential antioxidant activity that could be explored in the development of new therapeutic natural products.
VL  - 4
IS  - 5
ER  -

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