Background: The genital infection due to Human papillomavirus (HPV) is considered as the most common sexually transmitted infection across the world, including high-risk oncogenic HPV (HR/HPV). Objective: This study aimed to determine the prevalence of HR/HPV genotypes among sexually active women in Parakou (Benin) in 2017. Methods: This research work was a cross-sectional descriptive study carried out in the city of Parakou (Benin), from January 15 to April 15, 2017. Sample consisted of 247 sexually active women selected through a systematic random sampling. Cervical specimens collected with swab were subject to multiplex PCR to characterize 14 HR/HPV genotypes. Results: The prevalence of HR/HPV infection was rated 32.8% [95% CI: 27.1-39.3]. All the fourteen HR/HPV genotypes investigated were detected using PCR among our study population. The most common types of HR/HPV were, in descending order, HPV45 (25.9%), HPV35 (18.5%), HPV52 (17.3%), HPV51 (16.0%) and HPV58 (14.8%). HPV16 and 18 were found out at respective proportions of 2.5% and 7.4%. Age group 20 years or less had the highest prevalence of HR/HPV infection (55.7%) followed by age group from 21 to 30 years (38.3%). Conclusion: The prevalence of HR/HPV infection is high among sexually active women in Parakou in 2017 and the most frequent HR/HPV are not those found commonly in precancerous and cancerous cervical lesions.
| Published in | Journal of Gynecology and Obstetrics (Volume 8, Issue 4) |
| DOI | 10.11648/j.jgo.20200804.16 |
| Page(s) | 102-107 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2024. Published by Science Publishing Group |
High-Risk HPV, Prevalence, Real Time PCR, Women, Benin
| [1] | Shi R, Devarakonda S, Liu L, Taylor H, Mills G. Factors associated with genital human papillomavirus infection among adult females in the United States, NHANES 2007–2010. BMC Res Notes. 2014; 7: 544. DOI: 10.1186/1756-0500-7-544. |
| [2] | Shaw E, Ramanakumar AV, El-Zein M, Silva FR, Galan L, Baggio ML et al. Reproductive and genital health and risk of cervical human papillomavirus infection: results from the Ludwig-McGill cohort study. BMC Infect. Dis. 2016; 16: 116. DOI: 10.1186/s12879-016-1446-x. |
| [3] | Graham SV. Human papillomavirus: gene expression, regulation and prospects for novel diagnostic methods and antiviral therapies. Future Microbiol. 2010; 5 (10): 1493-1506. DOI: 10.2217/fmb.10.107. |
| [4] | Schiffman M, Doorbar J, Wentzensen N, de Sanjosé S, Fakhry C, Monk BJ et al. Carcinogenic human papillomavirus infection. Nature Reviews Disease Primers. 2016; 2. https://doi.org/10.1038/nrdp.2016.86. |
| [5] | Rodriguez-Cerdeira C, Sanchez-Blanco E, Alba A. Evaluation of Association between Vaginal Infections and High-Risk Human Papillomavirus Types in Female Sex Workers in Spain. ISRN Obstetrics and Gynecology. 2012. Article ID 240190. DOI: 10.5402/2012/240190. |
| [6] | Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA: Cancer J Clin. 2018; 68: 394-424. DOI: 10.3322/caac.21492. |
| [7] | Ronco G, Dillner J, Elfström KM, Tunesi S, Snijders PJF, Arbyn M et al. Efficacy of HPV-based screening for prevention of invasive cervical cancer: follow-up of four European randomised controlled trials. Lancet. 2014; 383 (9916): 524-532. DOI: 10.1016/S0140-6736(13)62218-7. |
| [8] | Sankaranarayanan R. HPV vaccination: the most pragmatic cervical cancer primary prevention strategy. Int J Gynaecol Obstet. 2015; 131 (suppl 1): S33-S35. DOI: 10.1016/j.ijgo.2015.02.014. |
| [9] | Quan Toh Z, Kosasih J, Russell FM, Garland SM, Mulholland EK, Licciardi PV. Recombinant Human Papillomavirus Nonavalent Vaccine in the Prevention of Cancers Caused by Human Papillomavirus. Infect Drug Resist. 2019; 12: 1951-1967. DOI: 10.2147/IDR.S178381. |
| [10] | Zohoncon TM, Bisseye C, Djigma FW, Yonli AT, Compaore TR, Sagna T et al. Prevalence of HPV High-Risk Genotypes in Three Cohorts of Women in Ouagadougou (Burkina Faso). Mediterr J Hematol Infect Dis. 2013; 5 (1): e2013059. DOI: 10.4084/MJHID.2013.059. |
| [11] | Traore IMA, Zohoncon TM, Dembele A, Djigma FW, Obiri-Yeboah D, Traore G et al. Molecular Characterization of High-Risk Human Papillomavirus in Women in Bobo-Dioulasso, Burkina Faso. Biomed Res Int. 2016. Article ID 7092583. DOI: 10.1155/2016/7092583. |
| [12] | Ouedraogo RA, Zohoncon TM, Guigma SP, Traore IMA, Ouattara AK, Ouedraogo M et al. Oncogenic human papillomavirus infection and genotypes characterization among sexually active women in Tenkodogo at Burkina Faso, West Africa. Papillomavirus Research. 2018; 6: 22-26. DOI: 10.1016/j.pvr.2018.09.001. |
| [13] | Jaquet A, Horo A, Charbonneau V, Ekouevi DK, Roncin L, Toure B et al. Cervical human papillomavirus and HIV infection in women of child-bearing age in Abidjan, Côte d’Ivoire. Br J Cancer. 2010; 107 (3): 556-563. DOI: 10.1038/bjc.2012.299. |
| [14] | Ndiaye C, Alemany L, Ndiaye N, Kamate B, Diop Y, Odida M et al. Human papillomavirus distribution in invasive cervical carcinoma in sub-Saharan Africa: could HIV explain the differences? Trop Med Int Health. 2012; 17 (12): 1432-1440. DOI: 10.1111/tmi.12004. |
| [15] | Manga MM, Fowotade A, Abdullahi YM, El-nafaty AU, Adamu DB, Pindiga HU et al. Epidemiological patterns of cervical human papillomavirus infection among women presenting for cervical cancer screening in North-Eastern Nigeria. Infectious Agents and Cancer. 2015; 10: 39. DOI 10.1186/s13027-015-0035-8. |
| [16] | Piras F, Piga M, De Montis A, Zannou ARF, Minerba L, Perra MT et al. Prevalence of human papillomavirus infection in women in Benin, West Africa. Virol J. 2011; 8: 514. DOI: 10.1186/1743-422X-8-514. |
| [17] | Zohoncon TM, Ouédraogo TC, Brun LVC, Obiri-Yeboah D, Djigma WF, Salifou K et al. Molecular Epidemiology of High-Risk Human Papillomavirus in High-Grade Cervical Intraepithelial Neoplasia and in Cervical Cancer in Parakou, Republic of Benin. Pak. J. Biol. Sci. 2016; 19: 49-56. DOI: 10.3923/pjbs.2016. |
| [18] | Winer RL, Hughes JP, Feng Q, Fu Xi L, Lee SK, O’Reilly SF et al. Prevalence and risk factors for oncogenic HPV infections in high-risk mid-adult women. Sex Transm Dis. 2012; 39 (11): 848-856. DOI: 10.1097/OLQ.0b013e3182641f1c. |
| [19] | Andall-Brereton G, Brown E, Slater S, Holder Y, Luciani S, Lewis M et al. Prevalence of high-risk human papillomavirus among women in two English-speaking Caribbean countries. Rev Panam Salud Publica. 2017; e41: e41. |
| [20] | Navarro-Vidal E, Hernandez-Rosas F, Rey M, Flores-Peredo L. Prevalence of Human Papillomavirus Genotypes in Women from Cozumel, Mexico. Asian Pac J Cancer Prev. 2018; 19 (9): 2417-2422. DOI: 10.22034/APJCP.2018.19.9.2417. |
| [21] | Schluterman NH, Sow SO, Traore CB, Bakarou K, Dembelé R, Sacko F et al. Differences in patterns of high-risk Human papillomavirus infection between urban and rural low-resource settings: cross-sectional findings from Mali. BMC Womens Health. 2013; 13: 4. DOI: 10.1186/1472-6874-13-4. |
| [22] | Wang J, Tang D, Wang K, Wang J, Zhang Z, Chen Y et al. HPV genotype prevalence and distribution during 2009–2018 in Xinjiang, China: baseline surveys prior to mass HPV vaccination. BMC Women's Health. 2019; 19: 90. DOI: 10.1186/s12905-019-0785-3. |
| [23] | de Sanjose S, Quint WGV, Alemany L, Geraets DT, Klaustermeier JE, Lloveras B et al. Human papillomavirus genotype attribution in invasive cervical cancer: a retrospective cross-sectional worldwide study. Lancet Oncol. 2010; 11: 1048-1056. DOI: 10.1016/S1470-2045(10)70230-8. |
| [24] | Clifford GM, Goncalves MA, Franceschi S. Human papillomavirus types among women infected with HIV: a meta-analysis. AIDS 2006; 20 (18): 2337-2344. DOI: 10.1097/01.aids.0000253361.63578.14. |
| [25] | Panatto D, Amicizia D, Tanzi E, Bianchi S, Frati ER, Zotti CM et al. Prevalence of human papillomavirus in young Italian women with normal cytology: how should we adapt the national vaccination policy? BMC Infect. Dis. 2013; 13: 575. DOI: 10.1186/1471-2334-13-575. |
| [26] | Guettiti H, Ennaifer E, Attia L, Chelly D, Alaya NB, Aissa RB et al. Pre-vaccination prevalence and genotype distribution of human papillomavirus infection among women from urban Tunis: a cross-sectional study. Asian Pac. J. Cancer Prev. 2014; 15 (21): 9361-9365. DOI: 10.7314/apjcp.2014.15.21.9361. |
| [27] | Monsonego J, Cox JT, Behrens C, Sandri M, Franco EL, Yap PS et al. Prevalence of high-risk human papilloma virus genotypes and associated risk of cervical precancerous lesions in a large U.S. screening population: data from the ATHENA trial. Gynecol. Oncol. 2015; 137 (1): 47-54. DOI: 10.1016/j.ygyno.2015.01.551. |
| [28] | Zhao XL, Hu SY, Zhang Q, Dong L, Feng RM, Han R et al. High-risk human papillomavirus genotype distribution and attribution to cervical cancer and precancerous lesions in a rural Chinese population. J Gynecol Oncol. 2017; 28 (4): e30. DOI: 10.3802/jgo.2017.28.e30. |
| [29] | Zhu C, Wang Y, Mao W, Zhang H, Ma J. Prevalence and distribution of HPV types in genital warts in Xi'an, China: a prospective study. BMJ Open. 2019; 9: e023897. DOI: 10.1136/bmjopen-2018-023897. |
| [30] | Kavanagh K, Sinka K, Cuschieri K, Love J, Potts A, Pollock KG et al. Estimation of HPV prevalence in young women in Scotland; monitoring of future vaccine impact. BMC Infect. Dis. 2013; 13: 519. DOI: 10.1186/1471-2334-13-519. |
| [31] | Dareng EO, Adebamowo SN, Famooto A, Olawande O, Odutola MK, Olaniyan Y et al. Prevalence and incidence of genital warts and cervical Human Papillomavirus infections in Nigerian women. BMC Infect. Dis. 2019; 19: 27. DOI: 10.1186/s12879-018-3582-y. |
APA Style
Christianne Gandekon, Rachidi Sidi Imorou, Théodora Zohoncon, Moutawakilou Gomina, Alice Ouedraogo, et al. (2020). Prevalence of Oncogenic Human Papillomavirus Genotypes Among Sexually Active Women in Parakou (Benin, West Africa). Journal of Gynecology and Obstetrics, 8(4), 102-107. https://doi.org/10.11648/j.jgo.20200804.16
ACS Style
Christianne Gandekon; Rachidi Sidi Imorou; Théodora Zohoncon; Moutawakilou Gomina; Alice Ouedraogo, et al. Prevalence of Oncogenic Human Papillomavirus Genotypes Among Sexually Active Women in Parakou (Benin, West Africa). J. Gynecol. Obstet. 2020, 8(4), 102-107. doi: 10.11648/j.jgo.20200804.16
AMA Style
Christianne Gandekon, Rachidi Sidi Imorou, Théodora Zohoncon, Moutawakilou Gomina, Alice Ouedraogo, et al. Prevalence of Oncogenic Human Papillomavirus Genotypes Among Sexually Active Women in Parakou (Benin, West Africa). J Gynecol Obstet. 2020;8(4):102-107. doi: 10.11648/j.jgo.20200804.16
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Download@article{10.11648/j.jgo.20200804.16,
author = {Christianne Gandekon and Rachidi Sidi Imorou and Théodora Zohoncon and Moutawakilou Gomina and Alice Ouedraogo and Ina Traore and Essolokina Dolou and Prosper Bado and Esther Traore and Charlemagne Ouedraogo and Jacques Simpore and Simon Akpona},
title = {Prevalence of Oncogenic Human Papillomavirus Genotypes Among Sexually Active Women in Parakou (Benin, West Africa)},
journal = {Journal of Gynecology and Obstetrics},
volume = {8},
number = {4},
pages = {102-107},
doi = {10.11648/j.jgo.20200804.16},
url = {https://doi.org/10.11648/j.jgo.20200804.16},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20200804.16},
abstract = {Background: The genital infection due to Human papillomavirus (HPV) is considered as the most common sexually transmitted infection across the world, including high-risk oncogenic HPV (HR/HPV). Objective: This study aimed to determine the prevalence of HR/HPV genotypes among sexually active women in Parakou (Benin) in 2017. Methods: This research work was a cross-sectional descriptive study carried out in the city of Parakou (Benin), from January 15 to April 15, 2017. Sample consisted of 247 sexually active women selected through a systematic random sampling. Cervical specimens collected with swab were subject to multiplex PCR to characterize 14 HR/HPV genotypes. Results: The prevalence of HR/HPV infection was rated 32.8% [95% CI: 27.1-39.3]. All the fourteen HR/HPV genotypes investigated were detected using PCR among our study population. The most common types of HR/HPV were, in descending order, HPV45 (25.9%), HPV35 (18.5%), HPV52 (17.3%), HPV51 (16.0%) and HPV58 (14.8%). HPV16 and 18 were found out at respective proportions of 2.5% and 7.4%. Age group 20 years or less had the highest prevalence of HR/HPV infection (55.7%) followed by age group from 21 to 30 years (38.3%). Conclusion: The prevalence of HR/HPV infection is high among sexually active women in Parakou in 2017 and the most frequent HR/HPV are not those found commonly in precancerous and cancerous cervical lesions.},
year = {2020}
}
TY - JOUR T1 - Prevalence of Oncogenic Human Papillomavirus Genotypes Among Sexually Active Women in Parakou (Benin, West Africa) AU - Christianne Gandekon AU - Rachidi Sidi Imorou AU - Théodora Zohoncon AU - Moutawakilou Gomina AU - Alice Ouedraogo AU - Ina Traore AU - Essolokina Dolou AU - Prosper Bado AU - Esther Traore AU - Charlemagne Ouedraogo AU - Jacques Simpore AU - Simon Akpona Y1 - 2020/07/28 PY - 2020 N1 - https://doi.org/10.11648/j.jgo.20200804.16 DO - 10.11648/j.jgo.20200804.16 T2 - Journal of Gynecology and Obstetrics JF - Journal of Gynecology and Obstetrics JO - Journal of Gynecology and Obstetrics SP - 102 EP - 107 PB - Science Publishing Group SN - 2376-7820 UR - https://doi.org/10.11648/j.jgo.20200804.16 AB - Background: The genital infection due to Human papillomavirus (HPV) is considered as the most common sexually transmitted infection across the world, including high-risk oncogenic HPV (HR/HPV). Objective: This study aimed to determine the prevalence of HR/HPV genotypes among sexually active women in Parakou (Benin) in 2017. Methods: This research work was a cross-sectional descriptive study carried out in the city of Parakou (Benin), from January 15 to April 15, 2017. Sample consisted of 247 sexually active women selected through a systematic random sampling. Cervical specimens collected with swab were subject to multiplex PCR to characterize 14 HR/HPV genotypes. Results: The prevalence of HR/HPV infection was rated 32.8% [95% CI: 27.1-39.3]. All the fourteen HR/HPV genotypes investigated were detected using PCR among our study population. The most common types of HR/HPV were, in descending order, HPV45 (25.9%), HPV35 (18.5%), HPV52 (17.3%), HPV51 (16.0%) and HPV58 (14.8%). HPV16 and 18 were found out at respective proportions of 2.5% and 7.4%. Age group 20 years or less had the highest prevalence of HR/HPV infection (55.7%) followed by age group from 21 to 30 years (38.3%). Conclusion: The prevalence of HR/HPV infection is high among sexually active women in Parakou in 2017 and the most frequent HR/HPV are not those found commonly in precancerous and cancerous cervical lesions. VL - 8 IS - 4 ER -
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