American Journal of Clinical and Experimental Medicine

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Oxygen Ozone Therapy in the Treatment of Chronic Obstructive Pulmonary Disease: An Integrative Approach

Received: 19 January 2014    Accepted:     Published: 10 March 2014
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Abstract

A pilot study has been performed on fifty COPD patients: besides using effective drugs, half of the patients have been treated also with major ozonated autohaemotherapy . This treatment has been evaluated during the last two decades and is absolutely atoxic: the treated patients have shown a significant improvement of the six minute walking test and Saint George Respiratory Questionnaire total score. Surprisingly their quality of life was also much improved. Orthodox medications appears to be greatly potentiated when integrated by the autologous infusion of ozonated blood. This combination deserves to be evaluated in an ample clinical trial.

DOI 10.11648/j.ajcem.20140202.11
Published in American Journal of Clinical and Experimental Medicine (Volume 2, Issue 2, March 2014)
Page(s) 9-13
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Ozonetherapy, Chronic Obstructive Pulmonary Disease, Oxygen Radicals

References
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[8] Thomsen M, Ingebrigtsen TS, Marott JL, Dahl M, Lange P, Vestbo J, Nordestgaard BG. Inflammatory biomarkers and exacerbations in chronic obstructive pulmonary disease. JAMA 2013 12 ; 309 (22) : 2353-61
[9] Bocci V, Borrelli E, Travagli V, Zanardi I. The ozone paradox: ozone is a strong oxidant as well as a medical drug. Medic Res Rev 29: 646-82, 2009
[10] Bocci V. A new method for the activation of the cellular antioxidant system. Oxidants and Antioxidants in Medical Science 2013 2 (3) 149-154.
[11] Bocci V. Ozone. A new medical drug. 2nd Edition. Springer Editor. 2011, pp. 1-315
[12] Borrelli E, Bocci V. Basic biological and therapeutic effects of ozonetherapy in medicine In: Encyclopedia of Life Support Systems (EOLSS), Developed under the Auspices of the UNESCO, Eolss Publishers, Oxford ,UK, [http://www.eolss.net].
[13] Bocci V. Is it true that ozone is always toxic? The end of the dogma. Toxicol. Appl. Pharmacol. 2006; 216: 493-504.
[14] Bocci V, Zanardi I, Michaeli D, Travagli V. Mechanisms of action and chemical-biological interactions between ozone and body compartments: a critical appraisal of the different administration routes. Current Drug Therapy 2009, 4: 159-175.
[15] Pecorelli A, Bocci V, Acquaviva A, Belmonte G, Gardi C, Virgili F, Ciccoli L, Valacchi G. Nrf2 activation is involved in ozonated human serum upregulation of HO-1 in endothelial cells. Toxicology and Applied Pharmacology 2013; 267:30-40
[16] Qaseem A, Wilt TJ, Weinberger SE, Hanania NA, Criner G, van der Molen T, Marciniuk DD, Denberg T, Schünemann H, Wedzicha W, MacDonald R, Shekelle P; American College of Physicians; American College of Chest Physicians; American Thoracic Society; European Respiratory Society . Diagnosis and management of stable chronic obstructive pulmonary disease: a clinical practice guideline update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society,and European Respiratory Society. Ann Intern Med 2011; 155: 179–91
[17] Wegner R, Jörres RA, Kirsten DK, Magnussen H. Factor analysis of exercise capacity, dyspnoea ratings and lung function in patients with severe COPD. Eur Respir J 1994;7:725-9
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Author Information
  • Department of Medical Biotechnologies, University of Siena, Italy

  • Department of Biotechnologies, University of Siena, Italy

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  • APA Style

    Emma Borrelli, Velio Bocci. (2014). Oxygen Ozone Therapy in the Treatment of Chronic Obstructive Pulmonary Disease: An Integrative Approach. American Journal of Clinical and Experimental Medicine, 2(2), 9-13. https://doi.org/10.11648/j.ajcem.20140202.11

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    ACS Style

    Emma Borrelli; Velio Bocci. Oxygen Ozone Therapy in the Treatment of Chronic Obstructive Pulmonary Disease: An Integrative Approach. Am. J. Clin. Exp. Med. 2014, 2(2), 9-13. doi: 10.11648/j.ajcem.20140202.11

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    AMA Style

    Emma Borrelli, Velio Bocci. Oxygen Ozone Therapy in the Treatment of Chronic Obstructive Pulmonary Disease: An Integrative Approach. Am J Clin Exp Med. 2014;2(2):9-13. doi: 10.11648/j.ajcem.20140202.11

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  • @article{10.11648/j.ajcem.20140202.11,
      author = {Emma Borrelli and Velio Bocci},
      title = {Oxygen Ozone Therapy in the Treatment of Chronic Obstructive Pulmonary Disease: An Integrative Approach},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {2},
      number = {2},
      pages = {9-13},
      doi = {10.11648/j.ajcem.20140202.11},
      url = {https://doi.org/10.11648/j.ajcem.20140202.11},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20140202.11},
      abstract = {A pilot study has been performed on fifty COPD patients: besides using effective drugs, half of the patients have been treated also with major ozonated autohaemotherapy . This treatment has been evaluated during the last two decades and is absolutely atoxic: the treated patients have shown a significant improvement of the six minute walking test and Saint George Respiratory Questionnaire total score. Surprisingly their quality of life was also much improved. Orthodox medications appears to be greatly potentiated when integrated by the autologous infusion of ozonated blood. This combination deserves to be evaluated in an ample clinical trial.},
     year = {2014}
    }
    

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    AB  - A pilot study has been performed on fifty COPD patients: besides using effective drugs, half of the patients have been treated also with major ozonated autohaemotherapy . This treatment has been evaluated during the last two decades and is absolutely atoxic: the treated patients have shown a significant improvement of the six minute walking test and Saint George Respiratory Questionnaire total score. Surprisingly their quality of life was also much improved. Orthodox medications appears to be greatly potentiated when integrated by the autologous infusion of ozonated blood. This combination deserves to be evaluated in an ample clinical trial.
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