American Journal of Clinical and Experimental Medicine

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Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors

Received: 27 December 2017    Accepted:     Published: 29 December 2017
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Abstract

The semaphorin family has been demonstrated to possess tumor suppressor activity; semaphorin 3B (SEMA3B) is differentially expressed in several types of tumors, and has been identified as a tumor suppressor gene. SEMA3B is shown to be a target gene of p53, and it suppresses tumor growth through the p53 signaling pathway. The mechanisms underlying tumor suppression by SEMA3B include neuropilin receptors (NRP1 and NRP2), which reduce the action of vascular endothelial growth factor (VEGF), thus, inhibiting tumor angiogenesis. Deficiency or down-regulation of SEMA3B expression can be found in a variety of malignant tumors including lung cancer, ovarian cancer, nervous system tumors, and hepatobiliary tumors, and this suppression involves methylation, loss of heterozygosity (LOH) and enzyme cleavage. This review summarizes recent research approaches on the tumor suppression effects and mechanisms of SEMA3B.

DOI 10.11648/j.ajcem.20170506.18
Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 6, November 2017)
Page(s) 234-238
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Semaphorin 3B, p53, Malignant Tumor, Tumor Suppression, Mechanism

References
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Author Information
  • Department of Radiation Oncology, Changzhou Tumor Hospital, Soochow University, Changzhou, China

  • Department of Radiation Oncology, Changzhou Tumor Hospital, Soochow University, Changzhou, China

  • Department of Radiation Oncology, Changzhou Tumor Hospital, Soochow University, Changzhou, China

Cite This Article
  • APA Style

    Yan Ma, Mingming Fang, Xifa Zhou. (2017). Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors. American Journal of Clinical and Experimental Medicine, 5(6), 234-238. https://doi.org/10.11648/j.ajcem.20170506.18

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    ACS Style

    Yan Ma; Mingming Fang; Xifa Zhou. Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors. Am. J. Clin. Exp. Med. 2017, 5(6), 234-238. doi: 10.11648/j.ajcem.20170506.18

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    AMA Style

    Yan Ma, Mingming Fang, Xifa Zhou. Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors. Am J Clin Exp Med. 2017;5(6):234-238. doi: 10.11648/j.ajcem.20170506.18

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  • @article{10.11648/j.ajcem.20170506.18,
      author = {Yan Ma and Mingming Fang and Xifa Zhou},
      title = {Semaphorin 3B Gene Suppresses Tumor Growth Through the p53 Signaling Pathway and Neuropilin Receptors},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {5},
      number = {6},
      pages = {234-238},
      doi = {10.11648/j.ajcem.20170506.18},
      url = {https://doi.org/10.11648/j.ajcem.20170506.18},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20170506.18},
      abstract = {The semaphorin family has been demonstrated to possess tumor suppressor activity; semaphorin 3B (SEMA3B) is differentially expressed in several types of tumors, and has been identified as a tumor suppressor gene. SEMA3B is shown to be a target gene of p53, and it suppresses tumor growth through the p53 signaling pathway. The mechanisms underlying tumor suppression by SEMA3B include neuropilin receptors (NRP1 and NRP2), which reduce the action of vascular endothelial growth factor (VEGF), thus, inhibiting tumor angiogenesis. Deficiency or down-regulation of SEMA3B expression can be found in a variety of malignant tumors including lung cancer, ovarian cancer, nervous system tumors, and hepatobiliary tumors, and this suppression involves methylation, loss of heterozygosity (LOH) and enzyme cleavage. This review summarizes recent research approaches on the tumor suppression effects and mechanisms of SEMA3B.},
     year = {2017}
    }
    

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    AU  - Mingming Fang
    AU  - Xifa Zhou
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    JO  - American Journal of Clinical and Experimental Medicine
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    PB  - Science Publishing Group
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    AB  - The semaphorin family has been demonstrated to possess tumor suppressor activity; semaphorin 3B (SEMA3B) is differentially expressed in several types of tumors, and has been identified as a tumor suppressor gene. SEMA3B is shown to be a target gene of p53, and it suppresses tumor growth through the p53 signaling pathway. The mechanisms underlying tumor suppression by SEMA3B include neuropilin receptors (NRP1 and NRP2), which reduce the action of vascular endothelial growth factor (VEGF), thus, inhibiting tumor angiogenesis. Deficiency or down-regulation of SEMA3B expression can be found in a variety of malignant tumors including lung cancer, ovarian cancer, nervous system tumors, and hepatobiliary tumors, and this suppression involves methylation, loss of heterozygosity (LOH) and enzyme cleavage. This review summarizes recent research approaches on the tumor suppression effects and mechanisms of SEMA3B.
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