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Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection
American Journal of Clinical and Experimental Medicine
Volume 3, Issue 6, November 2015, Pages: 368-371
Received: Dec. 24, 2015; Published: Dec. 30, 2015
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Authors
Jing Zhang, School of Pharmacy, Inner Mongolia Medical University, Hohhot, China
Na Yi, School of Pharmacy, Inner Mongolia Medical University, Hohhot, China
Lidao Bao, School of Pharmacy, Inner Mongolia Medical University, Hohhot, China; Department of Pharmacy, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China
Tengfei Yu, School of Pharmacy, Inner Mongolia Medical University, Hohhot, China
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Abstract
To compare the pharmacokinetics and relative bioavailability of ambroxol hydrochloride (AH) aerosol and injection, the volunteers were subjected to single-dose crossover inhalation (injection) of 100 mg AH aerosol (injection). The drug concentrations in plasma were determined by HPLC. The areas under curve (AUC) of the two formulations were compared by the three-factor analysis of variance and the bi-directional one-side t test. The Cmax, tmax, t1/2β and AUC values of the aerosol group and the injection group were (154.75±26.12) and (157.39±26.09) ng/ml, (1.12±0.34) and (1.29±0.33) h, (6.98±1.62) and (7.75±1.26) h, and (1593.02±290.45) and (1438±132.46) h•ng/ml, respectively. The bioavailabilities of AH aerosol and injection were the same, and the relative bioavailability of the aerosol was (96.52±11.44)%.
Keywords
Ambroxol Hydrochloride, Bioavailability, Pharmacokinetics, HPLC
To cite this article
Jing Zhang, Na Yi, Lidao Bao, Tengfei Yu, Pharmacokinetics and Relative Bioavailability of Ambroxol Hydrochloride Aerosol and Injection, American Journal of Clinical and Experimental Medicine. Vol. 3, No. 6, 2015, pp. 368-371. doi: 10.11648/j.ajcem.20150306.18
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