Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma

Andi Miranti; Anis Irawan Anwar; Khairuddin Djawad; Ilhamjaya Patellongi; Siswanto Wahab; Nusratuddin Abdullah

doi:doi:10.11648/j.ajcem.20160402.13

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Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma

Andi Miranti, Anis Irawan Anwar, Khairuddin Djawad, Ilhamjaya Patellongi, Siswanto Wahab, Nusratuddin Abdullah

Published in American Journal of Clinical and Experimental Medicine (Volume 4, Issue 2)

Received: 15 February 2016 Accepted: 29 February 2016 Published: 21 March 2016

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Abstract

Hormonal changes in pregnancy are the important etiology of melasma. The presence of melasma in more than 75% of pregnancies. At the end of pregnancy, estrogen levels increase. Estrogen, especially estradiol triggers increased synthesis of melanin. This paper is aimed to determine the relationship between estradiol hormone with melasma and the type ofmelasma in pregnant women. This study used a cross-sectional study design to determine the relationship of estradiol hormone with melasma. It was conducted from September-November 2015. Skin examination was performed on 64 pregnant women (15-49 years old) who suffered from melasma in the third trimester and who did not, and the blood was drawn to measure the level of serum estradiol hormone. The study results that the levels of estradiol was slightly higher in women with melasma than those without melasma (13811.7 vs 12820.5), but not statistically significant (p>0.05). There was slightly higher levels of estradiol in women with the mixed type of melasma than the other types (14444.10 vs 14047.25 and 12243.50), but it was not statistically significant (p>0.05). Estradiol levels correlated significantly (p<0.05) with maternal age (r = 0.238) and gestational age (r = 0.435); but did not correlate significantly (p>0.05) with MASI (Melasma Area Severity Index) score and the type of melasma. The study concluded that estradiol levels in women with melasma are higher than not melasma and in mothers with type mix melasma were higher than other types, but not statistically significant. Estradiol level correlated with maternal age and gestational age.

Published in	American Journal of Clinical and Experimental Medicine (Volume 4, Issue 2)
DOI	10.11648/j.ajcem.20160402.13
Page(s)	26-29
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Estradiol, Melasma, Pregnant

References

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[2]	Sardesai, V. R., Kolte, J. N., Srinivas, B. N. 2013. A clinical study of melasma and a comparison of the therapeutic effect of certain currently available topical modalities for its treatment.Indian J Dermatol. 58: 1-5.
[3]	Akram, S., Sattar, F., Tahir, R., Mujtaba, G. 2013. Efficacy of topical 4% liquiritin compared with topical 4% liquiritincampuran in 5% ascorbic acid in the treatment of melasma. Journal of Pakistan Association of Dermatologists. 2: 149-152.
[4]	Sarkar, R., Arora, P., Garg, V. K., Sonthalia, S., Gokhale, N. 2014. Melasma update. Indian Dermatology Online Journal. 5: 426-435.
[5]	Handel, A. C., Miot, L. D. B. Miot, H. A., 2014. Melasma: a clinical and epidemiological review. An Bras Dermatol. 5: 771-782.
[6]	Jadotte, Y. T., Schwartz, R. A. 2010. Melasma: Insight and Perspectives. Acta Dermatovenerol Croat. 2: 124-129.
[7]	Moin, A., Jabery Z., Fallah N. 2006. Prevalence and awareness of melasma during pregnancy. International Journal of Dermatology. 45: 285-288.
[8]	Rakhmawati, D. 2013. Pengaruh Kadar Estradiol Basal terhadap Melasma. Tesis tidak diterbitkan. Yogyakarta: Fakultas Kedokteran - Universitas Gadjah Mada.
[9]	Wiedemann, C., Nagele, U., Schramm, G., Berking, C. 2009. Inhibitory effects of progesterons on the estrogen stimulation of melanocytes in vitro. Contraception. 80: 292-298.
[10]	Cestari, T. F., Andrade, C. B. 2005. Hyperpigmentation and Melasma: A physiopathologic review for the clinical dermatologist. Cosmetic Dermatology. 10: 703-706.
[11]	Im, S., Lee, E-S., Kim, W., On, W., Kim, J., Lee, M., Kang, W.H. 2002. Donor Specific Response of Estrogen and Progesterone on Cultured Human Melanocytes. J Korean Med Sci. 17: 58-64.
[12]	Costin, G. E., Birlea, S. A. 2006. What is the mechanism for melasma that so commonly accompanies human pregnancy? IUBMB life. 52(1): 55-57.
[13]	Anwar, R. 2005. Endokrinologi Kehamilandan Persalinan. Bandung: Fakultas Kedokteran UNPAD.
[14]	Thornton, M. J. 2002. Experimental Dermatology. 11: 487-502.
[15]	Damevska, K. 2014. New Aspects of Melasma. Serbian Journal of Dermatology and Venereology. 6(1): 5-18.
[16]	Stulberg, D. L., Clark, N., Tovey, D. 2003. Common Hyperpigmentation Disorders in Adults: Part II. Melanoma, Seborrheic Keratoses, Acanthosis Nigricans, Melasma, Diabetic Dermopathy, Tinea Versicolor, and Postinflammatory Hyperpigmentation. Am Fam Physician. 68: 1963-8.
[17]	Doria, A., Iaccarino, L., Sarzi-Puttini, P., Ghirardello, A., Zampieri, S., Arienti, S., Cutolo, M., Todesco, S. 2006. Estrogens in Pregnancy and Systemic Lupus Erythematosus. Annals New York Academy of Sciences. 1069: 247-256.

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Andi Miranti, Anis Irawan Anwar, Khairuddin Djawad, Ilhamjaya Patellongi, Siswanto Wahab, et al. (2016). Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma. American Journal of Clinical and Experimental Medicine, 4(2), 26-29. https://doi.org/10.11648/j.ajcem.20160402.13

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ACS Style

Andi Miranti; Anis Irawan Anwar; Khairuddin Djawad; Ilhamjaya Patellongi; Siswanto Wahab, et al. Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma. Am. J. Clin. Exp. Med. 2016, 4(2), 26-29. doi: 10.11648/j.ajcem.20160402.13

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AMA Style

Andi Miranti, Anis Irawan Anwar, Khairuddin Djawad, Ilhamjaya Patellongi, Siswanto Wahab, et al. Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma. Am J Clin Exp Med. 2016;4(2):26-29. doi: 10.11648/j.ajcem.20160402.13

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@article{10.11648/j.ajcem.20160402.13,
  author = {Andi Miranti and Anis Irawan Anwar and Khairuddin Djawad and Ilhamjaya Patellongi and Siswanto Wahab and Nusratuddin Abdullah},
  title = {Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {2},
  pages = {26-29},
  doi = {10.11648/j.ajcem.20160402.13},
  url = {https://doi.org/10.11648/j.ajcem.20160402.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160402.13},
  abstract = {Hormonal changes in pregnancy are the important etiology of melasma. The presence of melasma in more than 75% of pregnancies. At the end of pregnancy, estrogen levels increase. Estrogen, especially estradiol triggers increased synthesis of melanin. This paper is aimed to determine the relationship between estradiol hormone with melasma and the type ofmelasma in pregnant women. This study used a cross-sectional study design to determine the relationship of estradiol hormone with melasma. It was conducted from September-November 2015. Skin examination was performed on 64 pregnant women (15-49 years old) who suffered from melasma in the third trimester and who did not, and the blood was drawn to measure the level of serum estradiol hormone. The study results that the levels of estradiol was slightly higher in women with melasma than those without melasma (13811.7 vs 12820.5), but not statistically significant (p>0.05). There was slightly higher levels of estradiol in women with the mixed type of melasma than the other types (14444.10 vs 14047.25 and 12243.50), but it was not statistically significant (p>0.05). Estradiol levels correlated significantly (p0.05) with MASI (Melasma Area Severity Index) score and the type of melasma. The study concluded that estradiol levels in women with melasma are higher than not melasma and in mothers with type mix melasma were higher than other types, but not statistically significant. Estradiol level correlated with maternal age and gestational age.},
 year = {2016}
}

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TY - JOUR
T1 - Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma
AU - Andi Miranti
AU - Anis Irawan Anwar
AU - Khairuddin Djawad
AU - Ilhamjaya Patellongi
AU - Siswanto Wahab
AU - Nusratuddin Abdullah
Y1 - 2016/03/21
PY - 2016
N1 - https://doi.org/10.11648/j.ajcem.20160402.13
DO - 10.11648/j.ajcem.20160402.13
T2 - American Journal of Clinical and Experimental Medicine
JF - American Journal of Clinical and Experimental Medicine
JO - American Journal of Clinical and Experimental Medicine
SP - 26
EP - 29
PB - Science Publishing Group
SN - 2330-8133
UR - https://doi.org/10.11648/j.ajcem.20160402.13
AB - Hormonal changes in pregnancy are the important etiology of melasma. The presence of melasma in more than 75% of pregnancies. At the end of pregnancy, estrogen levels increase. Estrogen, especially estradiol triggers increased synthesis of melanin. This paper is aimed to determine the relationship between estradiol hormone with melasma and the type ofmelasma in pregnant women. This study used a cross-sectional study design to determine the relationship of estradiol hormone with melasma. It was conducted from September-November 2015. Skin examination was performed on 64 pregnant women (15-49 years old) who suffered from melasma in the third trimester and who did not, and the blood was drawn to measure the level of serum estradiol hormone. The study results that the levels of estradiol was slightly higher in women with melasma than those without melasma (13811.7 vs 12820.5), but not statistically significant (p>0.05). There was slightly higher levels of estradiol in women with the mixed type of melasma than the other types (14444.10 vs 14047.25 and 12243.50), but it was not statistically significant (p>0.05). Estradiol levels correlated significantly (p0.05) with MASI (Melasma Area Severity Index) score and the type of melasma. The study concluded that estradiol levels in women with melasma are higher than not melasma and in mothers with type mix melasma were higher than other types, but not statistically significant. Estradiol level correlated with maternal age and gestational age.
VL - 4
IS - 2
ER -

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Author Information

Andi Miranti

Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Anis Irawan Anwar

Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Khairuddin Djawad

Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Ilhamjaya Patellongi

Faculty of Public Health, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Siswanto Wahab

Department of Dermatology, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia
Nusratuddin Abdullah

Department of Obstetric and Ginecology, Medical Faculty, Hasanuddin University, Makassar, South Sulawesi, Indonesia

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APA Style

Andi Miranti, Anis Irawan Anwar, Khairuddin Djawad, Ilhamjaya Patellongi, Siswanto Wahab, et al. (2016). Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma. American Journal of Clinical and Experimental Medicine, 4(2), 26-29. https://doi.org/10.11648/j.ajcem.20160402.13

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ACS Style

Andi Miranti; Anis Irawan Anwar; Khairuddin Djawad; Ilhamjaya Patellongi; Siswanto Wahab, et al. Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma. Am. J. Clin. Exp. Med. 2016, 4(2), 26-29. doi: 10.11648/j.ajcem.20160402.13

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AMA Style

Andi Miranti, Anis Irawan Anwar, Khairuddin Djawad, Ilhamjaya Patellongi, Siswanto Wahab, et al. Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma. Am J Clin Exp Med. 2016;4(2):26-29. doi: 10.11648/j.ajcem.20160402.13

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@article{10.11648/j.ajcem.20160402.13,
  author = {Andi Miranti and Anis Irawan Anwar and Khairuddin Djawad and Ilhamjaya Patellongi and Siswanto Wahab and Nusratuddin Abdullah},
  title = {Analysis Level of Serum Estradiol Hormone of Pregnant Women with Melasma},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {4},
  number = {2},
  pages = {26-29},
  doi = {10.11648/j.ajcem.20160402.13},
  url = {https://doi.org/10.11648/j.ajcem.20160402.13},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20160402.13},
  abstract = {Hormonal changes in pregnancy are the important etiology of melasma. The presence of melasma in more than 75% of pregnancies. At the end of pregnancy, estrogen levels increase. Estrogen, especially estradiol triggers increased synthesis of melanin. This paper is aimed to determine the relationship between estradiol hormone with melasma and the type ofmelasma in pregnant women. This study used a cross-sectional study design to determine the relationship of estradiol hormone with melasma. It was conducted from September-November 2015. Skin examination was performed on 64 pregnant women (15-49 years old) who suffered from melasma in the third trimester and who did not, and the blood was drawn to measure the level of serum estradiol hormone. The study results that the levels of estradiol was slightly higher in women with melasma than those without melasma (13811.7 vs 12820.5), but not statistically significant (p>0.05). There was slightly higher levels of estradiol in women with the mixed type of melasma than the other types (14444.10 vs 14047.25 and 12243.50), but it was not statistically significant (p>0.05). Estradiol levels correlated significantly (p0.05) with MASI (Melasma Area Severity Index) score and the type of melasma. The study concluded that estradiol levels in women with melasma are higher than not melasma and in mothers with type mix melasma were higher than other types, but not statistically significant. Estradiol level correlated with maternal age and gestational age.},
 year = {2016}
}

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