Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report

Herrera-Ortiz Alejandra; Barrita-Domínguez Isela Juliana; Morales-Domínguez Liliana; Rojas-Camacho Francisco Miguel

doi:doi:10.11648/j.jgo.20190702.12

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Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report

Herrera-Ortiz Alejandra, Barrita-Domínguez Isela Juliana, Morales-Domínguez Liliana, Rojas-Camacho Francisco Miguel

Received: 23 January 2019 Accepted: 30 March 2019 Published: 22 April 2019

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Abstract

Background: Gestational trophoblastic disease (GTD) is the consequence of a genetic alteration that happens during fecundation. Is the term used to describe malignant lesions that originates in the chorionic villi an extra villous trophoblast. Molar pregnancies can be subdivided into complete (CM) and partial moles (PM) based on genetic and histopathological features. Case report: 23-year old patient, who presents an ultrasound which revealed a singleton pregnancy with no fetal structural abnormalities, and fetal biometry consistent with gestational age (16w + 6d). There was a placenta with focal areas of enlargement associated with numerous lucent cyst, and normal amniotic fluid, compatible with partial molar pregnancy in association with a normal fetus. After risks of subsequent fetal and maternal complications were explained to the patient and her family, it was elected to continue with her pregnancy; patient went under cesarean delivery at 31w 3d because low amniotic fluid levels (oligohydramnios) and abnormal fetal well-being tests.

DOI	10.11648/j.jgo.20190702.12
Published in	Journal of Gynecology and Obstetrics (Volume 7, Issue 2, March 2019)
Page(s)	36-40
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Gestational Trophoblastic Disease, Partial Mole, Partial Mole Associated with Normal Fetus

References

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[2]	Hui P, Buza N, Murphy KM, Ronnett BM. Hydatidiform Moles: Genetic Basis and Precision Diagnosis. Annu Rev Pathol. 2017 Jan 24;12:449-485.
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[5]	Surendran S, Thomas T, Vishnupriya VS. Partial Molar Pregnancy with a Normal Fetus with Complete Placenta Previa. J Obstet Gynaecol India 2018 Jun; 68(3):227.228.
[6]	Galaz-Montoya CI, Razo Aguilera G, Grether-González P, Aguinaga-Ríos M. Aspectos genéticos de la mola hidatiforme. Perinatol Reprodu Hum 2015; 29(3): 113-117
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[8]	Morales García V, Bautista Gómez E, Vásquez Santiago E, Santos Pérez U. Embarazo molar parcial: reporte de un caso y revisión de la bibliografía. Ginecol Obstet Mex 2011;79(7):432-435.
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[10]	Sak ME, Soydinc HE, Evsen MS, Firat U. Diploide karyotype partial mole coexisting with live term fetus-case report and reviewd of the world literature. Ginekol Pol. 2012 Oct;83(10):789-91
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[12]	Kawasaki K, Kondoh E, Minamiguchi S, Matsuda F, Higasa K, Fujita K, Mogami H, Chigusa Y, Konishi I. Live-born diploid fetus complicated with partial molar pregnancy presenting with pre-eclampsia, maternal anemia, and seemingly huge placenta: A rare case of confined placental mosaicism and literatura review. J Obstet Gynaecol Res. 2016 Aug;42(8):911-7.
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[14]	Rahamni M, Parviz S. A case report of partial molar pregnancy associated with a normal appearing dizygotic fetus. Asian Pacific Journal of Reproduction 2016; 5(2): 171.173.
[15]	Ramani B et al. Living fetus without congenital malformation in a singleton partial hydatiform molar pregnancy: a case report and review of the literature. In J Reprod Contracept Obstet Gynecol. 2014 Dec: 3(4): 1130-1133.
[16]	Tizita A. Partial mole with coexisting term fetus. A case report. Ethiopian Journal of Reproductive Health 2018; 10 (2): 53-56.
[17]	Deever R, Engin- Üstün Y, Gün-Erylmaz Ö, Akbaba E, et al. Molar Pregnancy with a Co-Existing Viable Fetus. J Clin Anal Med 2015; 6(1): 88-90.
[18]	Makrydimas G, Serbire NJ, Thornton SE, Zagorianakou N, Lolis D, Fisher RA. Complete hydatidiform mole and normal live birth: a novel case of confined placental mosaicism: case report. Hum Reprod. 2002 Sep;17(9):2459-63.
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APA Style

Herrera-Ortiz Alejandra, Barrita-Domínguez Isela Juliana, Morales-Domínguez Liliana, Rojas-Camacho Francisco Miguel. (2019). Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report. Journal of Gynecology and Obstetrics, 7(2), 36-40. https://doi.org/10.11648/j.jgo.20190702.12

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ACS Style

Herrera-Ortiz Alejandra; Barrita-Domínguez Isela Juliana; Morales-Domínguez Liliana; Rojas-Camacho Francisco Miguel. Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report. J. Gynecol. Obstet. 2019, 7(2), 36-40. doi: 10.11648/j.jgo.20190702.12

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AMA Style

Herrera-Ortiz Alejandra, Barrita-Domínguez Isela Juliana, Morales-Domínguez Liliana, Rojas-Camacho Francisco Miguel. Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report. J Gynecol Obstet. 2019;7(2):36-40. doi: 10.11648/j.jgo.20190702.12

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@article{10.11648/j.jgo.20190702.12,
  author = {Herrera-Ortiz Alejandra and Barrita-Domínguez Isela Juliana and Morales-Domínguez Liliana and Rojas-Camacho Francisco Miguel},
  title = {Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {7},
  number = {2},
  pages = {36-40},
  doi = {10.11648/j.jgo.20190702.12},
  url = {https://doi.org/10.11648/j.jgo.20190702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190702.12},
  abstract = {Background: Gestational trophoblastic disease (GTD) is the consequence of a genetic alteration that happens during fecundation. Is the term used to describe malignant lesions that originates in the chorionic villi an extra villous trophoblast. Molar pregnancies can be subdivided into complete (CM) and partial moles (PM) based on genetic and histopathological features. Case report: 23-year old patient, who presents an ultrasound which revealed a singleton pregnancy with no fetal structural abnormalities, and fetal biometry consistent with gestational age (16w + 6d). There was a placenta with focal areas of enlargement associated with numerous lucent cyst, and normal amniotic fluid, compatible with partial molar pregnancy in association with a normal fetus. After risks of subsequent fetal and maternal complications were explained to the patient and her family, it was elected to continue with her pregnancy; patient went under cesarean delivery at 31w 3d because low amniotic fluid levels (oligohydramnios) and abnormal fetal well-being tests.},
 year = {2019}
}

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TY  - JOUR
T1  - Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report
AU  - Herrera-Ortiz Alejandra
AU  - Barrita-Domínguez Isela Juliana
AU  - Morales-Domínguez Liliana
AU  - Rojas-Camacho Francisco Miguel
Y1  - 2019/04/22
PY  - 2019
N1  - https://doi.org/10.11648/j.jgo.20190702.12
DO  - 10.11648/j.jgo.20190702.12
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 36
EP  - 40
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20190702.12
AB  - Background: Gestational trophoblastic disease (GTD) is the consequence of a genetic alteration that happens during fecundation. Is the term used to describe malignant lesions that originates in the chorionic villi an extra villous trophoblast. Molar pregnancies can be subdivided into complete (CM) and partial moles (PM) based on genetic and histopathological features. Case report: 23-year old patient, who presents an ultrasound which revealed a singleton pregnancy with no fetal structural abnormalities, and fetal biometry consistent with gestational age (16w + 6d). There was a placenta with focal areas of enlargement associated with numerous lucent cyst, and normal amniotic fluid, compatible with partial molar pregnancy in association with a normal fetus. After risks of subsequent fetal and maternal complications were explained to the patient and her family, it was elected to continue with her pregnancy; patient went under cesarean delivery at 31w 3d because low amniotic fluid levels (oligohydramnios) and abnormal fetal well-being tests.
VL  - 7
IS  - 2
ER  -

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Author Information

Herrera-Ortiz Alejandra

Department of Gynecology and Obstetrics at General Hospital “Dr. Manuel Gea González”, México City, Mexico
Barrita-Domínguez Isela Juliana

Department of Maternal-Fetal Medicine at General Hospital “Dr. Manuel Gea González”, México City, Mexico
Morales-Domínguez Liliana

Department of Hysteroscopy at General Hospital “Dr. Manuel Gea González”, México City, Mexico
Rojas-Camacho Francisco Miguel

Department of Gynecology and Obstetrics at General Hospital “Dr. Manuel Gea González”, México City, Mexico

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APA Style

Herrera-Ortiz Alejandra, Barrita-Domínguez Isela Juliana, Morales-Domínguez Liliana, Rojas-Camacho Francisco Miguel. (2019). Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report. Journal of Gynecology and Obstetrics, 7(2), 36-40. https://doi.org/10.11648/j.jgo.20190702.12

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ACS Style

Herrera-Ortiz Alejandra; Barrita-Domínguez Isela Juliana; Morales-Domínguez Liliana; Rojas-Camacho Francisco Miguel. Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report. J. Gynecol. Obstet. 2019, 7(2), 36-40. doi: 10.11648/j.jgo.20190702.12

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AMA Style

Herrera-Ortiz Alejandra, Barrita-Domínguez Isela Juliana, Morales-Domínguez Liliana, Rojas-Camacho Francisco Miguel. Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report. J Gynecol Obstet. 2019;7(2):36-40. doi: 10.11648/j.jgo.20190702.12

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@article{10.11648/j.jgo.20190702.12,
  author = {Herrera-Ortiz Alejandra and Barrita-Domínguez Isela Juliana and Morales-Domínguez Liliana and Rojas-Camacho Francisco Miguel},
  title = {Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {7},
  number = {2},
  pages = {36-40},
  doi = {10.11648/j.jgo.20190702.12},
  url = {https://doi.org/10.11648/j.jgo.20190702.12},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20190702.12},
  abstract = {Background: Gestational trophoblastic disease (GTD) is the consequence of a genetic alteration that happens during fecundation. Is the term used to describe malignant lesions that originates in the chorionic villi an extra villous trophoblast. Molar pregnancies can be subdivided into complete (CM) and partial moles (PM) based on genetic and histopathological features. Case report: 23-year old patient, who presents an ultrasound which revealed a singleton pregnancy with no fetal structural abnormalities, and fetal biometry consistent with gestational age (16w + 6d). There was a placenta with focal areas of enlargement associated with numerous lucent cyst, and normal amniotic fluid, compatible with partial molar pregnancy in association with a normal fetus. After risks of subsequent fetal and maternal complications were explained to the patient and her family, it was elected to continue with her pregnancy; patient went under cesarean delivery at 31w 3d because low amniotic fluid levels (oligohydramnios) and abnormal fetal well-being tests.},
 year = {2019}
}

Copy | Download

TY  - JOUR
T1  - Conservative Management, Follow-up and Perinatal Outcomes After Gestational Trophoblastic Disease with Coexistent Normal Fetus: Case Report
AU  - Herrera-Ortiz Alejandra
AU  - Barrita-Domínguez Isela Juliana
AU  - Morales-Domínguez Liliana
AU  - Rojas-Camacho Francisco Miguel
Y1  - 2019/04/22
PY  - 2019
N1  - https://doi.org/10.11648/j.jgo.20190702.12
DO  - 10.11648/j.jgo.20190702.12
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 36
EP  - 40
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20190702.12
AB  - Background: Gestational trophoblastic disease (GTD) is the consequence of a genetic alteration that happens during fecundation. Is the term used to describe malignant lesions that originates in the chorionic villi an extra villous trophoblast. Molar pregnancies can be subdivided into complete (CM) and partial moles (PM) based on genetic and histopathological features. Case report: 23-year old patient, who presents an ultrasound which revealed a singleton pregnancy with no fetal structural abnormalities, and fetal biometry consistent with gestational age (16w + 6d). There was a placenta with focal areas of enlargement associated with numerous lucent cyst, and normal amniotic fluid, compatible with partial molar pregnancy in association with a normal fetus. After risks of subsequent fetal and maternal complications were explained to the patient and her family, it was elected to continue with her pregnancy; patient went under cesarean delivery at 31w 3d because low amniotic fluid levels (oligohydramnios) and abnormal fetal well-being tests.
VL  - 7
IS  - 2
ER  -

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