The Effectiveness of Topical Mangosteen Pericarp Extract on the Collagen of Mice Skin Exposed to Ultraviolet B
American Journal of Clinical and Experimental Medicine
Volume 4, Issue 3, May 2016, Pages: 88-93
Received: May 5, 2016; Accepted: May 23, 2016; Published: Jun. 1, 2016
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Authors
Elfa Wirdani Fitri, Department of Dermatovenereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Anis Irawan Anwar, Department of Dermatovenereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Khairuddin Djawad, Department of Dermatovenereology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Arifin Seweng, Department of Biostatistics, Faculty of Public Health, Hasanuddin University, Makassar, Indonesia
Husni Changara, Department of Anatomical-Pathology, Faculty of Medicine, Hasanuddin University, Makassar, Indonesia
Gemini Alam, Department of Pharmacognosy, Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia
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Abstract
Exposure to ultraviolet B (UVB) has an impact in the form of changes in the dermis collagen fibers and can result in decreasing the thickness and density of collagen. This study aims to assess the effectiveness of mangosteen pericarp extract to the thickness and density of collagen in mice skin after being exposed to UVB. This research was conducted in the animal laboratory and the anatomic pathology laboratory Hasanuddin University, Makassar. The study used pure animal experimental research design with control group. The samples were 24 mice that were divided into four groups: normal, UVB, ethanol and mangosteen groups. Mangosteen pericarp extract with a concentration of 50% was applied shortly after the mice were exposed to UVB. The thickness and density of collagen in normal group was significantly higher than UVB and ethanol groups. Mangosteen groups showed collagen density higher than UVB and ethanol groups. No significant differences between mangosteen and normal group. No significant differences between ethanol and UVB groups. Mangosteen pericarp extract with a concentration of 50% (2 mg / gBW mice) can increase the thickness and density of collagen in mice skin exposed to UVB.
Keywords
Collagen, Mangosteen Pericarp Extract, Mice Skin, Ultraviolet-B
To cite this article
Elfa Wirdani Fitri, Anis Irawan Anwar, Khairuddin Djawad, Arifin Seweng, Husni Changara, Gemini Alam, The Effectiveness of Topical Mangosteen Pericarp Extract on the Collagen of Mice Skin Exposed to Ultraviolet B, American Journal of Clinical and Experimental Medicine. Vol. 4, No. 3, 2016, pp. 88-93. doi: 10.11648/j.ajcem.20160403.19
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Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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