Prognostic Value of Endothelin-1 Level in Diabetic Patients with Coronary Artery Disease
American Journal of Clinical and Experimental Medicine
Volume 8, Issue 2, March 2020, Pages: 20-25
Received: Feb. 28, 2020;
Accepted: Mar. 13, 2020;
Published: May 28, 2020
Views 332 Downloads 88
Mostafa Attia Eldegwi, Cardiology Department, Shibin Elkom Teaching Hospital, General Organization of Teaching Hospitals and Institutes, Ministry of Health, Shibin Elkom, Egypt
Waleed Abdou Ibrahim, Cardiology Department, Faculty of Medicine, Minoufia University, Shibin Elkom, Egypt
Ibrahim Shehata Elmadbouh, Biochemistry Department, Faculty of Medicine, Minoufia University, Shibin Elkom, Egypt
Ahmed Abdullah Mostafa, Cardiology Department, Police Academic Hospital, Minstry of Interior, Cairo, Egypt
Abdullah Mostafa Kamal, Cardiology Department, Faculty of Medicine, Minoufia University, Shibin Elkom, Egypt
Follow on us
Objective: The aim of this work is to study the prognostic value of the plasma level of the new marker, endothelin-1 (ET-1), in diabetic patients with coronary artery disease. Background: Endothelin 1 (ET-1) has been demonstrated to play a role in endothelial dysfunction and inflammation, both of which are actively involved in the pathophysiology of the onset and progression of coronary artery disease (CAD). Diabetes mellitus increases the risk of CAD and has unfavorable effects on the vascular endothelium, hence the importance of assessing this plasma marker and its relation to the severity of CAD in diabetic patients. Patients & method: This is a cross sectional study in which data was collected from January 2019 to December 2019 and was carried out on patients selected from catheterization laboratory, faculty of medicine, Minoufia university hospital, Egypt. A total of seventy patients, 35 diabetics (groupI, GI) and 35 non-diabetics (groupII, GII), with coronary artery lesions of not less than 50% in at least one main coronary artery plus twenty patients with normal coronaries as a control group (groupIII, GIII) were enrolled. The severity of coronary artery lesions were assessed by GINSINI score (GS) and the relationship between ET-1 level and GS was evaluated. Results: The ET-1 levels were significantly higher in GI with higher GS values of 34.29+ 11.7 points and SYNTAX scores of 18.4+11.17 points, than in GII with lower GS values of 23.23+8.14 points and SYNTAX of scores 12.06+12.11 points (ET-1 was 187.93+146.61 ng/L in GI versus 76.30+91.83ng/L in GII, P value=0.001). ET-1 levels were significantly higher in GI than in GIII (187.93+146.61ng/L versus 26.16+7.32 ng/L, P value=0.001). ET-1 levels were significantly higher in GII than in GIII (76.30+91.83 ng/L versus 26.16+7.32 ng/L, P value=0.001). Conclusion: There is a positive correlation between DM and both ET-1 levels and the severity of coronary artery lesions, P value 0.001.
Plasma Endothelin-1, Coronay Artery Disease, Risk Factors
To cite this article
Mostafa Attia Eldegwi,
Waleed Abdou Ibrahim,
Ibrahim Shehata Elmadbouh,
Ahmed Abdullah Mostafa,
Abdullah Mostafa Kamal,
Prognostic Value of Endothelin-1 Level in Diabetic Patients with Coronary Artery Disease, American Journal of Clinical and Experimental Medicine.
Vol. 8, No. 2,
2020, pp. 20-25.
Copyright © 2020 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/
) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Roger VL: Epidemiology of myocardial infarction. Med Clin North Am, 2007; 91: 537-552.
Hong Lf, Li XL, Luo SH: Association of fibrinogen with severity of stable coronary artery disease in patients with type 2 diabetes mellitus. Dis Markers, 2014: 485687.
Kolettis TM, Barton M, Langleben D: Endothelin in coronary artery disease and myocardial infarction. CardioL Rev, 2013; 21: 249-256.
Khimji AK, Rockey DC: Review: Endothelin-Biology and disease. Cell Signal, 2010; 22: 1615-1625.
Freixa X, Hears M, Ortiz JT: Usefullness of endothelin-1 assessment in acute myocardial infarction. Revista Espanola de Cardiologia (English Edition), 2011; 64: 105-110.
Lebeau R, Serri K, Lorenzo MD, Sauvé C, Le VHV, Soulières V, El-Rayes M, Pagé M, Zaïani C, Garot J, Poulin F. Assessment of LVEF using a new 16-segment wall motion score in echocardiography. (2018) Echo research and practice. 5 (2): 63-69. doi: 10.1530/ERP-18-0006 - Pubmed.
Chap T. Le, Lynn. E. Eberly: Introduction to biostatistics second edition (2016).
Wesson D, Simoni J, Green DF. Reduced extracellular pH increases endothelin-1 secretion by human renal micro-vascular endothelial cells. J Clin Invest 1998; 101: 578-83.
Zeiher AM, Goebel H, Schachinger V, Ihling C. Tissue endothelin-1 immunoreactivity in the active coronary atherosclerotic plaque. A clue to the mechanism of increased vasoreactivity of the culprit lesion in unstable angina. Circulation 2012; 91: 941-7.
Vanhoutte PM. How to assess endothelial function in human blood vessels. J Hypertens 1999; 17: 1047-1058.
Zeiher AM, Drexler H, Wollschlager H, Just H. Modulation of coronary vasomotor tone in humans: Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation 2009; 83: 391–401.
Lin CL, Dumont AS, Wu SC, Wang CJ, Howng SL, Huang YF, et al. 17beta-estradiol inhibits endothelin-1 production and attenuates cerebral vasospasm after experimental subarachnoid hemorrhage. Exp Biol Med (Maywood) 2006; 231: 1054–7.
Novo G, Sansone A, Rizzo M, Guarneri FP, Pernice C, Novo S. High plasma levels of endothelin-1 enhance the predictive value of preclinical atherosclerosis for future cerebrovascular and cardiovascular events: a 20-year prospective study. J Cardiovasc Med (Hagerstown) 2014; 15: 696–701. doi: 10.2459/JCM.
Hellgren MI, Daka B, Jansson PA, Lindblad U, Larsson CA. Insulin resistance predicts early cardiovascular morbidity in men without diabetes mellitus, with effect modification by physical activity. Eur J Prev Cardiol. 2015; 22 (7): 940–9. doi: 10.1177/2047487314537917.
Ding D, Starke RM, Dumont AS, Owens GK, Hasan DM, Chalouhi N, et al. Therapeutic implications of estrogen for cerebral vasospasm and delayed cerebral ischemia induced by aneurysmal subarachnoid hemorrhage. Biomed Res Int. 2014; 2014: 727428.