Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis

Xinan Wang; Donghui Tian; Jianfang Wang; Xiuhe Ouyang

doi:doi:10.11648/j.ajcem.20170501.15

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Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis

Xinan Wang, Donghui Tian, Jianfang Wang, Xiuhe Ouyang

Published in American Journal of Clinical and Experimental Medicine (Volume 5, Issue 1)

Received: 9 February 2017 Accepted: Published: 10 February 2017

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Abstract

Subheading: Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD. Objective: The research aims to quantitatively evaluate the serum MMP-9, inhibitors of TIMP-1, TNF-α, and OPG/RANK/RANKL in the patients with COPD accompanied by osteoporosis. Method: We selected 90 male patients with stable phase COPD who received treatment in our hospital from September 2012 to May 2014. They were divided into three groups by bone mineral density (BMD), COPD normal bone mass group, low bone mass group, and osteoporosis group of 30 patients each. MMP-9, TIMP-1, TNF-α, and OPG/RANK/RANKL were detected with the ELISA method. The ELISA method was used to detect the levels of serum bone alkaline phosphatase (sBAP), serum osteocalcin (sOC), serum type I collagen cross-linked C telopeptide (sCTX). Result: There were significant differences in BMI and CAT scores between the osteoporosis group, the normal bone mass group, and the low bone mass group (P<0.01). The bone density of lumbar vertebra in the low bone mass group and the osteoporosis group decreased when compared with that in the normal bone mass group. The differences were statistically significant (P<0.05, P<0.01). The density of femoral neck in the low bone mass group and the osteoporosis group was significantly lower than that in the normal bone mass group. And there were significant differences (P<0.01). There were significant differences in level of serum MMP-9 among the three groups (P<0.01). Conclusion: MMP-9, TNF-α, and OPG/RANK/RANKL may play a collaborative role in occurrence and progression of pulmonary parenchyma damage and osteoporosis.

Published in	American Journal of Clinical and Experimental Medicine (Volume 5, Issue 1)
DOI	10.11648/j.ajcem.20170501.15
Page(s)	19-25
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Chronic Obstructive Pulmonary Disease, Bone Mineral Density, Osteoporosis, Matrix Metalloproteinase

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APA Style

Xinan Wang, Donghui Tian, Jianfang Wang, Xiuhe Ouyang. (2017). Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis. American Journal of Clinical and Experimental Medicine, 5(1), 19-25. https://doi.org/10.11648/j.ajcem.20170501.15

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ACS Style

Xinan Wang; Donghui Tian; Jianfang Wang; Xiuhe Ouyang. Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis. Am. J. Clin. Exp. Med. 2017, 5(1), 19-25. doi: 10.11648/j.ajcem.20170501.15

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AMA Style

Xinan Wang, Donghui Tian, Jianfang Wang, Xiuhe Ouyang. Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis. Am J Clin Exp Med. 2017;5(1):19-25. doi: 10.11648/j.ajcem.20170501.15

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@article{10.11648/j.ajcem.20170501.15,
  author = {Xinan Wang and Donghui Tian and Jianfang Wang and Xiuhe Ouyang},
  title = {Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {1},
  pages = {19-25},
  doi = {10.11648/j.ajcem.20170501.15},
  url = {https://doi.org/10.11648/j.ajcem.20170501.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170501.15},
  abstract = {Subheading: Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD. Objective: The research aims to quantitatively evaluate the serum MMP-9, inhibitors of TIMP-1, TNF-α, and OPG/RANK/RANKL in the patients with COPD accompanied by osteoporosis. Method: We selected 90 male patients with stable phase COPD who received treatment in our hospital from September 2012 to May 2014. They were divided into three groups by bone mineral density (BMD), COPD normal bone mass group, low bone mass group, and osteoporosis group of 30 patients each. MMP-9, TIMP-1, TNF-α, and OPG/RANK/RANKL were detected with the ELISA method. The ELISA method was used to detect the levels of serum bone alkaline phosphatase (sBAP), serum osteocalcin (sOC), serum type I collagen cross-linked C telopeptide (sCTX). Result: There were significant differences in BMI and CAT scores between the osteoporosis group, the normal bone mass group, and the low bone mass group (PConclusion: MMP-9, TNF-α, and OPG/RANK/RANKL may play a collaborative role in occurrence and progression of pulmonary parenchyma damage and osteoporosis.},
 year = {2017}
}

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TY  - JOUR
T1  - Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis
AU  - Xinan Wang
AU  - Donghui Tian
AU  - Jianfang Wang
AU  - Xiuhe Ouyang
Y1  - 2017/02/10
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170501.15
DO  - 10.11648/j.ajcem.20170501.15
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 19
EP  - 25
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170501.15
AB  - Subheading: Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD. Objective: The research aims to quantitatively evaluate the serum MMP-9, inhibitors of TIMP-1, TNF-α, and OPG/RANK/RANKL in the patients with COPD accompanied by osteoporosis. Method: We selected 90 male patients with stable phase COPD who received treatment in our hospital from September 2012 to May 2014. They were divided into three groups by bone mineral density (BMD), COPD normal bone mass group, low bone mass group, and osteoporosis group of 30 patients each. MMP-9, TIMP-1, TNF-α, and OPG/RANK/RANKL were detected with the ELISA method. The ELISA method was used to detect the levels of serum bone alkaline phosphatase (sBAP), serum osteocalcin (sOC), serum type I collagen cross-linked C telopeptide (sCTX). Result: There were significant differences in BMI and CAT scores between the osteoporosis group, the normal bone mass group, and the low bone mass group (PConclusion: MMP-9, TNF-α, and OPG/RANK/RANKL may play a collaborative role in occurrence and progression of pulmonary parenchyma damage and osteoporosis.
VL  - 5
IS  - 1
ER  -

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Author Information

Xinan Wang

Department of Internal Respiratory, Binzhou People's Hospital, Binzhou, P. R. China
Donghui Tian

Department of Internal Neurology, Binzhou People's Hospital, Binzhou, P. R. China
Jianfang Wang

Department of Public Health, Binzhou People's Hospital, Binzhou, P. R. China
Xiuhe Ouyang

Department of Internal Respiratory, Binzhou People's Hospital, Binzhou, P. R. China

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APA Style

Xinan Wang, Donghui Tian, Jianfang Wang, Xiuhe Ouyang. (2017). Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis. American Journal of Clinical and Experimental Medicine, 5(1), 19-25. https://doi.org/10.11648/j.ajcem.20170501.15

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ACS Style

Xinan Wang; Donghui Tian; Jianfang Wang; Xiuhe Ouyang. Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis. Am. J. Clin. Exp. Med. 2017, 5(1), 19-25. doi: 10.11648/j.ajcem.20170501.15

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AMA Style

Xinan Wang, Donghui Tian, Jianfang Wang, Xiuhe Ouyang. Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis. Am J Clin Exp Med. 2017;5(1):19-25. doi: 10.11648/j.ajcem.20170501.15

Copy | Download

@article{10.11648/j.ajcem.20170501.15,
  author = {Xinan Wang and Donghui Tian and Jianfang Wang and Xiuhe Ouyang},
  title = {Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis},
  journal = {American Journal of Clinical and Experimental Medicine},
  volume = {5},
  number = {1},
  pages = {19-25},
  doi = {10.11648/j.ajcem.20170501.15},
  url = {https://doi.org/10.11648/j.ajcem.20170501.15},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajcem.20170501.15},
  abstract = {Subheading: Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD. Objective: The research aims to quantitatively evaluate the serum MMP-9, inhibitors of TIMP-1, TNF-α, and OPG/RANK/RANKL in the patients with COPD accompanied by osteoporosis. Method: We selected 90 male patients with stable phase COPD who received treatment in our hospital from September 2012 to May 2014. They were divided into three groups by bone mineral density (BMD), COPD normal bone mass group, low bone mass group, and osteoporosis group of 30 patients each. MMP-9, TIMP-1, TNF-α, and OPG/RANK/RANKL were detected with the ELISA method. The ELISA method was used to detect the levels of serum bone alkaline phosphatase (sBAP), serum osteocalcin (sOC), serum type I collagen cross-linked C telopeptide (sCTX). Result: There were significant differences in BMI and CAT scores between the osteoporosis group, the normal bone mass group, and the low bone mass group (PConclusion: MMP-9, TNF-α, and OPG/RANK/RANKL may play a collaborative role in occurrence and progression of pulmonary parenchyma damage and osteoporosis.},
 year = {2017}
}

Copy | Download

TY  - JOUR
T1  - Research on the Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD Accompanied by Osteoporosis
AU  - Xinan Wang
AU  - Donghui Tian
AU  - Jianfang Wang
AU  - Xiuhe Ouyang
Y1  - 2017/02/10
PY  - 2017
N1  - https://doi.org/10.11648/j.ajcem.20170501.15
DO  - 10.11648/j.ajcem.20170501.15
T2  - American Journal of Clinical and Experimental Medicine
JF  - American Journal of Clinical and Experimental Medicine
JO  - American Journal of Clinical and Experimental Medicine
SP  - 19
EP  - 25
PB  - Science Publishing Group
SN  - 2330-8133
UR  - https://doi.org/10.11648/j.ajcem.20170501.15
AB  - Subheading: Role of Matrix Metalloproteinase in the Patients with Stable Phase COPD. Objective: The research aims to quantitatively evaluate the serum MMP-9, inhibitors of TIMP-1, TNF-α, and OPG/RANK/RANKL in the patients with COPD accompanied by osteoporosis. Method: We selected 90 male patients with stable phase COPD who received treatment in our hospital from September 2012 to May 2014. They were divided into three groups by bone mineral density (BMD), COPD normal bone mass group, low bone mass group, and osteoporosis group of 30 patients each. MMP-9, TIMP-1, TNF-α, and OPG/RANK/RANKL were detected with the ELISA method. The ELISA method was used to detect the levels of serum bone alkaline phosphatase (sBAP), serum osteocalcin (sOC), serum type I collagen cross-linked C telopeptide (sCTX). Result: There were significant differences in BMI and CAT scores between the osteoporosis group, the normal bone mass group, and the low bone mass group (PConclusion: MMP-9, TNF-α, and OPG/RANK/RANKL may play a collaborative role in occurrence and progression of pulmonary parenchyma damage and osteoporosis.
VL  - 5
IS  - 1
ER  -

Copy | Download