Journal of Diseases and Medicinal Plants

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Evaluation of Antidiabetic Activity of Aqueous Extract of Leaves from Phragmanthera capitata (Sprengel) S. Balle (Laurenthaceae) in Wistar Albino Rats

Received: 23 August 2018    Accepted: 07 September 2018    Published: 09 November 2018
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Abstract

Diabetes mellitus is a public health problem affecting about 8.4% of people in the world and knows an alarming progression in sub-Saharan Africa and in Cameroon precisely. The current therapeutic strategies have prohibitive prices, are unavailable and have harmful side-effects. So, this work aimed at contributing to the valorization of medicinal flora and `knowledge of traditional healers in Foumban, West-Cameroon, in the treatment of diabetes. An ethnopharmacological survey was conducted by consulting traditional healers of the District of Foumban. At the end of this investigation, Phragmanthera capitata, which was found to be the most active plant following preliminary tests, was selected for antidiabetic studies on three groups of rats: normal glycaemia, temporary hyperglycemia and diabetic. The first two groups were treated per os, with aqueous extract of leaves from P. capitata, with the doses of D2 (4 mL/kg) obtained from the traditional healers, D1 (half of D2), D3 (double of D2) and by glibenclamide (2.5 mg/kg). The rats of the last group were treated twice per day, with the same doses of extract and glibenclamide for 13 days and were sacrificed on the 14th day. Their blood was collected by cardiac puncture for the determination of biochemical and hematological parameters. Phytochemical screening was performed using standard methods. The administration of aqueous extract of P. capitata led to a hypoglycaemia effect in normal rats, a reduction of glycaemia in the temporary hyperglycaemia and diabetic rats. In addition, an improvement of lipid assessment, renal and hepatic parameters related to the installation of diabetes, as well as an immune-modulator effect of the extract were noted in diabetic rats treated for 13 days. Phytochemical screening indicated that the extract contains saponins, tannins, flavonoids, steroids and terpens. This work along with findings justifies the traditional use of this plant in the treatment of diabetes mellitus.

DOI 10.11648/j.jdmp.20180404.11
Published in Journal of Diseases and Medicinal Plants (Volume 4, Issue 4, August 2018)
Page(s) 96-109
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetes, Ethnopharmacologic Survey, Phragmanthera capitata, Biochemical Parameters, Hematologic Parameters

References
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Author Information
  • Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon

  • Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon

  • Laboratory of Microbiology and Antimicrobial Substances, Department of Biochemistry, Faculty of Science, University of Dschang, Dschang, Cameroon

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    Cesaire Feudjio, Guy Sedar Singor Njateng, Jules-Roger Kuiate. (2018). Evaluation of Antidiabetic Activity of Aqueous Extract of Leaves from Phragmanthera capitata (Sprengel) S. Balle (Laurenthaceae) in Wistar Albino Rats. Journal of Diseases and Medicinal Plants, 4(4), 96-109. https://doi.org/10.11648/j.jdmp.20180404.11

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    Cesaire Feudjio; Guy Sedar Singor Njateng; Jules-Roger Kuiate. Evaluation of Antidiabetic Activity of Aqueous Extract of Leaves from Phragmanthera capitata (Sprengel) S. Balle (Laurenthaceae) in Wistar Albino Rats. J. Dis. Med. Plants 2018, 4(4), 96-109. doi: 10.11648/j.jdmp.20180404.11

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    AMA Style

    Cesaire Feudjio, Guy Sedar Singor Njateng, Jules-Roger Kuiate. Evaluation of Antidiabetic Activity of Aqueous Extract of Leaves from Phragmanthera capitata (Sprengel) S. Balle (Laurenthaceae) in Wistar Albino Rats. J Dis Med Plants. 2018;4(4):96-109. doi: 10.11648/j.jdmp.20180404.11

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  • @article{10.11648/j.jdmp.20180404.11,
      author = {Cesaire Feudjio and Guy Sedar Singor Njateng and Jules-Roger Kuiate},
      title = {Evaluation of Antidiabetic Activity of Aqueous Extract of Leaves from Phragmanthera capitata (Sprengel) S. Balle (Laurenthaceae) in Wistar Albino Rats},
      journal = {Journal of Diseases and Medicinal Plants},
      volume = {4},
      number = {4},
      pages = {96-109},
      doi = {10.11648/j.jdmp.20180404.11},
      url = {https://doi.org/10.11648/j.jdmp.20180404.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jdmp.20180404.11},
      abstract = {Diabetes mellitus is a public health problem affecting about 8.4% of people in the world and knows an alarming progression in sub-Saharan Africa and in Cameroon precisely. The current therapeutic strategies have prohibitive prices, are unavailable and have harmful side-effects. So, this work aimed at contributing to the valorization of medicinal flora and `knowledge of traditional healers in Foumban, West-Cameroon, in the treatment of diabetes. An ethnopharmacological survey was conducted by consulting traditional healers of the District of Foumban. At the end of this investigation, Phragmanthera capitata, which was found to be the most active plant following preliminary tests, was selected for antidiabetic studies on three groups of rats: normal glycaemia, temporary hyperglycemia and diabetic. The first two groups were treated per os, with aqueous extract of leaves from P. capitata, with the doses of D2 (4 mL/kg) obtained from the traditional healers, D1 (half of D2), D3 (double of D2) and by glibenclamide (2.5 mg/kg). The rats of the last group were treated twice per day, with the same doses of extract and glibenclamide for 13 days and were sacrificed on the 14th day. Their blood was collected by cardiac puncture for the determination of biochemical and hematological parameters. Phytochemical screening was performed using standard methods. The administration of aqueous extract of P. capitata led to a hypoglycaemia effect in normal rats, a reduction of glycaemia in the temporary hyperglycaemia and diabetic rats. In addition, an improvement of lipid assessment, renal and hepatic parameters related to the installation of diabetes, as well as an immune-modulator effect of the extract were noted in diabetic rats treated for 13 days. Phytochemical screening indicated that the extract contains saponins, tannins, flavonoids, steroids and terpens. This work along with findings justifies the traditional use of this plant in the treatment of diabetes mellitus.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Evaluation of Antidiabetic Activity of Aqueous Extract of Leaves from Phragmanthera capitata (Sprengel) S. Balle (Laurenthaceae) in Wistar Albino Rats
    AU  - Cesaire Feudjio
    AU  - Guy Sedar Singor Njateng
    AU  - Jules-Roger Kuiate
    Y1  - 2018/11/09
    PY  - 2018
    N1  - https://doi.org/10.11648/j.jdmp.20180404.11
    DO  - 10.11648/j.jdmp.20180404.11
    T2  - Journal of Diseases and Medicinal Plants
    JF  - Journal of Diseases and Medicinal Plants
    JO  - Journal of Diseases and Medicinal Plants
    SP  - 96
    EP  - 109
    PB  - Science Publishing Group
    SN  - 2469-8210
    UR  - https://doi.org/10.11648/j.jdmp.20180404.11
    AB  - Diabetes mellitus is a public health problem affecting about 8.4% of people in the world and knows an alarming progression in sub-Saharan Africa and in Cameroon precisely. The current therapeutic strategies have prohibitive prices, are unavailable and have harmful side-effects. So, this work aimed at contributing to the valorization of medicinal flora and `knowledge of traditional healers in Foumban, West-Cameroon, in the treatment of diabetes. An ethnopharmacological survey was conducted by consulting traditional healers of the District of Foumban. At the end of this investigation, Phragmanthera capitata, which was found to be the most active plant following preliminary tests, was selected for antidiabetic studies on three groups of rats: normal glycaemia, temporary hyperglycemia and diabetic. The first two groups were treated per os, with aqueous extract of leaves from P. capitata, with the doses of D2 (4 mL/kg) obtained from the traditional healers, D1 (half of D2), D3 (double of D2) and by glibenclamide (2.5 mg/kg). The rats of the last group were treated twice per day, with the same doses of extract and glibenclamide for 13 days and were sacrificed on the 14th day. Their blood was collected by cardiac puncture for the determination of biochemical and hematological parameters. Phytochemical screening was performed using standard methods. The administration of aqueous extract of P. capitata led to a hypoglycaemia effect in normal rats, a reduction of glycaemia in the temporary hyperglycaemia and diabetic rats. In addition, an improvement of lipid assessment, renal and hepatic parameters related to the installation of diabetes, as well as an immune-modulator effect of the extract were noted in diabetic rats treated for 13 days. Phytochemical screening indicated that the extract contains saponins, tannins, flavonoids, steroids and terpens. This work along with findings justifies the traditional use of this plant in the treatment of diabetes mellitus.
    VL  - 4
    IS  - 4
    ER  - 

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