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Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver
American Journal of Clinical and Experimental Medicine
Volume 3, Issue 1, January 2015, Pages: 24-31
Received: Dec. 31, 2014; Accepted: Jan. 15, 2015; Published: Jan. 28, 2015
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Authors
Ulyana N. Tumanova, Department of Radiological Methods of Diagnosis and Treatment, A.V. Vishnevsky Institute of Surgery, Ministry of Health of Russia, Moscow, Russia; Department of Pathology, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
Grigoriy G. Karmazanovsky, Department of Radiological Methods of Diagnosis and Treatment, A.V. Vishnevsky Institute of Surgery, Ministry of Health of Russia, Moscow, Russia
Alexander I. Shchyogolev, Department of Pathology, Academician V.I. Kulakov Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia, Moscow, Russia
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Abstract
An important CT-characteristic at a diagnostic of liver tumors is the determination of its vascularity. To study the characteristics of blood tissue of hepatocellular carcinoma (HCC) with different degrees of differentiation by CT. The work is based on the clinical and morphological comparisons performed in 55 patients (34 men and 21 women aged 15-83 years) with hepatocellular carcinoma (HCC) without accompanying liver cirrhosis. In the preoperative stage all patients was carried spiral computed tomography (CT) with bolus contrast enhancement (on the four phases of the study). Was evaluated parameters of CT density and degree of nodes HCC vascularization. Morphologic study of histological preparations of operation material from 16 patients was diagnosed high-differentiated, 33 - moderately differentiated, and 6 - poorly differentiated HCC. At the immunohistochemical preparations with reaction to CD34 was determined by the number and the total cross-sectional area of vessels in sight of HCC tissue. The maximum values of CT density in the arterial phase were observed at the nodes moderately differentiated HCC. In the venous phase the greatest values of density as well as the venous increase was registered in high-differentiated HCC. The most vascularised (hypervascular) tumor is high-differentiated HCC, and the least vascularized - poorly differentiated HCC by CT. At morphometric study of the maximum values of the number and the total cross-sectional area of the blood vessels are installed in high-differentiated HCC tissues, the minimum - in the tissue of low-grade HCC. CT with bolus contrast enhancement allows studying the characteristics of blood supply of HCC varying degrees of differentiation. Determine the true measure of total CT-vascularization of the tumor tissue must be done with consideration of the increase concentration difference coefficient (ICDC).
Keywords
Hepatocellular Carcinoma, Histological Differentiation, Computed Tomography, Contrast Enhancement, Vascularity
To cite this article
Ulyana N. Tumanova, Grigoriy G. Karmazanovsky, Alexander I. Shchyogolev, Computed Tomography Assessment of the Vascularization Degree of Hepatocellular Carcinoma in the Noncirrhotic Liver, American Journal of Clinical and Experimental Medicine. Vol. 3, No. 1, 2015, pp. 24-31. doi: 10.11648/j.ajcem.20150301.13
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