Objective: Determine the serum bilirubin, serum malondialdehyde (MDA) and glycemic control with retinopathy in type 2 Diabetes mellitus. Subjects and Methods: The present case control study was conducted at the Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad from January 2014 to February 2015. 50 type 2 DM (controls group 1) without DR and 50 type 2 DM with DR (cases group 2) were selected. Inclusion and exclusion criteria were followed strictly. RBG, FBG, fasting insulin, HbA1c, blood lipids, serum creatinine and bilirubin were detected and HOMA model was calculated. MDA was estimated by assay kit. Data was analyzed on Statistix 8.1 (USA) software (P ≤ 0.05). Results: Blood glucose, Glycated HbA1, serum creatinine, serum bilirubin and serum malondialdehyde (MDA) showed statistically significant difference (p<0.05). Serum bilirubin was noted as 1.09±0.25 and 0.96±0.21 mg/dl in controls and cases (p=0.005). Serum MDA was significantly elevated in DR cases 5.94±2.02 µmol/dl vs. 3.88±2.24 µmol/dl in controls. Serum bilirubin showed negative correlation with blood glucose, HbA1c and MDA (r-value noted as -0.359, -0.306 and -0.302 respectively). Serum MDA showed positive correlation with blood glucose (r = 0.478) and HbA1c (r = 0.507). Conclusion: The present study reports low serum bilirubin and high serum malondialdehyde levels in diabetic retinopathy.
| Published in | International Journal of Diabetes and Endocrinology (Volume 2, Issue 1) |
| DOI | 10.11648/j.ijde.20170201.13 |
| Page(s) | 10-14 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
Malondialdehyde, Bilirubin, Glycemic Control, Diabetes Mellitus
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APA Style
Shumaila Shaikh, Azhar Memon, Muhammad Atif Ata, Hina, Haji Khan Khoharo. (2017). Association of Serum Bilirubin, Serum Malondialdehyde and Glycemic Control with Retinopathy in Type 2 Diabetic Subjects. International Journal of Diabetes and Endocrinology, 2(1), 10-14. https://doi.org/10.11648/j.ijde.20170201.13
ACS Style
Shumaila Shaikh; Azhar Memon; Muhammad Atif Ata; Hina; Haji Khan Khoharo. Association of Serum Bilirubin, Serum Malondialdehyde and Glycemic Control with Retinopathy in Type 2 Diabetic Subjects. Int. J. Diabetes Endocrinol. 2017, 2(1), 10-14. doi: 10.11648/j.ijde.20170201.13
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Download@article{10.11648/j.ijde.20170201.13,
author = {Shumaila Shaikh and Azhar Memon and Muhammad Atif Ata and Hina and Haji Khan Khoharo},
title = {Association of Serum Bilirubin, Serum Malondialdehyde and Glycemic Control with Retinopathy in Type 2 Diabetic Subjects},
journal = {International Journal of Diabetes and Endocrinology},
volume = {2},
number = {1},
pages = {10-14},
doi = {10.11648/j.ijde.20170201.13},
url = {https://doi.org/10.11648/j.ijde.20170201.13},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ijde.20170201.13},
abstract = {Objective: Determine the serum bilirubin, serum malondialdehyde (MDA) and glycemic control with retinopathy in type 2 Diabetes mellitus. Subjects and Methods: The present case control study was conducted at the Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad from January 2014 to February 2015. 50 type 2 DM (controls group 1) without DR and 50 type 2 DM with DR (cases group 2) were selected. Inclusion and exclusion criteria were followed strictly. RBG, FBG, fasting insulin, HbA1c, blood lipids, serum creatinine and bilirubin were detected and HOMA model was calculated. MDA was estimated by assay kit. Data was analyzed on Statistix 8.1 (USA) software (P ≤ 0.05). Results: Blood glucose, Glycated HbA1, serum creatinine, serum bilirubin and serum malondialdehyde (MDA) showed statistically significant difference (p<0.05). Serum bilirubin was noted as 1.09±0.25 and 0.96±0.21 mg/dl in controls and cases (p=0.005). Serum MDA was significantly elevated in DR cases 5.94±2.02 µmol/dl vs. 3.88±2.24 µmol/dl in controls. Serum bilirubin showed negative correlation with blood glucose, HbA1c and MDA (r-value noted as -0.359, -0.306 and -0.302 respectively). Serum MDA showed positive correlation with blood glucose (r = 0.478) and HbA1c (r = 0.507). Conclusion: The present study reports low serum bilirubin and high serum malondialdehyde levels in diabetic retinopathy.},
year = {2017}
}
TY - JOUR T1 - Association of Serum Bilirubin, Serum Malondialdehyde and Glycemic Control with Retinopathy in Type 2 Diabetic Subjects AU - Shumaila Shaikh AU - Azhar Memon AU - Muhammad Atif Ata AU - Hina AU - Haji Khan Khoharo Y1 - 2017/03/22 PY - 2017 N1 - https://doi.org/10.11648/j.ijde.20170201.13 DO - 10.11648/j.ijde.20170201.13 T2 - International Journal of Diabetes and Endocrinology JF - International Journal of Diabetes and Endocrinology JO - International Journal of Diabetes and Endocrinology SP - 10 EP - 14 PB - Science Publishing Group SN - 2640-1371 UR - https://doi.org/10.11648/j.ijde.20170201.13 AB - Objective: Determine the serum bilirubin, serum malondialdehyde (MDA) and glycemic control with retinopathy in type 2 Diabetes mellitus. Subjects and Methods: The present case control study was conducted at the Department of Medicine, Liaquat University of Medical and Health Sciences Jamshoro/Hyderabad from January 2014 to February 2015. 50 type 2 DM (controls group 1) without DR and 50 type 2 DM with DR (cases group 2) were selected. Inclusion and exclusion criteria were followed strictly. RBG, FBG, fasting insulin, HbA1c, blood lipids, serum creatinine and bilirubin were detected and HOMA model was calculated. MDA was estimated by assay kit. Data was analyzed on Statistix 8.1 (USA) software (P ≤ 0.05). Results: Blood glucose, Glycated HbA1, serum creatinine, serum bilirubin and serum malondialdehyde (MDA) showed statistically significant difference (p<0.05). Serum bilirubin was noted as 1.09±0.25 and 0.96±0.21 mg/dl in controls and cases (p=0.005). Serum MDA was significantly elevated in DR cases 5.94±2.02 µmol/dl vs. 3.88±2.24 µmol/dl in controls. Serum bilirubin showed negative correlation with blood glucose, HbA1c and MDA (r-value noted as -0.359, -0.306 and -0.302 respectively). Serum MDA showed positive correlation with blood glucose (r = 0.478) and HbA1c (r = 0.507). Conclusion: The present study reports low serum bilirubin and high serum malondialdehyde levels in diabetic retinopathy. VL - 2 IS - 1 ER -
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