Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats

Lubov Salijanovna Kuchkarova; Dustmatova Gulnara Abdurashidovna

doi:doi:10.11648/j.ajcem.20170505.11

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Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats

Lubov Salijanovna Kuchkarova, Dustmatova Gulnara Abdurashidovna

Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 5)

Received: 28 February 2017 Accepted: 10 April 2017 Published: 16 August 2017

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Abstract

The study is conducted to reveal the effect of oral insulin on the development of carbohydrate hydrolysis and transport in the small intestine in suckling rats. Oral insulin administration (5 U/kg/day) from the 1^st to the 21^st day of postnatal life resulted in induction of the carbohydrate assimilation in the small intestine of growing rats. Oral insulin increased intestinal maltase, sucrase and lactase activity as well as absorption of free and hydrolysis-dependent glucose from maltose in the small intestine of suckling rats. The effect was age-dependent and was clearly expressed during the second half of the milk nutrition period. After weaning oral insulin effect on the intestinal carbohydrate digestion and absorption was absent. These data show oral insulin keeps its biological activity in the intestinal cavity and they suggest involvement of milk insulin in the hydrolysis and absorption of carbohydrates in the small intestine.

Published in	American Journal of Clinical and Experimental Medicine (Volume 5, Issue 5)
DOI	10.11648/j.ajcem.20170505.11
Page(s)	157-161
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Oral Insulin, Disaccharidases, Glucose Absorption, Small Intestine, Suckling Rats

References

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APA Style

Lubov Salijanovna Kuchkarova, Dustmatova Gulnara Abdurashidovna. (2017). Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats. American Journal of Clinical and Experimental Medicine, 5(5), 157-161. https://doi.org/10.11648/j.ajcem.20170505.11

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ACS Style

Lubov Salijanovna Kuchkarova; Dustmatova Gulnara Abdurashidovna. Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats. Am. J. Clin. Exp. Med. 2017, 5(5), 157-161. doi: 10.11648/j.ajcem.20170505.11

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AMA Style

Lubov Salijanovna Kuchkarova, Dustmatova Gulnara Abdurashidovna. Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats. Am J Clin Exp Med. 2017;5(5):157-161. doi: 10.11648/j.ajcem.20170505.11

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@article{10.11648/j.ajcem.20170505.11,
  author = {Lubov Salijanovna Kuchkarova and Dustmatova Gulnara Abdurashidovna},
  title = {Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {5},
  pages = {157-161},
  doi = {10.11648/j.ajcem.20170505.11},
  url = {https://doi.org/10.11648/j.ajcem.20170505.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170505.11},
  abstract = {The study is conducted to reveal the effect of oral insulin on the development of carbohydrate hydrolysis and transport in the small intestine in suckling rats. Oral insulin administration (5 U/kg/day) from the 1st to the 21st day of postnatal life resulted in induction of the carbohydrate assimilation in the small intestine of growing rats. Oral insulin increased intestinal maltase, sucrase and lactase activity as well as absorption of free and hydrolysis-dependent glucose from maltose in the small intestine of suckling rats. The effect was age-dependent and was clearly expressed during the second half of the milk nutrition period. After weaning oral insulin effect on the intestinal carbohydrate digestion and absorption was absent. These data show oral insulin keeps its biological activity in the intestinal cavity and they suggest involvement of milk insulin in the hydrolysis and absorption of carbohydrates in the small intestine.},
 year = {2017}
}

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TY  - JOUR
T1  - Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats
AU  - Lubov Salijanovna Kuchkarova
AU  - Dustmatova Gulnara Abdurashidovna
Y1  - 2017/08/16
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170505.11
DO  - 10.11648/j.ajcem.20170505.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 157
EP  - 161
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170505.11
AB  - The study is conducted to reveal the effect of oral insulin on the development of carbohydrate hydrolysis and transport in the small intestine in suckling rats. Oral insulin administration (5 U/kg/day) from the 1st to the 21st day of postnatal life resulted in induction of the carbohydrate assimilation in the small intestine of growing rats. Oral insulin increased intestinal maltase, sucrase and lactase activity as well as absorption of free and hydrolysis-dependent glucose from maltose in the small intestine of suckling rats. The effect was age-dependent and was clearly expressed during the second half of the milk nutrition period. After weaning oral insulin effect on the intestinal carbohydrate digestion and absorption was absent. These data show oral insulin keeps its biological activity in the intestinal cavity and they suggest involvement of milk insulin in the hydrolysis and absorption of carbohydrates in the small intestine.
VL  - 5
IS  - 5
ER  -

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Author Information

Lubov Salijanovna Kuchkarova

Department of Physiology and Neurobiology, National University of Uzbekistan, Tashkent, Uzbekistan
Dustmatova Gulnara Abdurashidovna

Department of Physiology and Neurobiology, National University of Uzbekistan, Tashkent, Uzbekistan

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APA Style

Lubov Salijanovna Kuchkarova, Dustmatova Gulnara Abdurashidovna. (2017). Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats. American Journal of Clinical and Experimental Medicine, 5(5), 157-161. https://doi.org/10.11648/j.ajcem.20170505.11

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ACS Style

Lubov Salijanovna Kuchkarova; Dustmatova Gulnara Abdurashidovna. Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats. Am. J. Clin. Exp. Med. 2017, 5(5), 157-161. doi: 10.11648/j.ajcem.20170505.11

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AMA Style

Lubov Salijanovna Kuchkarova, Dustmatova Gulnara Abdurashidovna. Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats. Am J Clin Exp Med. 2017;5(5):157-161. doi: 10.11648/j.ajcem.20170505.11

Copy | Download

@article{10.11648/j.ajcem.20170505.11,
  author = {Lubov Salijanovna Kuchkarova and Dustmatova Gulnara Abdurashidovna},
  title = {Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {5},
  pages = {157-161},
  doi = {10.11648/j.ajcem.20170505.11},
  url = {https://doi.org/10.11648/j.ajcem.20170505.11},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170505.11},
  abstract = {The study is conducted to reveal the effect of oral insulin on the development of carbohydrate hydrolysis and transport in the small intestine in suckling rats. Oral insulin administration (5 U/kg/day) from the 1st to the 21st day of postnatal life resulted in induction of the carbohydrate assimilation in the small intestine of growing rats. Oral insulin increased intestinal maltase, sucrase and lactase activity as well as absorption of free and hydrolysis-dependent glucose from maltose in the small intestine of suckling rats. The effect was age-dependent and was clearly expressed during the second half of the milk nutrition period. After weaning oral insulin effect on the intestinal carbohydrate digestion and absorption was absent. These data show oral insulin keeps its biological activity in the intestinal cavity and they suggest involvement of milk insulin in the hydrolysis and absorption of carbohydrates in the small intestine.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Effect of Oral Insulin on the Development of Small Intestine Carbohydrate Hydrolysis and Absorption in Suckling Rats
AU  - Lubov Salijanovna Kuchkarova
AU  - Dustmatova Gulnara Abdurashidovna
Y1  - 2017/08/16
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170505.11
DO  - 10.11648/j.ajcem.20170505.11
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 157
EP  - 161
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170505.11
AB  - The study is conducted to reveal the effect of oral insulin on the development of carbohydrate hydrolysis and transport in the small intestine in suckling rats. Oral insulin administration (5 U/kg/day) from the 1st to the 21st day of postnatal life resulted in induction of the carbohydrate assimilation in the small intestine of growing rats. Oral insulin increased intestinal maltase, sucrase and lactase activity as well as absorption of free and hydrolysis-dependent glucose from maltose in the small intestine of suckling rats. The effect was age-dependent and was clearly expressed during the second half of the milk nutrition period. After weaning oral insulin effect on the intestinal carbohydrate digestion and absorption was absent. These data show oral insulin keeps its biological activity in the intestinal cavity and they suggest involvement of milk insulin in the hydrolysis and absorption of carbohydrates in the small intestine.
VL  - 5
IS  - 5
ER  -

Copy | Download