American Journal of Clinical and Experimental Medicine

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Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination

Received: 13 August 2016    Accepted: 01 September 2016    Published: 21 September 2016
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Abstract

Fecundability increases when ovulation induction was conducted before starting intrauterine insemination procedure (IUI). Human Menopousal gonadotrophin (HMG) and recombinant follicle stimulating hormone (rFSH) are gonadotropin hormones that are widely used in the stimulation of ovulation in infertile patients. Although comparison of gonadotropin preparations have been carried out in IVF, but comparison of rFSH preparations and HMG on IUI was still lacking. The aim of this study was to compare rFSH and HMG, each was combined with clomiphene citrate in infertile women undergone intrauterine insemination (IUI). This study was a retrospective study in the Department of Obstetrics and Gynecology Wahidin Sudirohusodo. Samples were infertile patients who meet these following criteria: women aged 20-45 years, infertility of unknown cause for approximately 12 months, had a history of induced ovulation for approximately 6 cycles without IUI, IVF or ICSI, patent tubes examined with hysterosalpingography, and normal semen analysis according to 1999 WHO criteria. A total of 78 patients consisted of 30 patients using clomiphene citrate + rFSH and 48 other patients using clomiphene citrate + HMG. In two groups, total dosage, duration of gonadotropin administration, follicle count, mean size of follicles, endometrial line size and pregnancy were compared. Statistical test using Levene T and unpaired t test was conducted using SPSS 16 for Windows version. There was no statistically significant difference among total dosage, duration of gonadotropins administration, follicle counts, mean size of follicles, and endometrial line size. The mean number of pregnancy was higher in patients treated with clomiphene citrate + hMG but this difference was not statistically significant. hMG and rFSH was equally effective in stimulating ovulation in intrauterine insemination.

DOI 10.11648/j.ajcem.20160405.14
Published in American Journal of Clinical and Experimental Medicine (Volume 4, Issue 5, September 2016)
Page(s) 134-137
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

Ovulation Stimulation, Intrauterine Insemination, HMG, rFSH

References
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[3] Sperrof L, Fritz MA. Clinical gynecologic endocrinology and infertility. 8th ed. Philadelpia: Lippincot Williams and Wilkins; 2011. p. 2337-2341.
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[8] Beall SA, DeCherney A. History and challenges surrounding ovarian stimulation in the treatment of infertility. Fertil Steril 2012; 97: 795-801.
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[10] Bjercke S, Tanbo T, Abyholm T, Omland A, Opoien HK, Fedorcsak P. Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing their first treatment cycle of IVF or ICSI. Acta Obstet Gynecol Scand 2010; 89: 1053–60.
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[12] Ye H, Huang G, Pei L, Zeng P, Luo X. Outcome of in vitro fertilization following stimulation with highly purified hMG or recombinant FSH in downregulated women of advanced reproductive age: a prospective, randomized and controlled trial. Gynecol Endocrinol 2012; 28: 540–44.
[13] Kilani Z, Dakkak A, Ghunaim S, Cognigni GE, Tabarelli C, Parmegiani L et al. A prospective, randomized, controlled trial comparing HP-hMG with r- FSH in women undergoing ICSI: ovarian response and clinical outcomes. Hum Reprod 2003; 18: 1194–9.
[14] Al-Inany H, Aboulghar M, Mansour R, Serour G. Meta-analysis of recombinant versus urinary derived FSH: an update. Hum Reprod 2003; 18: 305-13.
[15] Al-Inany H, Aboulghra MA, Mansour RT, Seour GI. Ovulation induction in the new millennium: recombinant follicle stimulating hormone versus human menopausal gonadotropin. Gynecol Endocrinol 2005; 20: 161-9.
[16] Van Wely M, Westergaard LG, Bossuyt PM, Van der Veen F. Human Menopousal Gonadotropin versus recombinant Follicle Stimulation hormone for ovarian stimulation in assisted reproductive cycles. Cochrane Database Syst Rev 2011; 16.
[17] Al-Inany HG, Abou-Setta AM, Aboulghar MA, Monsour RT, Serour GI. Efficacy and safety of human menopausal gonadotropins versus recombinant FSH: a meta-analysis. RBM Online 2008; 16: 81-8.
[18] Rashidi, Mandana, et al. Advantages of recombinant FSH over human menopausal gonadatropin for ovarian stimulation in intrauterine insemination: a randomized clinical trial in unexplained infertility. European Journal of Obstetric and Gynecology and Reproductive Biology 2013; 244-247.
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[24] Platteau P, Andersen AN, Balen A, Devroey P, Sorenson P, Helmgaard L, et al. Similar ovulation rates, but different follicular development with highly purified menotropin compared with r FSH in WHO group II anovulatory infertility: a randomized controlled study. Hum Reprod 2006; 21: 1798-804.
[25] Kocak M, Dilbaz B, Demir B, et al. Lyophilised hMG versus rFSH in women with unexplained infertility undergoing a controlled ovarian stimulation with intrauterine insemination: a prospective, randomized study. Gynecological Endocrinology 2010; 26: 429-434.
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Author Information
  • Department of Obstetrics and Gynecology, Faculty of Medicine, Hasanuddin University, Makassar, South Sulawesi, Indonesia

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    Eddy Hartono. (2016). Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination. American Journal of Clinical and Experimental Medicine, 4(5), 134-137. https://doi.org/10.11648/j.ajcem.20160405.14

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    Eddy Hartono. Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination. Am. J. Clin. Exp. Med. 2016, 4(5), 134-137. doi: 10.11648/j.ajcem.20160405.14

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    AMA Style

    Eddy Hartono. Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination. Am J Clin Exp Med. 2016;4(5):134-137. doi: 10.11648/j.ajcem.20160405.14

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  • @article{10.11648/j.ajcem.20160405.14,
      author = {Eddy Hartono},
      title = {Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination},
      journal = {American Journal of Clinical and Experimental Medicine},
      volume = {4},
      number = {5},
      pages = {134-137},
      doi = {10.11648/j.ajcem.20160405.14},
      url = {https://doi.org/10.11648/j.ajcem.20160405.14},
      eprint = {https://download.sciencepg.com/pdf/10.11648.j.ajcem.20160405.14},
      abstract = {Fecundability increases when ovulation induction was conducted before starting intrauterine insemination procedure (IUI). Human Menopousal gonadotrophin (HMG) and recombinant follicle stimulating hormone (rFSH) are gonadotropin hormones that are widely used in the stimulation of ovulation in infertile patients. Although comparison of gonadotropin preparations have been carried out in IVF, but comparison of rFSH preparations and HMG on IUI was still lacking. The aim of this study was to compare rFSH and HMG, each was combined with clomiphene citrate in infertile women undergone intrauterine insemination (IUI). This study was a retrospective study in the Department of Obstetrics and Gynecology Wahidin Sudirohusodo. Samples were infertile patients who meet these following criteria: women aged 20-45 years, infertility of unknown cause for approximately 12 months, had a history of induced ovulation for approximately 6 cycles without IUI, IVF or ICSI, patent tubes examined with hysterosalpingography, and normal semen analysis according to 1999 WHO criteria. A total of 78 patients consisted of 30 patients using clomiphene citrate + rFSH and 48 other patients using clomiphene citrate + HMG. In two groups, total dosage, duration of gonadotropin administration, follicle count, mean size of follicles, endometrial line size and pregnancy were compared. Statistical test using Levene T and unpaired t test was conducted using SPSS 16 for Windows version. There was no statistically significant difference among total dosage, duration of gonadotropins administration, follicle counts, mean size of follicles, and endometrial line size. The mean number of pregnancy was higher in patients treated with clomiphene citrate + hMG but this difference was not statistically significant. hMG and rFSH was equally effective in stimulating ovulation in intrauterine insemination.},
     year = {2016}
    }
    

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    T1  - Comparison of Human Menopousal Gonadotropin with Recombinant Follicle Stimulating Hormone in Ovulation Stimulation During Intrauterine Insemination
    AU  - Eddy Hartono
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    AB  - Fecundability increases when ovulation induction was conducted before starting intrauterine insemination procedure (IUI). Human Menopousal gonadotrophin (HMG) and recombinant follicle stimulating hormone (rFSH) are gonadotropin hormones that are widely used in the stimulation of ovulation in infertile patients. Although comparison of gonadotropin preparations have been carried out in IVF, but comparison of rFSH preparations and HMG on IUI was still lacking. The aim of this study was to compare rFSH and HMG, each was combined with clomiphene citrate in infertile women undergone intrauterine insemination (IUI). This study was a retrospective study in the Department of Obstetrics and Gynecology Wahidin Sudirohusodo. Samples were infertile patients who meet these following criteria: women aged 20-45 years, infertility of unknown cause for approximately 12 months, had a history of induced ovulation for approximately 6 cycles without IUI, IVF or ICSI, patent tubes examined with hysterosalpingography, and normal semen analysis according to 1999 WHO criteria. A total of 78 patients consisted of 30 patients using clomiphene citrate + rFSH and 48 other patients using clomiphene citrate + HMG. In two groups, total dosage, duration of gonadotropin administration, follicle count, mean size of follicles, endometrial line size and pregnancy were compared. Statistical test using Levene T and unpaired t test was conducted using SPSS 16 for Windows version. There was no statistically significant difference among total dosage, duration of gonadotropins administration, follicle counts, mean size of follicles, and endometrial line size. The mean number of pregnancy was higher in patients treated with clomiphene citrate + hMG but this difference was not statistically significant. hMG and rFSH was equally effective in stimulating ovulation in intrauterine insemination.
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