American Journal of Clinical and Experimental Medicine
Volume 4, Issue 2, March 2016, Pages: 30-33
Received: Feb. 8, 2016;
Accepted: Feb. 29, 2016;
Published: Mar. 28, 2016
Views 2828 Downloads 58
Ade Indrayani, Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Andi Muhammad Adam, Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Faridha Ilyas, Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Safruddin Amin, Dermatovenereology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Burhanuddin Bahar, Public Health Faculty Hasanuddin University, Makassar, Indonesia
Rizalinda Sjahrir, Microbiology Department, Medical Faculty Hasanuddin University, Makassar, Indonesia
Investigation of mucosa immunoglobulin A (IgA) can be used to determine the prevalence of Chlamydia trachomatis (CT) infection, in addition to examination of Polymerase Chain Reaction (PCR) particularly in asymptomatic cases. This research is aimed to compare the levels of IgA mucosal urethral in asymptomatic Chlamydia trachomatis infection and non-infection in male prisoners based on PCR examination in the prison. The methods used was urethral swab specimens collected from 43 asymptomatic male prisoners at the Sidrap Prison in December 2015 and then were examined using PCR method, followed by examination of mucosal IgA levels. The results indicate prevalence of CT based on PCR examination is 2.3%. Based on the examination of PCR, mucosal IgA levels in infected by CT six-fold higher than non-infectious with a mean ± SB (4.45) vs (0.77 ± 0.52) with p = 0.09. Based on the examination of mucosal IgA, the level of infected IgA is four-fold higher than non-infectious with a mean ± SB (2.48 ± 1.41) vs (0.64 ± 0.21), with p < 0.001. The combination of a positive PCR results and/or IgA positive with urethral specimen indicate infection of CT, but PCR and IgA in CT infections are not interchangeable but both constitute complementary examination.
Andi Muhammad Adam,
Comparative Levels of Immunoglobulin A Urethral Mucosa in Asymptomatic Chlamydia trachomatis Infections in the Prison, American Journal of Clinical and Experimental Medicine.
Vol. 4, No. 2,
2016, pp. 30-33.
Eley, A. How to detect Chlamydia trachomatisin males? J of Androl. 2011; 32 (1): 15-22.
VaIkengoid, IG, Morre, SA, Brule, AJ, et al. Low diagnostic accuracy of selective screening criteria for asymtomatic Chlamydia trachomatis infection in the general population. Sex Transm Infect. 2000; 76: 375-80.
Louise, MH, Beagley, K., and Timms, P. Chlamydia trachomatis infection: host immune responses and potential vaccine. Mucosal Immunol. 2008; 1 (2): 116-130.
Anderson, DJ Genitourinary immune defense. Holmes, KK, Sparling, PF, Stamm, WE, Piot, P., Wasserheit, JN, Corey, L., Cohen, MS, Watts, DH, editor: Sexually Transmitted Diseases, 4th ed., 2008. New York; McGraw-Hill.
Bernstein, DI and Milligan, GN Mucosal immunity of the Genital Tract. Mestecky, J., Lamm, MF, Strober, W., Bienenstock, J., McGhee, JR, Mayer, L., editor: Mucosal Immunology, 3rd ed. 2005, USA; Elsevier Academic Press.
Steiner, US, Haller, DM, Elger, BS, Seb o, P., Gaspoz, JM, Wolff, H. Chlamydia trachomatis infection in Swiss prison: a cross sectional study. Swiss Med Wkly. 2010; 140: 1-5.
Kouyoumdjian, FG, Main, C., Calzavara, LM, Kiefer, L. Prevalence and predictors of urethral chlamydia and gonorrhea infection in male inmate in an Ontario Corectional Facility. Can J Public Health. 2011; 102 (3): 220-24.
Bernstein, KT, Chow, JM, Ruiz, J., Schachter, J., Horowitz, E., Bunnell, R., Boian, G. Chlamydia trachomatis and Neisseria gonorrhoeae infection Among men and women entering California Prisons. Am J Public Health. 2006; 96: 1862-1866.
Hirst, H. and Dinsmore, WW Chlamydia Screening Programme, HMP Hydebank Wood Young Offender Centre, Belfast, Northern Ireland, UK. Int J of STD & AIDS. 2009; 20: 360-1.
Pate, MS, Hedges, SR, Sibley, DA, Russell, MW, Hook, EW, Mestecky, J. Urethral Cytokines and Immune Responses in -Infected Males Chlamydiatrachomatis. Infection and Immunity. 2001; P7178-81.
Esse-Sorlie, D. Medical Biostatistic and Epidemiology. Connecticut: A Simon and chuster Company. 1995; 71-85.
Simpson, J., Berry, G. Normal Distribution. In: Kerr, C et al. Ed’s. Handbook of Public Health Methods. Sidney. The Mc Graw Hill Company Inc. 1998; 212-216. 70.
Fresse, USA, Sueur, JM, Hamdad, F. Diagnosis and follow-up of genital chlamydial infection by direct methods and by detection of serum IgG, IgA, and secretory IgA. IJMM. 2010; 28 (4): 326-31.
Witkin, SS, Bongiovanni, AM, Inglis, SR Detection of Chlamydia trachomatis Endocervical Anti- Immunoglobulin A in Pregnant Women by a Rapid, 6-Minute Enzyme-Linked Immunosorbent Assay: Comparison with PCR and Chlamydial Antigen Detection Methods. J. Clin. Microbiol. 1997; 35: 1781-3.