Serum Erythropoietin Level in Chronic Kidney Disease Patients with Anemia: A Baseline Study at Chittagong Medical College, Chittagong, Bangladesh
American Journal of Clinical and Experimental Medicine
Volume 4, Issue 2, March 2016, Pages: 20-25
Received: Feb. 11, 2016; Accepted: Feb. 24, 2016; Published: Mar. 17, 2016
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Authors
Mizanur Rahman, Department of Biochemistry, Rangamati Medical College, Rangamati, Bangladesh
Mahmudul Haque, Department of Biochemistry, Chittagong Medical College, Chittagong, Bangladesh
ASM Towhidul Alam, Department of Biochemistry, Cox's Bazar Medical College, Cox's Bazar, Bangladesh
Md. Nurul Amin, Department of Anesthesiology, Sylhet Women’s Medical College, Sylhet, Bangladesh
K. M. Huria Parveen, Department of Biochemistry, Dhaka Medical College, Dhaka, Bangladesh
Naila Al Mahmuda, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan
Md. Golam Abbas, Department of Molecular Neuroscience and Integrative Physiology, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, Ishikawa, Japan; Infectious Diseases Hospital, Dhaka, Bangladesh
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Abstract
Chronic kidney disease (CKD) is a serious condition associated with premature mortality, decreased quality of life, and increased health-care expenditures. A failure to produce sufficient Erythropoietin (EPO) accounts for the moderate to severe anemia observed in chronic kidney disease. Decreased EPO production is attributed to destruction of renal production sites. A cross-sectional descriptive study was designed for determination of erythropoietin level in chronic kidney disease patients with anemia. At the same time measurement of serum iron and serum ferritin to establish anemia. Serum concentration of erythropoietin was the parameter taken to evaluate the kidney status. This study was carried out in the Nephrology ward, Chittagong Medical College Hospital (CMCH), Chittagong, Bangladesh during the period of January 2012 to December 2012. Total Sixty Patients having hemoglobin level < 11 gm/dl and serum creatinine > 3 mg/dl taken as a case of chronic kidney disease with anemia. Mean Hemoglobin level found 8.67gm/dl [± 1.39SD(standard deviation), Serum creatinine level found 8.21 mg/dl (±3.25 SD), Serum erythropoietin level found 2.67 miu (mili international unit)/ml (± 2.36 SD), Serum iron level found 13.78 µg/dl (±2.58 SD). Serum ferritin level found 73.35ng/mL (± 26.81SD). It is also observed that Pearson’s correlation coefficient (r) between erythropoietin and hemoglobin is – 0.190 (r=0.036, p value=0.145), which is not significant. Correlation coefficient between erythropoietin and creatinine is – 0.082 (r=0.007 p value = 0.532), which is not significant. Correlation coefficient between erythropoietin and iron is 0.021 (r=4.549, p value =0.872), which is not significant but shows weakly positive correlation. Correlation coefficient between erythropoietin and ferritin is 0.005 (r=2.723 p value=0.968) which is not significant but also shows weakly positive correlation.
Keywords
Erythropoietin, Iron, Ferritin, Chronic Kidney Disease
To cite this article
Mizanur Rahman, Mahmudul Haque, ASM Towhidul Alam, Md. Nurul Amin, K. M. Huria Parveen, Naila Al Mahmuda, Md. Golam Abbas, Serum Erythropoietin Level in Chronic Kidney Disease Patients with Anemia: A Baseline Study at Chittagong Medical College, Chittagong, Bangladesh, American Journal of Clinical and Experimental Medicine. Vol. 4, No. 2, 2016, pp. 20-25. doi: 10.11648/j.ajcem.20160402.12
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Copyright © 2016 Authors retain the copyright of this article.
This article is an open access article distributed under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
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