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Correlation of Serum IL-4 Levels in New and MDR Tuberculosis Patients
American Journal of Clinical and Experimental Medicine
Volume 3, Issue 1, January 2015, Pages: 48-51
Received: Nov. 24, 2014; Accepted: Dec. 17, 2014; Published: Feb. 6, 2015
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Authors
Nazish Fatima, Department of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
Mohammad Shameem, Department of TB & Respiratory Disease, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
Nabeela , Department of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
Parvez A. Khan, Department of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
H. M. Khan, Department of Microbiology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, India
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Abstract
Mycobacterium tuberculosis (Mtb) infects approximately one third of world population. Many cytokines are produced during tuberculosis, with predominance of Th1 cytokines during the early stage and Th2 cytokines in the later stages of the infection. Most studies on cytokines during TB are from ‘in vitro’-stimulated lymphoid cells with few reports on in vivo plasma levels. The high expression of IL-4 has been implicated as a virulence factor. In the present study we examined the level of IL-4 in the serum of active tuberculosis in new cases, during anti-tubercular therapy and MDR cases. This Study was conducted at Department Of Microbiology, JNMC, AMU, Aligarh. A total 76 blood samples of Pulmonary & Extra-Pulmonary tuberculosis patients were tested by ELISA (Diaclone France) along with 10 healthy controls. The test was carried out according to the manufacturer instructions. O.D. was taken at 450 nm. There was no stastical difference in age and sex in our study. The level of IL-4 show significant changes in MDR TB cases (P<0.05) but not significant during the anti-tubercular therapy (ATT) and new TB cases (P>0.05). An understanding of the development of the cellular immune response may lead to insight into pathogenesis and novel therapies for TB. Further studies are needed to address the role of cytokines in immunity to TB under natural conditions.
Keywords
MDR TB, IL-4, Cytokines
To cite this article
Nazish Fatima, Mohammad Shameem, Nabeela , Parvez A. Khan, H. M. Khan, Correlation of Serum IL-4 Levels in New and MDR Tuberculosis Patients, American Journal of Clinical and Experimental Medicine. Vol. 3, No. 1, 2015, pp. 48-51. doi: 10.11648/j.ajcem.20150301.17
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