Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region

Nevra Alkanli; Tammam Sipahi; Tulay Okman Kilic; Seralp Sener

doi:doi:10.11648/j.jgo.20140204.11

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Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region

Nevra Alkanli, Tammam Sipahi, Tulay Okman Kilic, Seralp Sener

Published in Journal of Gynecology and Obstetrics (Volume 2, Issue 4)

Received: 19 May 2014 Accepted: 10 June 2014 Published: 30 June 2014

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Abstract

The aim of this study was to investigate the distribution of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) and the distribution of Angiotensin II Type 1 Receptor A1166C (AGTR1 A1166C) gene polymorphisms in preeclamptic pregnant women comparing to control pregnant women in Turkish subjects of Trakya Region. We aimed to determine whether these polymorphisms are genetic risk factor for preeclampsia. The study included 75 preeclamptic pregnant women and 75 control pregnant women, which were categorized according to The World Health Organization Detecting Pre-eclampsia: A Practical Guide. The ACE I/D gene polymorphism was investigated using Polymerase Chain Reaction (PCR) method. The AGTR1 A1166C gene polymorphism was identified using PCR and followed by Restriction Fragment Length Polymorphism (RFLP) methods. The ACE I/D genotype distribution in preeclamptic pregnant women DD=36.0%, ID=44.0% and II=20.0% did not significantly differ from those in control pregnant women DD=38.7%, ID=50.7% and II=10.6% (P=0.279). The AGTR1 A1166C genotype distribution in preeclamptic pregnant women AA=57.3%, AC=33.4% and CC=9.3% also did not significantly differ from those in control pregnant women AA=70.7, AC=24.0% and CC=5.3% (P=0.223). This case-control study show that ACE I/D and AGTR1 A1166C gene polymorphisms are not genetic risk factors for preeclampsia in this population in Turkish pregnant women of Trakya Region.

Published in	Journal of Gynecology and Obstetrics (Volume 2, Issue 4)
DOI	10.11648/j.jgo.20140204.11
Page(s)	49-53
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Preeclampsia, ACE I/D Gene Polymorphism, AGTR1 A1166C Gene Polymorphism, PCR, RFLP

References

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APA Style

Nevra Alkanli, Tammam Sipahi, Tulay Okman Kilic, Seralp Sener. (2014). Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region. Journal of Gynecology and Obstetrics, 2(4), 49-53. https://doi.org/10.11648/j.jgo.20140204.11

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ACS Style

Nevra Alkanli; Tammam Sipahi; Tulay Okman Kilic; Seralp Sener. Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region. J. Gynecol. Obstet. 2014, 2(4), 49-53. doi: 10.11648/j.jgo.20140204.11

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AMA Style

Nevra Alkanli, Tammam Sipahi, Tulay Okman Kilic, Seralp Sener. Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region. J Gynecol Obstet. 2014;2(4):49-53. doi: 10.11648/j.jgo.20140204.11

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@article{10.11648/j.jgo.20140204.11,
  author = {Nevra Alkanli and Tammam Sipahi and Tulay Okman Kilic and Seralp Sener},
  title = {Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {2},
  number = {4},
  pages = {49-53},
  doi = {10.11648/j.jgo.20140204.11},
  url = {https://doi.org/10.11648/j.jgo.20140204.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20140204.11},
  abstract = {The aim of this study was to investigate the distribution of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) and the distribution of Angiotensin II Type 1 Receptor A1166C (AGTR1 A1166C) gene polymorphisms in preeclamptic pregnant women comparing to control pregnant women in Turkish subjects of Trakya Region. We aimed to determine whether these polymorphisms are genetic risk factor for preeclampsia. The study included 75 preeclamptic pregnant women and 75 control pregnant women, which were categorized according to The World Health Organization Detecting Pre-eclampsia: A Practical Guide. The ACE I/D gene polymorphism was investigated using Polymerase Chain Reaction (PCR) method. The AGTR1 A1166C gene polymorphism was identified using PCR and followed by Restriction Fragment Length Polymorphism (RFLP) methods. The ACE I/D genotype distribution in preeclamptic pregnant women DD=36.0%, ID=44.0% and II=20.0% did not significantly differ from those in control pregnant women DD=38.7%, ID=50.7% and II=10.6% (P=0.279). The AGTR1 A1166C genotype distribution in preeclamptic pregnant women AA=57.3%, AC=33.4% and CC=9.3% also did not significantly differ from those in control pregnant women AA=70.7, AC=24.0% and CC=5.3% (P=0.223). This case-control study show that ACE I/D and AGTR1 A1166C gene polymorphisms are not genetic risk factors for preeclampsia in this population in Turkish pregnant women of Trakya Region.},
 year = {2014}
}

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TY  - JOUR
T1  - Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region
AU  - Nevra Alkanli
AU  - Tammam Sipahi
AU  - Tulay Okman Kilic
AU  - Seralp Sener
Y1  - 2014/06/30
PY  - 2014
N1  - https://doi.org/10.11648/j.jgo.20140204.11
DO  - 10.11648/j.jgo.20140204.11
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 49
EP  - 53
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20140204.11
AB  - The aim of this study was to investigate the distribution of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) and the distribution of Angiotensin II Type 1 Receptor A1166C (AGTR1 A1166C) gene polymorphisms in preeclamptic pregnant women comparing to control pregnant women in Turkish subjects of Trakya Region. We aimed to determine whether these polymorphisms are genetic risk factor for preeclampsia. The study included 75 preeclamptic pregnant women and 75 control pregnant women, which were categorized according to The World Health Organization Detecting Pre-eclampsia: A Practical Guide. The ACE I/D gene polymorphism was investigated using Polymerase Chain Reaction (PCR) method. The AGTR1 A1166C gene polymorphism was identified using PCR and followed by Restriction Fragment Length Polymorphism (RFLP) methods. The ACE I/D genotype distribution in preeclamptic pregnant women DD=36.0%, ID=44.0% and II=20.0% did not significantly differ from those in control pregnant women DD=38.7%, ID=50.7% and II=10.6% (P=0.279). The AGTR1 A1166C genotype distribution in preeclamptic pregnant women AA=57.3%, AC=33.4% and CC=9.3% also did not significantly differ from those in control pregnant women AA=70.7, AC=24.0% and CC=5.3% (P=0.223). This case-control study show that ACE I/D and AGTR1 A1166C gene polymorphisms are not genetic risk factors for preeclampsia in this population in Turkish pregnant women of Trakya Region.
VL  - 2
IS  - 4
ER  -

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Author Information

Nevra Alkanli

Department of Biophysics, Faculty of Medicine, Trakya University, Edirne, Turkey
Tammam Sipahi

Department of Biophysics, Faculty of Medicine, Trakya University, Edirne, Turkey
Tulay Okman Kilic

Department of Obstetrics and Gynecology, Faculty of Medicine, Trakya University, Edirne, Turkey
Seralp Sener

Department of Biophysics, Faculty of Medicine, Trakya University, Edirne, Turkey

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APA Style

Nevra Alkanli, Tammam Sipahi, Tulay Okman Kilic, Seralp Sener. (2014). Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region. Journal of Gynecology and Obstetrics, 2(4), 49-53. https://doi.org/10.11648/j.jgo.20140204.11

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ACS Style

Nevra Alkanli; Tammam Sipahi; Tulay Okman Kilic; Seralp Sener. Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region. J. Gynecol. Obstet. 2014, 2(4), 49-53. doi: 10.11648/j.jgo.20140204.11

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AMA Style

Nevra Alkanli, Tammam Sipahi, Tulay Okman Kilic, Seralp Sener. Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region. J Gynecol Obstet. 2014;2(4):49-53. doi: 10.11648/j.jgo.20140204.11

Copy | Download

@article{10.11648/j.jgo.20140204.11,
  author = {Nevra Alkanli and Tammam Sipahi and Tulay Okman Kilic and Seralp Sener},
  title = {Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region},
  journal = {Journal of Gynecology and Obstetrics},
  volume = {2},
  number = {4},
  pages = {49-53},
  doi = {10.11648/j.jgo.20140204.11},
  url = {https://doi.org/10.11648/j.jgo.20140204.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.jgo.20140204.11},
  abstract = {The aim of this study was to investigate the distribution of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) and the distribution of Angiotensin II Type 1 Receptor A1166C (AGTR1 A1166C) gene polymorphisms in preeclamptic pregnant women comparing to control pregnant women in Turkish subjects of Trakya Region. We aimed to determine whether these polymorphisms are genetic risk factor for preeclampsia. The study included 75 preeclamptic pregnant women and 75 control pregnant women, which were categorized according to The World Health Organization Detecting Pre-eclampsia: A Practical Guide. The ACE I/D gene polymorphism was investigated using Polymerase Chain Reaction (PCR) method. The AGTR1 A1166C gene polymorphism was identified using PCR and followed by Restriction Fragment Length Polymorphism (RFLP) methods. The ACE I/D genotype distribution in preeclamptic pregnant women DD=36.0%, ID=44.0% and II=20.0% did not significantly differ from those in control pregnant women DD=38.7%, ID=50.7% and II=10.6% (P=0.279). The AGTR1 A1166C genotype distribution in preeclamptic pregnant women AA=57.3%, AC=33.4% and CC=9.3% also did not significantly differ from those in control pregnant women AA=70.7, AC=24.0% and CC=5.3% (P=0.223). This case-control study show that ACE I/D and AGTR1 A1166C gene polymorphisms are not genetic risk factors for preeclampsia in this population in Turkish pregnant women of Trakya Region.},
 year = {2014}
}

Copy | Download

TY  - JOUR
T1  - Lack of Association between ACE I/D and AGTR1 A1166C Gene Polymorphisms and Preeclampsia in Turkish Pregnant Women of Trakya Region
AU  - Nevra Alkanli
AU  - Tammam Sipahi
AU  - Tulay Okman Kilic
AU  - Seralp Sener
Y1  - 2014/06/30
PY  - 2014
N1  - https://doi.org/10.11648/j.jgo.20140204.11
DO  - 10.11648/j.jgo.20140204.11
T2  - Journal of Gynecology and Obstetrics
JF  - Journal of Gynecology and Obstetrics
JO  - Journal of Gynecology and Obstetrics
SP  - 49
EP  - 53
PB  - Science Publishing Group
SN  - 2376-7820
UR  - https://doi.org/10.11648/j.jgo.20140204.11
AB  - The aim of this study was to investigate the distribution of Angiotensin Converting Enzyme Insertion/Deletion (ACE I/D) and the distribution of Angiotensin II Type 1 Receptor A1166C (AGTR1 A1166C) gene polymorphisms in preeclamptic pregnant women comparing to control pregnant women in Turkish subjects of Trakya Region. We aimed to determine whether these polymorphisms are genetic risk factor for preeclampsia. The study included 75 preeclamptic pregnant women and 75 control pregnant women, which were categorized according to The World Health Organization Detecting Pre-eclampsia: A Practical Guide. The ACE I/D gene polymorphism was investigated using Polymerase Chain Reaction (PCR) method. The AGTR1 A1166C gene polymorphism was identified using PCR and followed by Restriction Fragment Length Polymorphism (RFLP) methods. The ACE I/D genotype distribution in preeclamptic pregnant women DD=36.0%, ID=44.0% and II=20.0% did not significantly differ from those in control pregnant women DD=38.7%, ID=50.7% and II=10.6% (P=0.279). The AGTR1 A1166C genotype distribution in preeclamptic pregnant women AA=57.3%, AC=33.4% and CC=9.3% also did not significantly differ from those in control pregnant women AA=70.7, AC=24.0% and CC=5.3% (P=0.223). This case-control study show that ACE I/D and AGTR1 A1166C gene polymorphisms are not genetic risk factors for preeclampsia in this population in Turkish pregnant women of Trakya Region.
VL  - 2
IS  - 4
ER  -

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