The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes)
American Journal of Clinical and Experimental Medicine
Volume 4, Issue 3, May 2016, Pages: 76-80
Received: Mar. 30, 2016; Accepted: May 9, 2016; Published: May 28, 2016
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Authors
Ma’arifah Nadjar, Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Farida Ilyas, Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Safruddin Amin, Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Farida Tabri, Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
R. Satriono, Pediatric Departement, Medical Faculty Hasanuddin University, Makassar, Indonesia
Rizalinda Sjahrir, Microbiology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
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Abstract
Topical tretinoin is used by the dermatolovenereologist and aesthetic physicians in patients with mild acne vulgaris, so it is necessary to be investigated. The aim of the study was to assess the effectiveness of benzoyl peroxide gel compared to tretinoin gel on persons with mild acne vulgaris and identify Propionibacterium acnes in patients with mild acne vulgaris. The research method was a clinical trial, double blind randomization. Patients with mild acne vulgaris were randomized in to 2 groups, each group was examined for clinical manifestations (comedone, papules or pustules) examination with sebumeter 815 and Polymerase Chain Reaction, every night each group was treated with benzoyl peroxide 5% gel and tretinoin 0.05% gel in the application, and followed-up in the days of the week 2, 4 and 6. Data were processed with Mann-Whitney test and Chi-Square Test. The results indicated benzoyl peroxide 5% gel and tretinoin 0.05% gel have the same effectiveness in patients with mild acne vulgaris. But, benzoyl peroxide 5% gel decreased blackheads faster compared to papules or pustules with 0.05% tretinoin gel. of sebum. There was no difference in levels of decrease between benzoyl peroxide 5% gel and tretinoin 0.05% gel. Propionibacterium acnes were found in patients with mild acne vulgaris before the treatment of benzoyl peroxide 5% gel and tretinoin 0.05% gel, although not found in all samples.
Keywords
Mild Acne Vulgaris, Benzoyl Peroxide 5% Gel, Tretinoin 0.05% Gel
To cite this article
Ma’arifah Nadjar, Farida Ilyas, Safruddin Amin, Farida Tabri, R. Satriono, Rizalinda Sjahrir, The Effectiveness of Benzoyl Peroxide 5% Gel with 0.05% Tretinoin Gel in Patients with Mild Acne Vulgaris (Identification of P. Acnes), American Journal of Clinical and Experimental Medicine. Vol. 4, No. 3, 2016, pp. 76-80. doi: 10.11648/j.ajcem.20160403.17
Copyright
Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
References
[1]
Zaeglein A. et al. Acne vulgaris and acneiform eruptions. In wolf, K. Goldsmith, L, Katz, S. Gilchrest, B, Paller, A. & Leffell, D. Eds. Fitzpatrick’s dermatology in general medicine. New York. 8th ed. 2012. 1264-1290.
[2]
Zaenglein, A. L. Thiboutot, D. M. Acne vulgaris. Dermatology. J. L. Bolognia, J. L. Jorizzo and J. V. Schaffer. USA, elsevier. 2011; 36: 545-559.
[3]
Benner N. & Sammons D. Overview of the treatment of acne vulgaris. Osteophatic Fam Physician J. 2013; 5: 185-190.
[4]
Layton A. M. Disorders of the Sebaceous Glands. Burns T. Breathnach S, Cox N, Griffiths C, editors. Rook's Textbook of Dermatology. 8th ed. Wiley-Blackwell. 2010. p. 42. 17-42.55.
[5]
Kraft, J., Freiman, A. Management of Acne. Canadian Medical Association J. 2011; 183 (7): 430-435.
[6]
Koo, E, B., Petersen, T, D, Kimball, A. B. Meta-Analysis Comparing Efficacy Of Antibiotics Versus Oral Contraceptives In Acne Vulgaris. J Am Acad Dermatol. 2014; 1-9.
[7]
Gollnick H. & Cunliffe W. Management of acne are report from a global alliance to improve outcome in acne. J Am Acad Dermatol. 2003; 49: S1-38.
[8]
Achermann Y. et al. Propionibacterium acnes: from Commensal to Opportunistic Biofilm-Associated Implant Pathogen. Clinical Microbiology Reviews J. 2014; 27: 419–440.
[9]
Ramanathan S. and Hebert A. A. Management of acne vulgaris. J pediatr Health Care. 2011; 25: 332-337.
[10]
Eichenfield L. F. et al. Evidence-Based Recommendations for the Diagnosis and Treatment of Pediatric Acne. Acad Pe J. 2013; 131, 163-182.
[11]
Pappas, A., Johnsen, S., Liu, C. J. Eisinger, M. Sebum analysis Of Individuals with and without Acne. Dermato-endocrinology. 2009; 1: 3. 157-161.
[12]
Wolff K. et al. Topical tretinoin, Fitzpatrick's Dermatology in General Medicine, Ac. 2008; 3789-3797.
[13]
Malhotra N, et al. Real World Acne Therapy in Primary Care. Dermatol J. 2012; 5: 29-43.
[14]
Liao DC. Management of Acne. Fam J Pract. 2003; 52: 43.
[15]
Ramdani R, 1 Sibero, H. T. Treatment for Acne Vulgaris. J Majority. 2015; 4: 87-95.
[16]
Tsatsou F. & Christos. C. Z Acne vulgaris. Treatment of Skin Disease: Comprehensive Therapeutic Strategies. M. G. Lebwohi, W. R. Heymann, J. B.-. jones and I. Coulson. New York, Elsevier. 3. 2014. 6-11.
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