Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats
Clinical Neurology and Neuroscience
Volume 1, Issue 3, August 2017, Pages: 60-66
Received: Mar. 29, 2017; Accepted: Apr. 13, 2017; Published: May 26, 2017
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Mohammad Kazemzadeh, International Campus, Hamadan University of Medical Sciences, Hamadan, Iran
Parichehr Yaghmaei, Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Saeed Mohammadi, Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran
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Tanacetum balsamita is one of the important medicinal plants that is used by iranianan folk medicines. This study aimed to assess the phytochemical Screening, analgesic and anti-inflammatory effects of Tanacetum balsamita essential oil in rats. The essential oil of Tanacetum balsamita (EOTB) was treatment in doses of 10, 50, and 100 mg/kg. In addition, anti-nociceptive activity of EOTB was evaluated by formalin, writhing, and tail-flick tests. The EOTB was also combined with 2 mg/kg naloxone to determine the involvement of opioid mechanism. Anti-inflammatory reaction was evaluated via xylene-induced ear edema. In addition, the EOTB origin has been analyzed by a combination of GC and GC/MS. The EOTB at doses of 10-100 mg/kg have been shown significant analgesic effects (P<0.05). In compare of standard opioid agonist drug (morphine) and non-steroidal anti-inflammatory drug (indomethacine), Use of naloxone plus EOTB has been inhibited pain in all three models. The present results have been shown significant (P<0.05) anti-inflammatory effect of EOTB in the xylene-induced ear edema test in compare to dexamethasone. The major components in the tested oils were mainly contained quercetin, Isoquercitrin and luteolin. In conclusion, findings propose that EOTB probably have analgesic and anti-inflammatory effects. Existent of quercetin may be an important reason for mentioned effects.
Pain, Inflammation, Medicinal Plant, Tanacetum balsamita, Quercetin
To cite this article
Mohammad Kazemzadeh, Parichehr Yaghmaei, Saeed Mohammadi, Analgesic and Anti-inflammatory Effects of Tanacetum balsamita Essential Oil and One of Its Major Constituents (Quercetin) in Male Rats, Clinical Neurology and Neuroscience. Vol. 1, No. 3, 2017, pp. 60-66. doi: 10.11648/j.cnn.20170103.13
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