Symptomatic Disc Herniations: A Review to Understand Pathophysiology and Prediction of Outcomes
Clinical Neurology and Neuroscience
Volume 1, Issue 2, May 2017, Pages: 24-33
Received: Feb. 28, 2017; Accepted: Mar. 24, 2017; Published: Apr. 10, 2017
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Tagbo Ilozue, Department of Neurosurgery, Royal Victoria Infirmary, Newcastle, UK
Mohamed Abdelsadg, Department of Neurosurgery, Ninewells Hospital, Dundee, UK
Avinash Kumar Kanodia, Department of Radiology, Ninewells Hospital, Dundee, UK
Kismet Hossain-Ibrahim, Department of Neurosurgery, Ninewells Hospital, Dundee, UK
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Lumbar disc herniation is a common condition with a significant impact on health and economics worldwide. Although deemed unrequired in the majority of cases; surgery has a cardinal role in the management of this disease. Most patients will experience symptomatic improvement following conservative treatment, in fact some will experience complete recovery of their symptoms. Nonetheless the mechanism behind this spontaneous improvement is currently poorly understood, yet it offers the potential to inform therapeutic options that might promote more rapid recovery and prevent the establishment of long-term complications. This review summarises the available literature on the pathophysiological events occurring following lumbar disc herniation, with some relevant reflections on the clinical picture. Also the review highlights the current gaps in our knowledge, and stresses some of the debatable concepts in managing the disease, in order to identify areas where future research might help explain the process of spontaneous recovery from symptomatic lumbar disc herniations and also suggest direction of further research to have a positive impact about outcomes.
Lumbar Disc Herniation, Disc Prolapse, Pathophysiology, Radiculopathy
To cite this article
Tagbo Ilozue, Mohamed Abdelsadg, Avinash Kumar Kanodia, Kismet Hossain-Ibrahim, Symptomatic Disc Herniations: A Review to Understand Pathophysiology and Prediction of Outcomes, Clinical Neurology and Neuroscience. Vol. 1, No. 2, 2017, pp. 24-33. doi: 10.11648/j.cnn.20170102.11
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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