Journal of Gynecology and Obstetrics

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Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis

Received: 05 December 2017    Accepted: 15 December 2017    Published: 16 January 2018
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Abstract

This study investigated the thiol-disulphide balance in vaginitis, which is a local inflammatory condition, through the use of a new method. A cross-sectional study involving 82 women (45 women with vaginitis and 37 women in control group) was conducted at Ataturk Education and Research Hospital, Ankara, Turkey from February 2016 to April 2016. Their ages varied between 19-75 years (mean: 42.8±11.6), were incorporated into the study. Thiol – disulphide parameters were measured and the obtained results were compared. The results showed that the serum disulphide level and disulphide/native thiol ratio in the group with vaginitis (p = 0.03 and p = 0.04) and the native thiol/total thiol ratio in the control group was higher (p = 0.03). In this study, it was shown that serum dynamic thiol-disulphide balance in the women with vaginitis had varied. Although vaginitis is a localized infectious inflammatory condition, the increase in the systemic oxidative stress is important. This study is the first article in the literature that investigates the relationship between dynamic thiol-disulphide balance and vaginitis.

DOI 10.11648/j.jgo.20180601.11
Published in Journal of Gynecology and Obstetrics (Volume 6, Issue 1, January 2018)
Page(s) 1-5
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Disulphide, Thiol, Vaginitis

References
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[2] Eschenbach DA, Davick PR, Williams BL, Klebanoff SJ, Young-Smith K, Critchlow CM, et al. Prevalence of hydrogen peroxide-producing Lactobacillus species in normal women and women with bacterial vaginosis. J Clin Microbiol 1989; 27 (2): 251-256.
[3] Biswas S, Chida AS, Rahman I. Redox modifications of protein–thiols: emerging roles in cell signaling. Biochem Pharmacol 2006; 71 (5): 551-564.
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[6] Dogru A, Balkarli A, Cetin GY, Neselioglu S, Erel O, Tunc SE. et al. 2016. Thiol/disulphide homeostasis in patients with ankylosing spondylitis. Bosnian Journal of Basic Medical Sciences 2016; Doi: http://dx.doi.org/10.17305/bjbms.2016.1001
[7] Yuksel M, Ates I, Kaplan M, Alisik M, Erel O, Saygili F et al. The dynamic thiol/disulphide homeostasis in inflammatory bowel disease and its relation with disease activity and pathogenesis. Int J Colorectal Dis 2016; 31 (6): 1229-1231.
[8] Kara SS, Erel O, Demirdag TB, Cura BC, Gulhan B, Neselioglu S et al. Alteration of thiol-disulphide homeostasis in acute tonsillopharyngitis. Redox Report 2016; DOI: 10.1080/13510002.2016.1173328
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[16] Kustimur S, Kalkanci A, Akbulut G, Gonul B, Bulduk E, Aksakal FN. et al. The effect of vaginal candidiasis on the levels of the oxidative biomarkers in plasma and tissue samples of diabetic rats. Mycopathologia 2007; 164 (5): 217-224.
[17] Ratti BA, Godoy JSR, Mendonca PSB, Bidoia DL, Nakamura TU, Consolaro MEL, et al. Microbicidal activity of neutrophils is inhibited by isolates from recurrent vaginal candidiasis (RVVC) caused by Candida albicans through fungal thioredoxin reductase. Cell. Immunol 2015; 293 (1): 22-29.
[18] Bogavac M, Lakic N, Simin N, Nikolic A, Sudji J, Bozin B. Bacterial vaginosis and biomarkers of oxidative stress in amniotic fluid. The Journal of Maternal-Fetal & Neonatal Medicine 2012; 25 (7): 1050-1054.
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Author Information
  • Obstetrics and Gynecology Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

  • Obstetrics and Gynecology Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

  • Biochemistry Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

  • Biochemistry Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

  • Obstetrics and Gynecology Department, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey

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  • APA Style

    Raziye Desdicioglu, Melahat Yildirim, Betul Ozbek, Gokhan Kılıc, Ozcan Erel, et al. (2018). Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis. Journal of Gynecology and Obstetrics, 6(1), 1-5. https://doi.org/10.11648/j.jgo.20180601.11

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    ACS Style

    Raziye Desdicioglu; Melahat Yildirim; Betul Ozbek; Gokhan Kılıc; Ozcan Erel, et al. Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis. J. Gynecol. Obstet. 2018, 6(1), 1-5. doi: 10.11648/j.jgo.20180601.11

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    AMA Style

    Raziye Desdicioglu, Melahat Yildirim, Betul Ozbek, Gokhan Kılıc, Ozcan Erel, et al. Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis. J Gynecol Obstet. 2018;6(1):1-5. doi: 10.11648/j.jgo.20180601.11

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  • @article{10.11648/j.jgo.20180601.11,
      author = {Raziye Desdicioglu and Melahat Yildirim and Betul Ozbek and Gokhan Kılıc and Ozcan Erel and Ayse Filiz Yavuz},
      title = {Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis},
      journal = {Journal of Gynecology and Obstetrics},
      volume = {6},
      number = {1},
      pages = {1-5},
      doi = {10.11648/j.jgo.20180601.11},
      url = {https://doi.org/10.11648/j.jgo.20180601.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.jgo.20180601.11},
      abstract = {This study investigated the thiol-disulphide balance in vaginitis, which is a local inflammatory condition, through the use of a new method. A cross-sectional study involving 82 women (45 women with vaginitis and 37 women in control group) was conducted at Ataturk Education and Research Hospital, Ankara, Turkey from February 2016 to April 2016. Their ages varied between 19-75 years (mean: 42.8±11.6), were incorporated into the study. Thiol – disulphide parameters were measured and the obtained results were compared. The results showed that the serum disulphide level and disulphide/native thiol ratio in the group with vaginitis (p = 0.03 and p = 0.04) and the native thiol/total thiol ratio in the control group was higher (p = 0.03). In this study, it was shown that serum dynamic thiol-disulphide balance in the women with vaginitis had varied. Although vaginitis is a localized infectious inflammatory condition, the increase in the systemic oxidative stress is important. This study is the first article in the literature that investigates the relationship between dynamic thiol-disulphide balance and vaginitis.},
     year = {2018}
    }
    

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  • TY  - JOUR
    T1  - Dynamic Thiol/Disulphide Homeostasis in Patients with Vaginitis
    AU  - Raziye Desdicioglu
    AU  - Melahat Yildirim
    AU  - Betul Ozbek
    AU  - Gokhan Kılıc
    AU  - Ozcan Erel
    AU  - Ayse Filiz Yavuz
    Y1  - 2018/01/16
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    DO  - 10.11648/j.jgo.20180601.11
    T2  - Journal of Gynecology and Obstetrics
    JF  - Journal of Gynecology and Obstetrics
    JO  - Journal of Gynecology and Obstetrics
    SP  - 1
    EP  - 5
    PB  - Science Publishing Group
    SN  - 2376-7820
    UR  - https://doi.org/10.11648/j.jgo.20180601.11
    AB  - This study investigated the thiol-disulphide balance in vaginitis, which is a local inflammatory condition, through the use of a new method. A cross-sectional study involving 82 women (45 women with vaginitis and 37 women in control group) was conducted at Ataturk Education and Research Hospital, Ankara, Turkey from February 2016 to April 2016. Their ages varied between 19-75 years (mean: 42.8±11.6), were incorporated into the study. Thiol – disulphide parameters were measured and the obtained results were compared. The results showed that the serum disulphide level and disulphide/native thiol ratio in the group with vaginitis (p = 0.03 and p = 0.04) and the native thiol/total thiol ratio in the control group was higher (p = 0.03). In this study, it was shown that serum dynamic thiol-disulphide balance in the women with vaginitis had varied. Although vaginitis is a localized infectious inflammatory condition, the increase in the systemic oxidative stress is important. This study is the first article in the literature that investigates the relationship between dynamic thiol-disulphide balance and vaginitis.
    VL  - 6
    IS  - 1
    ER  - 

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