Research Progress on Regulatory T Cell Differentiation and Regulation

Jing Feng; Zhaoxin Mu; Zhenjiang Hou

doi:doi:10.11648/j.ajcem.20200803.11

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Research Progress on Regulatory T Cell Differentiation and Regulation

Jing Feng, Zhaoxin Mu, Zhenjiang Hou

Received: 10 April 2020 Accepted: Published: 8 June 2020

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Abstract

Regulatory T cells (Treg) are a subset of T cells with immunosuppressive functions. According to the source and mechanism of Treg cells, they are divided into natural regulatory T cells (nTreg) and induced regulatory T cells (iTreg). According to the different properties of secreted cytokines, they are divided into two types: pro-inflammatory and anti-inflammatory cells. Pro-inflammatory Treg cells that secrete IFN-ã are closely related to the development of autoimmune diseases, while anti-inflammatory Treg cells that secrete IL-10 can reduce the development of slow inflammation. In addition to secreting a variety of inhibitory cytokines such as IL-10 and TGF-â, Treg cells also exert immunosuppressive effects through direct contact among cells to jointly maintain the body's immune tolerance and suppress immune responses. By suppressing the autoimmune response of effector T cells and promoting immune tolerance, it has a very important role in maintaining the homeostasis of the body. The differentiation and regulation of Treg cells and their relationship with autoimmune diseases have been hotspots in the field of immunology in recent years. This article reviews the source of Treg, differentiation regulation, classification, markers, functions and mechanisms of action so as to deepen the understanding of Treg cell differentiation and immune regulation mechanisms, and further broaden the research horizon and thinking.

DOI	10.11648/j.ajcem.20200803.11
Published in	American Journal of Clinical and Experimental Medicine (Volume 8, Issue 3, May 2020)
Page(s)	25-34
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Regulatory T Cells, Cluster of Differentiation 4⁺T Cells, Interleukin-10, Transforming Growth Factor-β, Forkhead Box p3, Signal Transduction and Activator of Transcription

References

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Jing Feng, Zhaoxin Mu, Zhenjiang Hou. (2020). Research Progress on Regulatory T Cell Differentiation and Regulation. American Journal of Clinical and Experimental Medicine, 8(3), 25-34. https://doi.org/10.11648/j.ajcem.20200803.11

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Jing Feng; Zhaoxin Mu; Zhenjiang Hou. Research Progress on Regulatory T Cell Differentiation and Regulation. Am. J. Clin. Exp. Med. 2020, 8(3), 25-34. doi: 10.11648/j.ajcem.20200803.11

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AMA Style

Jing Feng, Zhaoxin Mu, Zhenjiang Hou. Research Progress on Regulatory T Cell Differentiation and Regulation. Am J Clin Exp Med. 2020;8(3):25-34. doi: 10.11648/j.ajcem.20200803.11

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@article{10.11648/j.ajcem.20200803.11,
  author = {Jing Feng and Zhaoxin Mu and Zhenjiang Hou},
  title = {Research Progress on Regulatory T Cell Differentiation and Regulation},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {8},
  number = {3},
  pages = {25-34},
  doi = {10.11648/j.ajcem.20200803.11},
  url = {https://doi.org/10.11648/j.ajcem.20200803.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20200803.11},
  abstract = {Regulatory T cells (Treg) are a subset of T cells with immunosuppressive functions. According to the source and mechanism of Treg cells, they are divided into natural regulatory T cells (nTreg) and induced regulatory T cells (iTreg). According to the different properties of secreted cytokines, they are divided into two types: pro-inflammatory and anti-inflammatory cells. Pro-inflammatory Treg cells that secrete IFN-ã are closely related to the development of autoimmune diseases, while anti-inflammatory Treg cells that secrete IL-10 can reduce the development of slow inflammation. In addition to secreting a variety of inhibitory cytokines such as IL-10 and TGF-â, Treg cells also exert immunosuppressive effects through direct contact among cells to jointly maintain the body's immune tolerance and suppress immune responses. By suppressing the autoimmune response of effector T cells and promoting immune tolerance, it has a very important role in maintaining the homeostasis of the body. The differentiation and regulation of Treg cells and their relationship with autoimmune diseases have been hotspots in the field of immunology in recent years. This article reviews the source of Treg, differentiation regulation, classification, markers, functions and mechanisms of action so as to deepen the understanding of Treg cell differentiation and immune regulation mechanisms, and further broaden the research horizon and thinking.},
 year = {2020}
}

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TY  - JOUR
T1  - Research Progress on Regulatory T Cell Differentiation and Regulation
AU  - Jing Feng
AU  - Zhaoxin Mu
AU  - Zhenjiang Hou
Y1  - 2020/06/08
PY  - 2020
N1  - https://doi.org/10.11648/j.ajcem.20200803.11
DO  - 10.11648/j.ajcem.20200803.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 25
EP  - 34
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20200803.11
AB  - Regulatory T cells (Treg) are a subset of T cells with immunosuppressive functions. According to the source and mechanism of Treg cells, they are divided into natural regulatory T cells (nTreg) and induced regulatory T cells (iTreg). According to the different properties of secreted cytokines, they are divided into two types: pro-inflammatory and anti-inflammatory cells. Pro-inflammatory Treg cells that secrete IFN-ã are closely related to the development of autoimmune diseases, while anti-inflammatory Treg cells that secrete IL-10 can reduce the development of slow inflammation. In addition to secreting a variety of inhibitory cytokines such as IL-10 and TGF-â, Treg cells also exert immunosuppressive effects through direct contact among cells to jointly maintain the body's immune tolerance and suppress immune responses. By suppressing the autoimmune response of effector T cells and promoting immune tolerance, it has a very important role in maintaining the homeostasis of the body. The differentiation and regulation of Treg cells and their relationship with autoimmune diseases have been hotspots in the field of immunology in recent years. This article reviews the source of Treg, differentiation regulation, classification, markers, functions and mechanisms of action so as to deepen the understanding of Treg cell differentiation and immune regulation mechanisms, and further broaden the research horizon and thinking.
VL  - 8
IS  - 3
ER  -

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Author Information

Jing Feng

Cangzhou Central Hospital, Cangzhou, China
Zhaoxin Mu

Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China
Zhenjiang Hou

Institute of Thyroid Diseases Affiliated to Cangzhou Medical College, Cangzhou Thyroid Disease Engineering Technology Research Center, Cangzhou, China

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APA Style

Jing Feng, Zhaoxin Mu, Zhenjiang Hou. (2020). Research Progress on Regulatory T Cell Differentiation and Regulation. American Journal of Clinical and Experimental Medicine, 8(3), 25-34. https://doi.org/10.11648/j.ajcem.20200803.11

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ACS Style

Jing Feng; Zhaoxin Mu; Zhenjiang Hou. Research Progress on Regulatory T Cell Differentiation and Regulation. Am. J. Clin. Exp. Med. 2020, 8(3), 25-34. doi: 10.11648/j.ajcem.20200803.11

Copy | Download

AMA Style

Jing Feng, Zhaoxin Mu, Zhenjiang Hou. Research Progress on Regulatory T Cell Differentiation and Regulation. Am J Clin Exp Med. 2020;8(3):25-34. doi: 10.11648/j.ajcem.20200803.11

Copy | Download

@article{10.11648/j.ajcem.20200803.11,
  author = {Jing Feng and Zhaoxin Mu and Zhenjiang Hou},
  title = {Research Progress on Regulatory T Cell Differentiation and Regulation},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {8},
  number = {3},
  pages = {25-34},
  doi = {10.11648/j.ajcem.20200803.11},
  url = {https://doi.org/10.11648/j.ajcem.20200803.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20200803.11},
  abstract = {Regulatory T cells (Treg) are a subset of T cells with immunosuppressive functions. According to the source and mechanism of Treg cells, they are divided into natural regulatory T cells (nTreg) and induced regulatory T cells (iTreg). According to the different properties of secreted cytokines, they are divided into two types: pro-inflammatory and anti-inflammatory cells. Pro-inflammatory Treg cells that secrete IFN-ã are closely related to the development of autoimmune diseases, while anti-inflammatory Treg cells that secrete IL-10 can reduce the development of slow inflammation. In addition to secreting a variety of inhibitory cytokines such as IL-10 and TGF-â, Treg cells also exert immunosuppressive effects through direct contact among cells to jointly maintain the body's immune tolerance and suppress immune responses. By suppressing the autoimmune response of effector T cells and promoting immune tolerance, it has a very important role in maintaining the homeostasis of the body. The differentiation and regulation of Treg cells and their relationship with autoimmune diseases have been hotspots in the field of immunology in recent years. This article reviews the source of Treg, differentiation regulation, classification, markers, functions and mechanisms of action so as to deepen the understanding of Treg cell differentiation and immune regulation mechanisms, and further broaden the research horizon and thinking.},
 year = {2020}
}

Copy | Download

TY  - JOUR
T1  - Research Progress on Regulatory T Cell Differentiation and Regulation
AU  - Jing Feng
AU  - Zhaoxin Mu
AU  - Zhenjiang Hou
Y1  - 2020/06/08
PY  - 2020
N1  - https://doi.org/10.11648/j.ajcem.20200803.11
DO  - 10.11648/j.ajcem.20200803.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 25
EP  - 34
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20200803.11
AB  - Regulatory T cells (Treg) are a subset of T cells with immunosuppressive functions. According to the source and mechanism of Treg cells, they are divided into natural regulatory T cells (nTreg) and induced regulatory T cells (iTreg). According to the different properties of secreted cytokines, they are divided into two types: pro-inflammatory and anti-inflammatory cells. Pro-inflammatory Treg cells that secrete IFN-ã are closely related to the development of autoimmune diseases, while anti-inflammatory Treg cells that secrete IL-10 can reduce the development of slow inflammation. In addition to secreting a variety of inhibitory cytokines such as IL-10 and TGF-â, Treg cells also exert immunosuppressive effects through direct contact among cells to jointly maintain the body's immune tolerance and suppress immune responses. By suppressing the autoimmune response of effector T cells and promoting immune tolerance, it has a very important role in maintaining the homeostasis of the body. The differentiation and regulation of Treg cells and their relationship with autoimmune diseases have been hotspots in the field of immunology in recent years. This article reviews the source of Treg, differentiation regulation, classification, markers, functions and mechanisms of action so as to deepen the understanding of Treg cell differentiation and immune regulation mechanisms, and further broaden the research horizon and thinking.
VL  - 8
IS  - 3
ER  -

Copy | Download