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Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats
American Journal of Clinical and Experimental Medicine
Volume 6, Issue 3, May 2018, Pages: 64-68
Received: Mar. 26, 2018; Accepted: Apr. 12, 2018; Published: May 24, 2018
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Baozhong Diao, Department of Formulation Branch, Liaocheng People's Hospital, Liaocheng, China
Weirong Jin, Department of Formulation Branch, Liaocheng People's Hospital, Liaocheng, China
Feng E. Zhang, Department of Emergency, Liaocheng People's Hospital, Liaocheng, China
Wenzhou Zhang, Department of Pharmacy, Liaocheng People's Hospital, Liaocheng, China
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objective: The present study aimed to evaluate the therapeutic effects of ketangmin (KTM) on streptozotocin-(STZ) induced diabetic symptoms and their potential mechanisms. Methods: The effect of KTM on body weight, blood glucose, damaged pancreafic β-cells, oxidative stresses, proinflammatory cytokines, and glucose metabolizing enzymes in liver was studied. Results: The results show that administration of KTM can restore abnormal oxidative indices near normal levels. The STZ-damaged pancreatic β-cells of the rats were partly recovered gradually after the mice were administered with KTM 6 weeks later. Therefore, we may assume that KTM is effective in the protection of STZ-induced diabetic rats and KTM may be of use as antihyperglycemic agent.
Ketangmin (KTM), Streptozotocin-Induced Diabetic Symptoms, Potential Mechanisms
To cite this article
Baozhong Diao, Weirong Jin, Feng E. Zhang, Wenzhou Zhang, Protective Effect of KTMon Streptozotocin-Induced Diabetic Symptoms and Their Potential Mechanisms in Rats, American Journal of Clinical and Experimental Medicine. Vol. 6, No. 3, 2018, pp. 64-68. doi: 10.11648/j.ajcem.20180603.11
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This article is an open access article distributed under the Creative Commons Attribution License ( which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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