International Journal of Biomedical Science and Engineering

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Brillantasia patula Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats

Received: 27 May 2018    Accepted: 26 June 2018    Published: 24 July 2018
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Abstract

The protective effects of aqueous leaf extract of Brillantasia patula against hyperglycermia, lipid peroxidation, and alterations in hematological parameters in diabetic Wistar rats were investigated. The study consisted of six treatment groups, with five animals each, designated as Group-1 (healthy), Group-2 (diabetic control) and Groups 3-6 (diabetic rats treated with 500, 1000, 1500, and 2000 mg/kgbwt of extract, respectively). Rats were administered their respective doses orally, and daily, for 14 days. Thereafter, the effects on serum glucose levels, liver and kidney functions, lipid peroxidation, free radical scavenger and hematological parameters were analyzed. Blood glucose levels reduced markedly in diabetic rats given the plant extract relative to diabetic control. Both serum creatinine and urea decreased significantly in treated diabetic rats at extract doses of 1000 mg/kgbwt and above. Reductions in serum cholesterol (p<0.05) and triglyceride levels (p<0.05) were also observed. Elevated total serum protein and globulin in diabetic control was decreased in all treated groups. Haematological indices of groups given the extract were noticeably enhanced. Similarly, kidney, heart and liver glutathione (GSH) levels increased significantly in groups treated compared to diabetic control; lipid peroxidation in kidney and heart also decreased significantly in all the treated groups. Liver catalase activity improved. Serum alanine and aspartate aminotransferases activities widely lowered in Groups 3 and 4. The study indicates that Brillantaisia patula aqueous leaf extract exhibits potential hypoglycemic effect, prevents lipid peroxidation, boosts haematological parameters, and could protect liver and renal damage associated with diabetes especially at doses of 500 - 1000 mg/kgbwt.

DOI 10.11648/j.ijbse.20180602.14
Published in International Journal of Biomedical Science and Engineering (Volume 6, Issue 2, June 2018)
Page(s) 43-51
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Diabetes Mellitus, Brillantasia patula, Hypoglycemic Effect, Lipid Peroxidation, Antioxidants, Haematological Indices

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Author Information
  • Department of Biochemistry, Faculty of Science, Delta State University, Abraka, Nigeria

  • Biochemistry Division, Department of Chemical Sciences, College of Natural Sciences, Redeemer’s University, Ede, Nigeria

  • Department of Biochemistry, Faculty of Science, Delta State University, Abraka, Nigeria

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    Akpovwehwee Akporhuarho Anigboro, Oghenetega Jonathan Avwioroko, Nyerhovwo John Tonukari. (2018). Brillantasia patula Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats. International Journal of Biomedical Science and Engineering, 6(2), 43-51. https://doi.org/10.11648/j.ijbse.20180602.14

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    ACS Style

    Akpovwehwee Akporhuarho Anigboro; Oghenetega Jonathan Avwioroko; Nyerhovwo John Tonukari. Brillantasia patula Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats. Int. J. Biomed. Sci. Eng. 2018, 6(2), 43-51. doi: 10.11648/j.ijbse.20180602.14

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    AMA Style

    Akpovwehwee Akporhuarho Anigboro, Oghenetega Jonathan Avwioroko, Nyerhovwo John Tonukari. Brillantasia patula Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats. Int J Biomed Sci Eng. 2018;6(2):43-51. doi: 10.11648/j.ijbse.20180602.14

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  • @article{10.11648/j.ijbse.20180602.14,
      author = {Akpovwehwee Akporhuarho Anigboro and Oghenetega Jonathan Avwioroko and Nyerhovwo John Tonukari},
      title = {Brillantasia patula Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats},
      journal = {International Journal of Biomedical Science and Engineering},
      volume = {6},
      number = {2},
      pages = {43-51},
      doi = {10.11648/j.ijbse.20180602.14},
      url = {https://doi.org/10.11648/j.ijbse.20180602.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ijbse.20180602.14},
      abstract = {The protective effects of aqueous leaf extract of Brillantasia patula against hyperglycermia, lipid peroxidation, and alterations in hematological parameters in diabetic Wistar rats were investigated. The study consisted of six treatment groups, with five animals each, designated as Group-1 (healthy), Group-2 (diabetic control) and Groups 3-6 (diabetic rats treated with 500, 1000, 1500, and 2000 mg/kgbwt of extract, respectively). Rats were administered their respective doses orally, and daily, for 14 days. Thereafter, the effects on serum glucose levels, liver and kidney functions, lipid peroxidation, free radical scavenger and hematological parameters were analyzed. Blood glucose levels reduced markedly in diabetic rats given the plant extract relative to diabetic control. Both serum creatinine and urea decreased significantly in treated diabetic rats at extract doses of 1000 mg/kgbwt and above. Reductions in serum cholesterol (pBrillantaisia patula aqueous leaf extract exhibits potential hypoglycemic effect, prevents lipid peroxidation, boosts haematological parameters, and could protect liver and renal damage associated with diabetes especially at doses of 500 - 1000 mg/kgbwt.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Brillantasia patula Aqueous Leaf Extract Averts Hyperglycermia, Lipid Peroxidation, and Alterations in Hematological Parameters in Alloxan-Induced Diabetic Rats
    AU  - Akpovwehwee Akporhuarho Anigboro
    AU  - Oghenetega Jonathan Avwioroko
    AU  - Nyerhovwo John Tonukari
    Y1  - 2018/07/24
    PY  - 2018
    N1  - https://doi.org/10.11648/j.ijbse.20180602.14
    DO  - 10.11648/j.ijbse.20180602.14
    T2  - International Journal of Biomedical Science and Engineering
    JF  - International Journal of Biomedical Science and Engineering
    JO  - International Journal of Biomedical Science and Engineering
    SP  - 43
    EP  - 51
    PB  - Science Publishing Group
    SN  - 2376-7235
    UR  - https://doi.org/10.11648/j.ijbse.20180602.14
    AB  - The protective effects of aqueous leaf extract of Brillantasia patula against hyperglycermia, lipid peroxidation, and alterations in hematological parameters in diabetic Wistar rats were investigated. The study consisted of six treatment groups, with five animals each, designated as Group-1 (healthy), Group-2 (diabetic control) and Groups 3-6 (diabetic rats treated with 500, 1000, 1500, and 2000 mg/kgbwt of extract, respectively). Rats were administered their respective doses orally, and daily, for 14 days. Thereafter, the effects on serum glucose levels, liver and kidney functions, lipid peroxidation, free radical scavenger and hematological parameters were analyzed. Blood glucose levels reduced markedly in diabetic rats given the plant extract relative to diabetic control. Both serum creatinine and urea decreased significantly in treated diabetic rats at extract doses of 1000 mg/kgbwt and above. Reductions in serum cholesterol (pBrillantaisia patula aqueous leaf extract exhibits potential hypoglycemic effect, prevents lipid peroxidation, boosts haematological parameters, and could protect liver and renal damage associated with diabetes especially at doses of 500 - 1000 mg/kgbwt.
    VL  - 6
    IS  - 2
    ER  - 

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