Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation
Clinical Neurology and Neuroscience
Volume 1, Issue 4, November 2017, Pages: 104-106
Received: Oct. 22, 2017; Accepted: Nov. 6, 2017; Published: Dec. 11, 2017
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Authors
Marcellin Bugeme, Neurological Clinic of the National Teaching Hospital, Université Cheik Anta Diop, Dakar, Senegal
Kegnide Cadnelle Christelle Affognon, Neurological Clinic of the National Teaching Hospital, Université Cheik Anta Diop, Dakar, Senegal
Kouda Daniel Asta, Neurological Clinic of the National Teaching Hospital, Université Cheik Anta Diop, Dakar, Senegal
Salahedine Mourabit, Neurological Clinic of the National Teaching Hospital, Université Cheik Anta Diop, Dakar, Senegal
Olivier Mukuku, Department de Recherche, Institut Supérieur des Techniques Médicales de Lubumbaashi, Lubumbashi, Democratic Republic of Congo
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Abstract
Devic’s Neuromyelitis Optica (NMO) is a rare demyelinating disorder affecting the optic nerves and spinal cord, with a relative brain saving. The diagnosis involves optic neuropathy and acute myelitis. The dosage of anti-aquaporin-4 autoantibodies is generally positive, but its negativity does not call into question the diagnosis. We report the case of a 34-year-old woman admitted to the Department of Neurology at the Fann University Hospital in Dakar for visual impairment and motor deficiency in the lower limbs of rapidly progressive onset in which clinical examination has revealed right monocular blindness and transverse myelitis. Medullary MRI and VEP enabled us to make the definitive diagnosis of optic neuromyelitis despite the negativity of AQP4 antibodies.
Keywords
Neuromyelitis Optica, Anti-AQP4, Antibodies
To cite this article
Marcellin Bugeme, Kegnide Cadnelle Christelle Affognon, Kouda Daniel Asta, Salahedine Mourabit, Olivier Mukuku, Neuromyelitis Optica with Negative Anti-Aquaporin-4 Antibodies: About an Observation, Clinical Neurology and Neuroscience. Vol. 1, No. 4, 2017, pp. 104-106. doi: 10.11648/j.cnn.20170104.15
Copyright
Copyright © 2017 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Daouda MT, Obenda NS, Assadeck H, Camara D, Djibo FH. Traitement de la neuromyélite optique de Devic durant de la grossesse. The Pan African Medical Journal 2016; 24.
[2]
Boulefkhad A, Taghane N, Hamri M. Neuromyélite optique de Devic (NMO): analyse clinique, radiologique et profil évolutif. Revue Neurologique 2013; 169: A153.
[3]
Marignier R, Bernard-Valnet R, Giraudon P, Collongues N, Papeix C, Zéphir H, et al. Aquaporin-4 antibody–negative neuromyelitis optica Distinct assay sensitivity–dependent entity. Neurology 2013; 80 (24): 2194-2200.
[4]
Barateau L, Papillon G, Olivier N, Cisse B, Fadat B, Gaillard N, Mas J. Neuromyélite optique à AC AQP4/NMO-IGG négatif: à propos de 3 observations. Revue Neurologique 2012; 168, A135.
[5]
Weinshenker BG. Neuromyelitis optica: what it is and what it might be. Lancet. 2003; 361 (9361): 889–90.
[6]
Papeix C. La maladie de Devic en quelques points. La Lettre du neurologue 2007; 11 (2): 50-52.
[7]
Bourmatte S, Boulefkhad A, Sifi Y, Taghane N, Hamri A. Neuromyélite optique de Devic: à propos de 15 cas. Revue Neurologique 2016; 172: A32.
[8]
Wingerchuk DM, Banwell B, Bennett JL, Cabre P, Carroll W, Chitnis T, et al. International consensus diagnostic criteria for neuromyelitis optica spectrum disorders. Neurology 2015; 85 (2): 177-189.
[9]
Cabre P, Gonzalez-Quevedo A, Lannuzel A, Bonnan M, Merle H, Olindo S, et al. Épidemiologie descriptive de la neuromyélite optique dans le bassin caraibéen. Revue neurologique 2009; 165 (8): 676-683.
[10]
Papeix C. Maladie de Devic. Presse Méd. 2006; 35: 1703-6.
[11]
Bouzidi N, Turki E, Dammak M, Mhiri C. Formes atypiques de neuro-myélite optique. Feuillets de Radiologie 2015; 55 (4): 231-235.
[12]
Bencherif MZ, Karib H, Tachfouti S, Guedira K, Mohcine Z. Neuromyélite optique de Devic chez l'enfant. Journal Français d'Ophtalmologie 2000; 23 (5): 488.
[13]
Déral-Stéphant V, Roux-Lelièvre C, Vignal R, Stéphant E, Faivre A, Alla P. Neuromyélite optique de Devic: discussion diagnostique après dix ans d’évolution d’une neuropathie optique bilatérale sévère. Journal Francais d'Ophtalmologie 2008; 31 (7): 705-709.
[14]
Bonnan M, Brasme H, Diaby MM, Vlaicu M, Le Guern V, Zuber M. Poussées sévères de neuromyélite optique: efficacité spectaculaire des échanges plasmatiques. Revue Neurologique 2009; 165 (5): 479-481.
[15]
Mandler RN. Neuromyelitis optica—Devic's syndrome, update. Autoimmunity reviews 2006; 5 (8): 537-543.
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